Article (Scientific journals)
Actinomyces israelii and Fusobacterium nucleatum brain abscess in an immunocompetent patient: case report.
Lamtri Laarif, Mouhsine; Schils, Raphaël; LIFRANGE, Fréderic et al.
2023In Access Microbiology, 5 (6)
Peer reviewed
 

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Keywords :
Actinomyces israelii; Fusobacterium nucleatum; actinomycosis; brain abscesses; periodontitis; Microbiology (medical); Microbiology
Abstract :
[en] [en] INTRODUCTION: Brain abscess is the most common focal infectious neurological injury. Until the nineteenth century this condition was fatal, however the development of neuroimaging for early diagnosis, neurosurgery and antibiotic therapy in the twentieth century has led to new therapeutic strategies decreasing mortality from 50 % in the 1970s to less than 10 % nowadays. In this context we report a case of brain abscess with a dental origin. CASE REPORT: A immunocompetent man without any addiction presented to the emergency department with dysarthria and frontal headache at home. The clinical examination was normal. Further investigations revealed a polymicrobial brain abscess as a consequence of an ear, nose or throat (ENT) infection with locoregional extension with a dental starting point involving Actinomyces israelii and Fusobacterium nucleatum . In spite of a rapid diagnosis and a neurosurgical management associated with an optimal treatment by a dual therapy made of ceftriaxone and metronidazole the patient unfortunately died. CONCLUSION: This case report shows that despite a low incidence and a good prognosis following the diagnosis, brain abscesses can lead to patient's death. Thereby, when the patient's condition and urgency allow, a thorough dental examination of patients with neurological signs following the recommendations would improve the diagnosis made by the clinician. The use of microbiological documentation, the respect of pre-analytical conditions, the interaction between the laboratory and the clinicians are indispensable for an optimal management of these pathologies.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Lamtri Laarif, Mouhsine ;  Department of Clinical Biology, Microbiology, University of Liège Hospital, Liège, Belgium
Schils, Raphaël ;  Centre Hospitalier Universitaire de Liège - CHU > > Service des maladies infectieuses - médecine interne
LIFRANGE, Fréderic  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anatomie et cytologie pathologiques
VALKENBORGH, Christophe ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Pitti, Pauline ;  Centre Hospitalier Universitaire de Liège - CHU > > Pool assistant - biologie clinique
Brouwers, Pauline ;  Department of Clinical Biology, Microbiology, University of Liège Hospital, Liège, Belgium
Bianchi, Elettra ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'anatomie et cytologie pathologiques
Meex, Cécile ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de microbiologie clinique
Hayette, Marie-Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de microbiologie clinique
Language :
English
Title :
Actinomyces israelii and Fusobacterium nucleatum brain abscess in an immunocompetent patient: case report.
Publication date :
2023
Journal title :
Access Microbiology
eISSN :
2516-8290
Publisher :
Microbiology Society, England
Volume :
5
Issue :
6
Peer reviewed :
Peer reviewed
Available on ORBi :
since 24 August 2023

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