Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma:  Report of an international multicenter cohort study with propensity score matching.

Brustia, Raffaele; Laurent, Alexis; Goumard, Claire; Langella, Serena; Cherqui, Daniel; Kawai, Takayuki; Soubrane, Olivier; Cauchy, Francois; Farges, Olivier; Menahem, Benjamin; Hobeika, Christian; Rhaiem, Rami; Sommacale, Daniele; Okumura, Shinya; Hofmeyr, Stefan; Ferrero, Alessandro; Pruvot, François-René; Regimbeau, Jean-Marc; Fuks, David; Vibert, Eric; Scatton, Olivier; AFC-ICC-2009; AFC-LLR-2018; PRS-2019 Study, group

doi:10.1016/j.surg.2021.08.015

Article (Scientific journals)

Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: Report of an international multicenter cohort study with propensity score matching.

Brustia, Raffaele; Laurent, Alexis; Goumard, Claire et al.

2022 • In Surgery, 171 (5), p. 1290-1302

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/305511

DOI
10.1016/j.surg.2021.08.015

PubMed
34535270

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Keywords :

Bile Duct Neoplasms/pathology; Bile Ducts, Intrahepatic/pathology; Cholangiocarcinoma; Cohort Studies; Hepatectomy; Humans; Laparoscopy/adverse effects; Liver/pathology; Postoperative Complications/etiology; Propensity Score; Retrospective Studies; Treatment Outcome

Abstract :

[en] BACKGROUND: Intrahepatic cholangiocarcinoma is a rare disease with a poor prognosis. In patients where surgical resection is possible, outcome is influenced by perioperative morbidity and lymph node status. Laparoscopic liver resection is associated with improved clinical and oncological outcomes in primary and metastatic liver cancer compared with open liver resection, but evidence on intrahepatic cholangiocarcinoma is still insufficient. The primary aim of this study was to compare overall survival for a large series of patients treated for intrahepatic cholangiocarcinoma by open or laparoscopic approach. Secondary objectives were to compare disease-free survival, predictors of death, and recurrence. METHODS: Patients treated with laparoscopic or open liver resection for intrahepatic cholangiocarcinoma from 2000 to 2018 from 3 large international databases were analyzed retrospectively. Each patient in the laparoscopic resection group (case) was matched with 1 open resection control (1:1 ratio), through a propensity score calculated on clinically relevant preoperative covariates. Overall and disease-free survival were compared between the matched groups. Predictors of mortality and recurrence were analyzed with Cox regression, and the Textbook Outcomes were described. RESULTS: During the study period, 855 patients met the inclusion criteria (open liver resection = 709, 82.9%; laparoscopic liver resection = 146, 17.1%). Two groups of 89 patients each were analyzed after propensity score matching, with no significant difference regarding pre- and postoperative variables. Overall survival at 1, 3, and 5 years was 92%, 75%, and 63% in the laparoscopic liver resection group versus 92%, 58%, and 49% in the open liver resection group (P = .0043). Adjusted Cox regression revealed severe postoperative complications (hazard ratio: 10.5, 95% confidence interval [1.01-109] P = .049) and steatosis (hazard ratio: 13.8, 95% confidence interval [1.23-154] P = .033) as predictors of death, and transfusion (hazard ratio: 19.2, 95% confidence interval [4.04-91.4] P < .001) and severe postoperative complications (hazard ratio: 4.07, 95% confidence interval [1.15-14.4] P = .030) as predictors of recurrence. CONCLUSION: The survival advantage of laparoscopic liver resection over open liver resection for intrahepatic cholangiocarcinoma is equivocal, given historical bias and missing data.

Disciplines :

Surgery
Oncology

Author, co-author :

Brustia, Raffaele; Department of Digestive and Hepato-Pancreatic-Biliary Surgery, DMU CARE,

Laurent, Alexis; Univ Paris Est Creteil, Faculté de Santé, Créteil, France and Department of

Goumard, Claire; Department of Hepatobiliary and Liver Transplantation Surgery, AP-HP, Hôpital

Langella, Serena; Department of General and Oncological Surgery, Ospedale Mauriziano, Torino,

Cherqui, Daniel; Centre Hepato-Biliaire, AP-HP Paul Brousse Hospital, Paris-Saclay University,

Kawai, Takayuki; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto,

Soubrane, Olivier; Department of Hepatobiliary Surgery, APHP, University Hospitals Paris Nord Val de

Cauchy, Francois; Department of Hepatobiliary Surgery, APHP, University Hospitals Paris Nord Val de

Farges, Olivier; Department of Hepatobiliary Surgery, APHP, University Hospitals Paris Nord Val de

Menahem, Benjamin; Department of Digestive Surgery, University Hospital of Caen, France.

More authors (14 more)

Other collaborator :

Abba, Julio

Adam, René

Adham, Mustapha

Allard, Marc-Antoine

Ayav, Ahmet

Azoulay, Daniel

Bachellier, Philippe

Balladur, Pierre

Barbier, Louise

Barbieux, Julien

More authors (98 more)

Language :

English

Title :

Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: Report of an international multicenter cohort study with propensity score matching.

Publication date :

May 2022

Journal title :

Surgery

ISSN :

0039-6060

eISSN :

1532-7361

Publisher :

Eslevier

Volume :

171

Issue :

Pages :

1290-1302

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 30 July 2023

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Bibliography

Razumilava, N., Gores, G.J., Cholangiocarcinoma. Lancet (London, England) 383 (2014), 2168–2179.
Mavros, M.N., Economopoulos, K.P., Alexiou, V.G., Pawlik, T.M., Treatment and prognosis for patients with intrahepatic cholangiocarcinoma. JAMA Surg, 149, 2014, 565.
Shaib, Y., El-Serag, H., The epidemiology of cholangiocarcinoma. Semin Liver Dis 24 (2004), 115–125.
DeOliveira, M.L., Cunningham, S.C., Cameron, J.L., et al. Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution. Ann Surg 245 (2007), 755–762.
Brustia, R., Langella, S., Kawai, T., et al. Preoperative risk score for prediction of long-term outcomes after hepatectomy for intrahepatic cholangiocarcinoma: report of a collaborative, international-based, external validation study. Eur J Surg Oncol 46 (November 2020), 560–571.
Bagante, F., Spolverato, G., Cucchetti, A., et al. Defining when to offer operative treatment for intrahepatic cholangiocarcinoma: a regret-based decision curves analysis. Surgery 160 (2016), 106–117.
Spolverato, G., Kim, Y., Alexandrescu, S., et al. Is hepatic resection for large or multifocal intrahepatic cholangiocarcinoma justified? Results from a multi-institutional collaboration. Ann Surg Oncol 22 (2015), 2218–2225.
Spolverato, G., Yakoob, M.Y., Kim, Y., et al. The impact of surgical margin status on long-term outcome after resection for intrahepatic cholangiocarcinoma. Ann Surg Oncol 22 (2015), 4020–4028.
Bektas, H., Yeyrek, C., Kleine, M., et al. Surgical treatment for intrahepatic cholangiocarcinoma in Europe: a single center experience. J Hepatobiliary Pancreat Sci 22 (2015), 131–137.
Kasai, M., Cipriani, F., Gayet, B., et al. Laparoscopic versus open major hepatectomy: a systematic review and meta-analysis of individual patient data. Surgery 163 (2018), 985–995.
Kim, J.M., Kwon, C.H.D., Yoo, H., et al. Which approach is preferred in left hepatocellular carcinoma? Laparoscopic versus open hepatectomy using propensity score matching. BMC Cancer, 18, 2018.
Komatsu, S., Brustia, R., Goumard, C., Perdigao, F., Soubrane, O., Scatton, O., Laparoscopic versus open major hepatectomy for hepatocellular carcinoma: a matched pair analysis. Surg Endosc Other Interv Tech, 30, 2016.
Beppu, T., Wakabayashi, G., Hasegawa, K., et al. Long-term and perioperative outcomes of laparoscopic versus open liver resection for colorectal liver metastases with propensity score matching: a multi-institutional Japanese study. J Hepatobiliary Pancreat Sci 22 (2015), 711–720.
Nachmany, I., Pencovich, N., Zohar, N., et al. Laparoscopic versus open liver resection for metastatic colorectal cancer. Eur J Surg Oncol 41 (2015), 1615–1620.
Xiangfei, M., Yinzhe, X., Yingwei, P., Shichun, L., Weidong, D., Open versus laparoscopic hepatic resection for hepatocellular carcinoma: a systematic review and meta-analysis. Surg Endosc 33 (2019), 2396–2418.
Syn, N.L., Kabir, T., Koh, Y.X., et al. Survival advantage of laparoscopic versus open resection for colorectal liver metastases: a meta-analysis of individual patient data from randomized trials and propensity-score matched studies. Ann Surg, 22, 2019, 22.
Aghayan, D.L., Kazaryan, A.M., Dagenborg, V.J., et al. Long-term oncologic outcomes after laparoscopic versus open resection for colorectal liver metastases: a randomized trial. Ann Intern Med 174 (2021), 175–182.
El-Gendi, A., El-Shafei, M., El-Gendi, S., Shawky, A., Laparoscopic versus open hepatic resection for solitary hepatocellular carcinoma less than 5 cm in cirrhotic patients: a randomized controlled study. J Laparoendosc Adv Surg Tech A 28 (2018), 302–310.
Wei, F., Wang, G., Ding, J., Dou, C., Yu, T., Zhang, C., Is it time to consider laparoscopic hepatectomy for intrahepatic cholangiocarcinoma? A meta-analysis. J Gastrointest Surg 24 (2020), 2244–2250.
Hobeika, C., Nault, J.C., Barbier, L., et al. Influence of surgical approach and quality of resection on the probability of cure for early-stage HCC occurring in cirrhosis. JHEP Reports, 2, 2020, 100153.
Tsilimigras, D.I., Mehta, R., Merath, K., et al. Hospital variation in textbook outcomes following curative-intent resection of hepatocellular carcinoma: an international multi-institutional analysis. HPB 22 (2020), 1305–1313.
Farges, O., Fuks, D., Le Treut, Y.P., et al. AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma. Cancer 117 (2011), 2170–2177.
von Elm, E., Altman, D.G., Egger, M., et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370 (2007), 1453–1457.
Merath, K., Chen, Q., Bagante, F., et al. A multi-institutional international analysis of textbook outcomes among patients undergoing curative-intent resection of intrahepatic cholangiocarcinoma. JAMA Surg, 154, 2019.
Kawaguchi, Y., Hasegawa, K., Tzeng, C.W.D., et al. Performance of a modified three-level classification in stratifying open liver resection procedures in terms of complexity and postoperative morbidity. Br J Surg 107 (2020), 258–267.
Kawaguchi, Y., Fuks, D., Kokudo, N., Gayet, B., Difficulty of laparoscopic liver resection. Ann Surg 267 (2018), 13–17.
Bridgewater, J., Galle, P.R., Khan, S.A., et al. Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J Hepatol 60 (2014), 1268–1289.
Amin, M., Edge, S., Greene, F., et al. (eds.) AJCC Cancer Staging Manual, 8th Edition, 2017, Springer International Publishing: American Joint Commission on Cancer.
Zhang, X.F., Chakedis, J., Bagante, F., et al. Trends in use of lymphadenectomy in surgery with curative intent for intrahepatic cholangiocarcinoma. Br J Surg 105 (2018), 857–866.
Dindo, D., Demartines, N., Clavien, P.A., Classification of surgical complications. Ann Surg 240 (2004), 205–213.
Kang, S.H., Choi, Y.R., Lee, W., et al. Laparoscopic liver resection versus open liver resection for intrahepatic cholangiocarcinoma: 3-year outcomes of a cohort study with propensity score matching. Surg Oncol 33 (2020), 63–69.
Chen, K., Pan, Y., Zhang, B., Liu, X.L., Maher, H., Zheng, X.Y., Laparoscopic versus open surgery for hepatocellular carcinoma: a meta-analysis of high-quality case-matched studies. Can J Gastroenterol Hepatol, 2018, 2018, 1746895.
Yamamoto, M., Kobayashi, T., Oshita, A., et al. Laparoscopic versus open limited liver resection for hepatocellular carcinoma with liver cirrhosis: a propensity score matching study with the Hiroshima Surgical study group of Clinical Oncology (HiSCO). Surg Endosc 34 (2020), 5055–5061.
Wang, Z.Y., Chen, Q.L., Sun, L.L., et al. Laparoscopic versus open major liver resection for hepatocellular carcinoma: systematic review and meta-analysis of comparative cohort studies. BMC Cancer, 19, 2019, 1047.
Brustia, R., Fleres, F., Tamby, E., et al. Postoperative collections after liver surgery: risk factors and impact on long-term outcomes. J Visc Surg 157 (2020), 199–209.
Margonis, G.A., Sasaki, K., Andreatos, N., et al. Prognostic impact of complications after resection of early stage hepatocellular carcinoma. J Surg Oncol 115 (2017), 791–804.
Sasaki, K., Margonis, G.A., Andreatos, N., et al. Preoperative risk score and prediction of long-term outcomes after hepatectomy for intrahepatic cholangiocarcinoma. J Am Coll Surg 226 (2018), 393–403.
Martin, S.P., Drake, J., Wach, M.M., et al. Laparoscopic approach to intrahepatic cholangiocarcinoma is associated with an exacerbation of inadequate nodal staging. Ann Surg Oncol 26 (2019), 1851–1857.
Yoh, T., Cauchy, F., Le Roy, B., et al. Prognostic value of lymphadenectomy for long-term outcomes in node-negative intrahepatic cholangiocarcinoma: a multicenter study. Surgery 166 (2019), 975–982.
Feng, L.F., Yan, P.J., Chu, X.J., et al. A scientometric study of the top 100 most-cited publications based on Web of Science of robotic surgery versus laparoscopic surgery. Asian J Surg 44 (2021), 440–451.
Byun, Y., Choi, Y.J., Kang, J.S., et al. Early outcomes of robotic extended cholecystectomy for the treatment of gallbladder cancer. J Hepatobiliary Pancreat Sci 27 (2020), 324–330.
Byun, Y., Choi, Y.J., Kang, J.S., et al. Robotic extended cholecystectomy in gallbladder cancer. Surg Endosc 34 (2020), 3256–3261.
Napoli, N., Kauffmann, E.F., Menonna, F., Iacopi, S., Cacace, C., Boggi, U., Robot-assisted radical antegrade modular pancreatosplenectomy including resection and reconstruction of the spleno-mesenteric junction. J Vis Exp, 3, 2020.
Hameed, I., Aggarwal, P., Weiser, M.R., Robotic extended right hemicolectomy with complete mesocolic excision and D3 lymph node dissection. Ann Surg Oncol 26 (2019), 3990–3991.
Chong, E.H., Choi, S.H., Hybrid laparoscopic and robotic hepatopancreaticoduodenectomy for cholangiocarcinoma. J Gastrointest Surg 23 (2019), 1947–1948.
Amini, N., Margonis, G.A., Kim, Y., Wilson, A., Gani, F., Pawlik, T.M., Complication timing impacts 30-d mortality after hepatectomy. J Surg Res 203 (2016), 495–506.
Matsuda, A., Matsumoto, S., Seya, T., et al. Does postoperative complication have a negative impact on long-term outcomes following hepatic resection for colorectal liver metastasis?: a meta-analysis. Ann Surg Oncol 20 (2013), 2485–2492.
Melloul, E., Hübner, M., Scott, M., et al. Guidelines for perioperative care for liver surgery: Enhanced Recovery After Surgery (ERAS) Society recommendations. World J Surg 40 (2016), 2425–2440.
Ljungqvist, O., Scott, M., Fearon, K.C., Enhanced recovery after surgery. JAMA Surg, 152, 2017, 292.
Chalmers, I., Glasziou, P., Avoidable waste in the production and reporting of research evidence. Lancet 374 (2009), 86–89.
Yordanov, Y., Dechartres, A., Atal, I., et al. Avoidable waste of research related to outcome planning and reporting in clinical trials. BMC Med, 16, 2018, 87.
Mansukhani, N.A., Patti, M.G., Kibbe, M.R., Rebranding “the lab years” as “professional development” in order to redefine the modern surgeon scientist. Ann Surg 266 (2017), 937–938.