Article (Scientific journals)
Cytomegalovirus infection management in solid organ transplant recipients across European centers in the time of molecular diagnostics: An ESGICH survey.
Navarro, David; San-Juan, Rafael; Manuel, Oriol et al.
2017In Transplant Infectious Disease, 19 (6)
Peer reviewed
 

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Keywords :
Antiviral Agents; DNA, Viral; Antibiotic Prophylaxis/methods/standards/statistics & numerical data; Antiviral Agents/standards/therapeutic use; Cross-Sectional Studies; Cytomegalovirus/genetics/isolation & purification; Cytomegalovirus Infections/diagnosis/pathology/therapy/virology; DNA, Viral/isolation & purification; Europe; Guideline Adherence/statistics & numerical data; Health Care Surveys/statistics & numerical data; Humans; Immunocompromised Host; Immunosuppression Therapy/adverse effects/methods; Organ Transplantation/adverse effects; Postoperative Complications/diagnosis/pathology/therapy/virology; Practice Guidelines as Topic; Practice Patterns, Physicians'/standards/statistics & numerical data; Real-Time Polymerase Chain Reaction/statistics & numerical data; Transplant Recipients/statistics & numerical data; Transplants/pathology/virology; Viral Load/methods; cytomegalovirus; solid organ transplantation; survey
Abstract :
[en] BACKGROUND: Scant information is available about how transplant centers are managing their use of quantitative molecular testing (QNAT) assays for active cytomegalovirus (CMV) infection monitoring in solid organ transplant (SOT) recipients. The current study was aimed at gathering information on current practices in the management of CMV infection across European centers in the era of molecular testing assays. METHODS: A questionnaire-based cross-sectional survey study was conducted by the European Study Group of Infections in Immunocompromised Hosts (ESGICH) of the Society of Clinical Microbiology and Infectious Diseases (ESCMID). The invitation and a weekly reminder with a personal link to an Internet service provider (https://es.surveymonkey.com/) was sent to transplant physicians, transplant infectious diseases specialists, and clinical virologists working at 340 European transplant centers. RESULTS: Of the 1181 specialists surveyed, a total of 173 responded (14.8%): 73 transplant physicians, 57 transplant infectious diseases specialists, and 43 virologists from 173 institutions located at 23 different countries. The majority of centers used QNAT assays for active CMV infection monitoring. Most centers preferred commercially available real-time polymerase chain reaction (RT-PCR) assays over laboratory-developed procedures for quantifying CMV DNA load in whole blood or plasma. Use of a wide variety of DNA extraction platforms and RT-PCR assays was reported. All programs used antiviral prophylaxis, preemptive therapy, or both, according to current guidelines. However, the centers used different criteria for starting preemptive antiviral treatment, for monitoring systemic CMV DNA load, and for requesting genotypic assays to detect emerging CMV-resistant variants. CONCLUSIONS: Significant variation in CMV infection management in SOT recipients still remains across European centers in the era of molecular testing. International multicenter studies are required to achieve commutability of CMV testing and antiviral management procedures.
Disciplines :
Surgery
Immunology & infectious disease
Author, co-author :
Navarro, David ;  Microbiology Service, Hospital Clínico Universitario, Institute for Research  ; Department of Microbiology, School of Medicine, University of Valencia, Valencia
San-Juan, Rafael;  Unit of Infectious Diseases, Instituto de Investigación Hospital 12 de Octubre
Manuel, Oriol;  Transplantation Center and Service of Infectious Diseases, University Hospital of
Giménez, Estela;  Microbiology Service, Hospital Clínico Universitario, Institute for Research
Fernández-Ruiz, Mario ;  Unit of Infectious Diseases, Instituto de Investigación Hospital 12 de Octubre
Hirsch, Hans H;  Transplantation & Clinical Virology, Department Biomedicine, University of Basel,  ; Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel,
Grossi, Paolo Antonio;  National Centre for Transplantation, Department of Medicine and Surgery,
Aguado, José María;  Unit of Infectious Diseases, Instituto de Investigación Hospital 12 de Octubre
ESGICH CMV Survey Study Group, on behalf of the European Study Group of
Other collaborator :
Abram, Maja
Abramowicz, Daniel
Álamo, José-María
Alp, Sehnaz
Andres-Belmonte, Amado
Anne-Catherine, Pouleur
Antonelli, Barbara
Arnol, Miha
Arslan, Ayse Hande
Asderakis, Argiris
Baldanti, Fausto
Beneyto-Castello, Isabel
Benoit, Kabamba Mukadi
Blanes, Marino
Boggian, Katia
Bonofiglio, Renzo
Bubonja-Sonje, Marina
Caillard, Sophie
Calvo, Jorge
Capone, Alessandro
Cappelli, Gianni
Carmellini, Mario
Casafont, Fernando
Beatriz Castro-Hernandez, M
Catalan, Pilar
Celine, Bressollette-Bodin
Christoph, Berger
Cordero, Elisa
Costa, Cristina
Coussement, Julien
Cuervas-Mons, Valentin
David, Miruna
de la Torre Cisneros, Julián
Delgado, Juan F
Dello Strologo, Luca
Detry, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de chirurgie abdo, sénologique, endocrine et de transplantation
Dexter, Laura
Dieter, Hoffmann
Meis-Hübinger, Anna
Epailly, Eric
Ericzon, Bo-Goran
Eriksson, Britt-Marie
Fehervari, Imre
FitzGerald, Susan
Folgueira, Lola
Fortun, Jesus
Franceschini, Erica
Francois, Proot
Friman, Vanda
Frimmel, Silvius
Garzoni, Christian
Gimeno, Adelina
Gkrania-Klotsas, Effrossyni
Greer, Mark
Griffiths, Paul
Grinyó, Josep M
Guaraldi, Giovanni
Gupte, Girish
Hammad, Abdul
Hart, Ian
Helanterä, Ilkka
Hellemans, Rachel
Hernández, Domingo
Herrero, Jose Ignacio
Hiesse, Christian
Hoppe-Lotichius, Maria
Hryniewiecka, Ewa
Jaksch, Peter
Jan, Lerut
Paul, Brion Jean
Jensen-Fangel, Soren
Joerg, Steinmann
Johan, Vanhaecke
Johannessen, Ingolfur
Johansson, Inger
Kamar, Nassim
Kizilates, Filiz
Knoop, Christiane
Laurent, Belec
Lauro, Augusto
Lautenschlager, Irmeli
Lauzurica, Ricardo
Liebert, U G
Dela Monica, PaolaLilla
Llado, Laura
Lopez-Andujar, Rafael
Luciani, Filippo
Maccherini, Massimo
Maertens, Johan
Maggiore, Umberto
Manrique, Alejandro
Marcos, Maria Angeles
Marekovic, Ivana
Marques, Nuno
Martin, Nitschke
Martine, Neau
Martinez-Sapiña, Ana
Mateos Lindemann, M Luisa
Mazuecos, Auxiliadora
Merino, Esperanza
Moreso, Francesc
Mueller, Nicolas
Muir, David
Mularoni, Alessandra
Muñoz, Patricia
Muñoz-Sanz, Agustín
Nadalin, Silvio
Laura Ambra, Nicolini
Nosotti, Mario
Gorman, Joanne O
Osman, Husam
Padalko, Elizaveta
Palop-Borrás, Begoña
Javirparmer
Pascual, Sonia
Pena López, María José
Pérez-Sáenz, José Luis
Pistello, Mauro
Francisca Portero, M
Puchhammer, Elisabeth
Racca, Sara
Rahamat-Langendoen, Janette
Ramos, Antonio
Boluda, Esther Ramos
Raza, Mohammad
Regalia, Enrico
Reina, Gabriel
Reischig, Tomas
Reuter, Stefan
Rodríguez-Ferrero, M Luisa
Roilides, Emmanuel
Rolla, Serena
Rollag, Halvor
Rostaing, Lionel
Russo, Francesco Paolo
Sabé, Núria
Saliba, Faouzi
Sánchez-Fructuoso, Ana
Scotton, Giorgio
Serra, Nuria
Sgarabotto, Dino
Stojanovic, Jelena
Tasbakan, Meltem
Telenti, Mauricio
Terhes, Gabriella
Thorban, Stefan
Tihic, Nijaz
Travi, Giovanna
Tulissi, Patrizia
Van Delden, Christian
Van Leer, Coretta
Van Loo, Inge
Varona-Bosque, María Aránzazu
Veroux, Massimiliano
Vila-Santandreu, Ana
Waugh, Sheila
Zibar, Lada
Zschiedr, Stefan
More authors (148 more) Less
Language :
English
Title :
Cytomegalovirus infection management in solid organ transplant recipients across European centers in the time of molecular diagnostics: An ESGICH survey.
Publication date :
December 2017
Journal title :
Transplant Infectious Disease
ISSN :
1398-2273
eISSN :
1399-3062
Volume :
19
Issue :
6
Peer reviewed :
Peer reviewed
Funding number :
G0701652/MRC_/Medical Research Council/United Kingdom
Commentary :
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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