Glomerular hyperfiltration: part 2-clinical significance in children.

Autosomal dominant polycystic kidney disease (ADPKD); Diabetic kidney disease; Duchenne muscular dystrophy; Glomerular hyperfiltration; Obesity-related glomerulopathy; Pediatric population; Sickle cell disease ; Solitary functioning kidney; Pediatrics, Perinatology and Child Health; Nephrology

Abstract :

[en] Glomerular hyperfiltration (GHF) is a phenomenon that can occur in various clinical conditions affecting the kidneys such as sickle cell disease, diabetes mellitus, autosomal dominant polycystic kidney disease, and solitary functioning kidney. Yet, the pathophysiological mechanisms vary from one disease to another and are not well understood. More so, it has been demonstrated that GHF may occur at the single-nephron in some clinical conditions while in others at the whole-kidney level. In this review, we explore the pathophysiological mechanisms of GHF in relation to various clinical conditions in the pediatric population. In addition, we discuss the role and mechanism of action of important factors such as gender, low birth weight, and race in the pathogenesis of GHF. Finally, in this current review, we further highlight the consequences of GHF in the progression of kidney disease.

Disciplines :

Urology & nephrology

Author, co-author :

Adebayo, Oyindamola C ; Center of Vascular and Molecular Biology, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium

Nkoy, Agathe B ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium ; Division of Nephrology, Department of Pediatrics, Faculty of Medicine, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo

van den Heuvel, Lambertus P ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium ; Department of Pediatric Nephrology, Radboud University Medical Centre, 6500 Nijmegen, The Netherlands

Labarque, Veerle ; Center of Vascular and Molecular Biology, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium ; Department of Pediatric Hematology, University Hospitals Leuven, 3000 Leuven, Belgium

Levtchenko, Elena ; Laboratory of Pediatric Nephrology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Campus Gasthiusberg, 3000 Leuven, Belgium ; Department of Pediatric Nephrology, University Hospitals Leuven, 3000 Leuven, Belgium

Delanaye, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie ; Department of Nephrology-Dialysis-Apheresis, Hôpital Universitaire Carémeau, Nîmes, France

Pottel, Hans ; Université de Liège - ULiège > Département des sciences cliniques ; Department of Public Health and Primary Care, Katholieke Universiteit Leuven, Campus Kulak, 8500 Kortrijk, Belgium. hans.pottel@kuleuven.be

Language :

English

Title :

Glomerular hyperfiltration: part 2-clinical significance in children.

Publication date :

August 2023

Journal title :

Pediatric Nephrology

ISSN :

0931-041X

eISSN :

1432-198X

Publisher :

Springer Science and Business Media Deutschland GmbH, Germany

Volume :

Issue :

Pages :

2529 - 2547

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://link.springer.com/content/pdf/10.1007/s00467-022-05826-5.pdf

Funders :

FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen [BE]
VLIR-UOS - Flemish Interuniversity Council. Bureau UOS [BE]
DGD - Direction générale Coopération au Développement et Aide humanitaire [BE]

Funding text :

O.C.A. is supported by the fundamental research grant of Fonds Wetenschappelijk Onderzoek-Vlaanderen (FWO) [grant number 11A5621N]. A.B.N is supported by the Global Minds Scholarship of VLIR-UOS and DGD (Belgium partner in development).

Available on ORBi :

since 02 August 2023

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