Patient assessment using standardized bone mineral density values and a national reference database: implementing uniform thresholds for the reimbursement of osteoporosis treatments in Belgium
[en] Dual-energy X-ray absorptiometry (DXA) devices from the three main manufacturers provide different bone mineral density (BMD) values, due in part to technical differences in the algorithms for bone mineral content (BMC) and area measurements and in part to the use of different manufacturer-derived reference databases. As a result, significant differences exist between Hologic, Lunar and Norland systems in the reported young normal standard deviation scores or T-scores. In a number of European countries, including Belgium, a T-score below -2.5 is one of the key criteria for reimbursement of osteoporosis treatments. This paper addresses the first attempt to implement a nationwide, uniform expression of BMD in patients, in order to harmonize drug reimbursement. To this end, measures were taken to implement a uniform expression of BMD in Belgian patients, by converting each manufacturer's absolute BMD to standardized BMD (sBMD) values and by establishing a single national reference range.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Boonen, S.
Kaufman, J. M.
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Devogelaer, J. P.
Language :
English
Title :
Patient assessment using standardized bone mineral density values and a national reference database: implementing uniform thresholds for the reimbursement of osteoporosis treatments in Belgium
Publication date :
February 2003
Journal title :
Osteoporosis International
ISSN :
0937-941X
eISSN :
1433-2965
Publisher :
Springer-Verlag London Ltd, Godalming, United Kingdom
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Looker AC, Wahner HW, Dunn WI, et al. Proximal femur bone mineral levels of US adults. Osteoporos Int 1995;5:389-409.
Looker AC, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP, et al. Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 1998;8:468-489.
Kanis JA, Glüer C-C for the Committee of Scientific Advisors, International Osteoporosis Foundation. An update on the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int 2000;11:192-202.
Genant HK, Grampp S, Glüer CC, Faulkner KG, Jergas M, Engelke K, et al. Universal standardization for dual X-ray absorptiometry: patient and phantom cross-calibration results. J Bone Miner Res 1994;9:1503-1514.
Hui SL, Gao S, Zhou X-H, Johnston CC, Lu Y, Glüer CC, et al. Universal standardization of bone density measurements: A method with optimal properties for calibration among several instruments. J Bone Miner Res 1997;12:1463-1470.
Hanson J. Standardization of femur BMD. J Bone Miner Res 1997;12:1316-1417.
Lu Y, Fuerst T, Hui S, Genant HK. Standardization of bone mineral density at femoral neck, trochanter and Ward's triangle. Osteoporos Int 2001;12:438-444.
Simmons A, Simpson DE, O'Doherty MJ, Barrington S, Coakley AJ. The effects of standardization and reference values on patient classification for spine and femur dual-energy X-ray absorptiometry. Osteoporos Int 1997;7:200-206.
Löfman O, Larsson L, Toss G. Bone mineral density in diagnosis of osteoporosis. J Clin Densitom 2000;3:177-186.
Simmons A, Simpson DE, O'Doherty MJ, Barrington S, Coakley AJ. The effects of standardization and reference values on patient classification for spine and femur dual-energy X-ray absorptiometry. Osteoporos Int 1997;7:200-206.
Pocock NA, Sambrook PN, Nguyen T, Kelly P, Freund J, Eisman JA. Assessment of spinal and femoral bone density by dual X-ray absorptiometry: comparison of Lunar and Hologic instruments. J Bone Miner Res 1992;7:1081-1084.
Laskey MA, Crisp AJ, Cole TJ, Compston JE. Comparison of the effect of different reference data on Lunar DPX and Hologic QDR-1000 dual-energy X-ray absorptiometers. Br J Radiol 1992;65:1124-1129.
Faulkner KG, Roberts LA, McClung MR. Discrepancies in normative data between Lunar and Hologic DXA systems. Osteoporos Int 1996;6:432-436.
Valimaki MJ, Karkkainen M, Lamberg-Allardt C, et al. Exercise, smoking and calcium intake during adolescence and early adulthood as determinants of peak bone mass. BMJ 1994;309:230-235.
Ahmed AIH, Blake GM, Rymer JM, Fogelman I. Screening for osteopenia and osteoporosis: do the accepted normal ranges lead to overdiagnosis? Osteoporos Int 1997;7:432-438.
Gürlek A, Bayraktar M, Ariyürek M. Inappropriate reference range for peak bone mineral density in dual-energy x-ray absorptiometry: implications for the interpretation of T-scores. Osteoporos Int 2000;11: 809-813.
Cummings SR, Black DM, Thompson DE, et al. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures. Results from the Fracture Intervention Trial (FIT). JAMA 1998;280:2077-2082.
Ettinger B, Black D, Mitlack B, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene. Results from a 3-year randomized clinical trial. JAMA 1999;282:637-645.
Reginster J-Y, Minne HW, Sorensen OH, et al. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Osteoporos Int 2000;11:83-91.
Chesnut CH, Silverman S, Andriano K, et al. A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the Prevent Recurrrence of Osteoporotic Fractures (PROOF) Study. Am J Med 2000;109:267-276.
WHO. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Geneva: WHO, 1994.
Eddy DM, Johnston CC, Cummings SR, Dawson-Hughes B, Lindsay R, Melton LJ, et al. Osteoporosis: review of the evidence for prevention, diagnosis, and treatment and cost-effectiveness analysis. Osteoporos Int 1998;8 (Suppl. 4):S1-88.
Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 1996;312:1254-1259.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.