[en] Glomerular hyperfiltration (GHF) is a phenomenon that can occur in various clinical conditions affecting the kidneys such as sickle cell disease, diabetes mellitus, autosomal dominant polycystic kidney disease, and solitary functioning kidney. Yet, the pathophysiological mechanisms vary from one disease to another and are not well understood. More so, it has been demonstrated that GHF may occur at the single-nephron in some clinical conditions while in others at the whole-kidney level. In this review, we explore the pathophysiological mechanisms of GHF in relation to various clinical conditions in the pediatric population. In addition, we discuss the role and mechanism of action of important factors such as gender, low birth weight, and race in the pathogenesis of GHF. Finally, in this current review, we further highlight the consequences of GHF in the progression of kidney disease.
Disciplines :
Urologie & néphrologie
Auteur, co-auteur :
Adebayo, Oyindamola C ; Center of Vascular and Molecular Biology, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium
Nkoy, Agathe B ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium ; Division of Nephrology, Department of Pediatrics, Faculty of Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo
van den Heuvel, Lambertus P ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium ; Department of Pediatric Nephrology, Radboud University Medical Centre, 6500 Nijmegen, The Netherlands
Labarque, Veerle ; Center of Vascular and Molecular Biology, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium ; Department of Pediatric Hematology, University Hospitals Leuven, 3000 Leuven, Belgium
Levtchenko, Elena ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium ; Department of Pediatric Nephrology, University Hospitals Leuven, 3000 Leuven, Belgium
Delanaye, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie ; Department of Nephrology-Dialysis-Apheresis, Hôpital Universitaire Carémeau, Nîmes, France
Pottel, Hans ; Université de Liège - ULiège > Département des sciences cliniques ; Department of Public Health and Primary Care, Katholieke Universiteit Leuven, Campus Kulak, 8500 Kortrijk, Belgium. hans.pottel@kuleuven.be
Langue du document :
Anglais
Titre :
Glomerular hyperfiltration: part 2-clinical significance in children.
Date de publication/diffusion :
août 2023
Titre du périodique :
Pediatric Nephrology
ISSN :
0931-041X
eISSN :
1432-198X
Maison d'édition :
Springer Science and Business Media Deutschland GmbH, Allemagne
FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen VLIR-UOS - Flemish Interuniversity Council. Bureau UOS DGD - Direction générale Coopération au Développement et Aide humanitaire
Subventionnement (détails) :
O.C.A. is supported by the fundamental research grant of Fonds Wetenschappelijk Onderzoek-Vlaanderen (FWO) [grant number 11A5621N]. A.B.N is supported by the Global Minds Scholarship of VLIR-UOS and DGD (Belgium partner in development).
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