[en] Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis (OA), and osteomodulin (OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] d‐BRU - Dental Biomaterials Research Unit - ULiège [BE]
Disciplines :
Rheumatology
Author, co-author :
Zappia, Jérémie ; Université de Liège - ULiège > Unités de recherche interfacultaires > Centre Interdisciplinaire de Recherche sur le Médicament (CIRM)
Tong, Qiao; School of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, UK
Van der Cruyssen, Renée; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium ; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
Cornelis, Frederique M F; Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium
Lambert, Cécile ; Université de Liège - ULiège > Département des sciences de la motricité > musculoSkeletal Innovative research Lab (mSKIL)
Grisart, Juliane; Artialis SA, Tour GIGA, CHU Sart-Tilman, Liège, Belgium
Kague, Erika ; School of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, UK
Lories, Rik J; Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium ; Division of Rheumatology, University Hospitals Leuven, Leuven, Belgium
Muller, Marc ; Université de Liège - ULiège > Département des sciences de la vie
Elewaut, Dirk; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium ; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
Hammond, Chrissy L; School of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, UK
Sanchez, CHRISTELLE ; Université de Liège - ULiège > Département des sciences de la motricité > musculoSkeletal Innovative research Lab (mSKIL)
Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Pathologie générale et physiopathologie - Techniques particulières de kinésithérapie ; Physical Therapy and Rehabilitation Department, Princess Paola Hospital, Vivalia, Marche-en-Famenne, Belgium
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