Humans; Aged; Emotions; Amygdala/diagnostic imaging; Magnetic Resonance Imaging; Brain Mapping; Brain/diagnostic imaging; Neuroscience (miscellaneous); Aging; Geriatrics and Gerontology
Abstract :
[en] Basic emotional functions seem well preserved in older adults. However, their reactivity to and recovery from socially negative events remain poorly characterized. To address this, we designed a 'task-rest' paradigm in which 182 participants from two independent experiments underwent functional magnetic resonance imaging while exposed to socio-emotional videos. Experiment 1 (N = 55) validated the task in young and older participants and unveiled age-dependent effects on brain activity and connectivity that predominated in resting periods after (rather than during) negative social scenes. Crucially, emotional elicitation potentiated subsequent resting-state connectivity between default mode network and amygdala exclusively in older adults. Experiment 2 replicated these results in a large older adult cohort (N = 127) and additionally showed that emotion-driven changes in posterior default mode network-amygdala connectivity were associated with anxiety, rumination and negative thoughts. These findings uncover the neural dynamics of empathy-related functions in older adults and help understand its relationship to poor social stress recovery.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège [BE]
Disciplines :
Neurosciences & behavior
Author, co-author :
Baez-Lugo, Sebastian ; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland. sebastian.baezlugo@unige.ch ; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland. sebastian.baezlugo@unige.ch
Deza-Araujo, Yacila I ; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland ; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland
Maradan, Christel; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie ; Université de Liège - ULiège > GIGA > GIGA CRC In vivo Imaging - Aging & Memory
Lutz, Antoine; EDUWELL team, Lyon Neuroscience Research Centre (INSERM U1028, CNRS UMR5292, Lyon 1 University), Lyon, France
Marchant, Natalie L ; Division of Psychiatry, University College London, London, UK
Chételat, Gaël ; Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, GIP Cyceron, Caen, France
Vuilleumier, Patrik ; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland. patrik.vuilleumier@unige.ch ; Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland. patrik.vuilleumier@unige.ch
Klimecki, Olga ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie ; Swiss Center for Affective Sciences, University of Geneva, Geneva, Switzerland. olga.klimecki@unige.ch ; Deutsches Zentrum für Neurodegenerative Erkrankungen, Dresden, Germany. olga.klimecki@unige.ch
Medit-Ageing Research Group
Language :
English
Title :
Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults.
H2020 - 667696 - MEDIT-AGEING - Investigating the impact of meditation training on mental health and wellbeing in the ageing population
Funders :
UE - Union Européenne [BE] Federal Department of Economic Affairs Education and Research [CH]
Funding text :
Experiment 1 was financed by funding from the Secrétariat d'État à la formation, à la recherche et à l’innovation (SEFRI) to P.V. and O.K., under contract no. 15.0336 in the context of the European project ‘Medit-Ageing’. The Age-Well randomized clinical trial (including experiment 2) is part of the Medit-Ageing project and is funded through the European Union’s Horizon 2020 Research and Innovation Program (grant agreement no. 667696), Institut National de la Santé et de la Recherche Médicale, Région Normandie, and Fondation d’Entreprise MMA des Entrepreneurs du Futur to G.C., the project principal investigator (PI), and O.K., N.L.M., G.C. and A.L, work package leaders (co-PIs). Institut National de la Santé et de la Recherche Médicale (Inserm) is the sponsor. The funders and sponsor had no role in study design, data collection, and analysis, decision to publish or preparation of the manuscript. The authors are grateful to the Cyceron staff members for their help with neuroimaging data acquisition; as well as to the EUCLID team, the sponsor (H. Espérou, Pôle de recherche Clinique Inserm) and to all the participants in this study for their contribution. We acknowledge and thank the Medit-Ageing Research Group members for their contribution. We thank C. Bordas, S. de Cataldo and J. Sachs for their help on the mental thoughts analyses and their dedication during data acquisition. We also thank B. Bonnet and F. Grouiller as the principal staff members of the Brain and Behavior Laboratory in Geneva.Experiment 1 was financed by funding from the Secrétariat d'État à la formation, à la recherche et à l’innovation (SEFRI) to P.V. and O.K., under contract no. 15.0336 in the context of the European project ‘Medit-Ageing’. The Age-Well randomized clinical trial (including experiment 2) is part of the Medit-Ageing project and is funded through the European Union’s Horizon 2020 Research and Innovation Program (grant agreement no. 667696), Institut National de la Santé et de la Recherche Médicale, Région Normandie, and Fondation d’Entreprise MMA des Entrepreneurs du Futur to G.C., the project principal investigator (PI), and O.K., N.L.M., G.C. and A.L, work package leaders (co-PIs). Institut National de la Santé et de la Recherche Médicale (Inserm) is the sponsor. The funders and sponsor had no role in study design, data collection, and analysis, decision to publish or preparation of the manuscript. The authors are grateful to the Cyceron staff members for their help with neuroimaging data acquisition; as well as to the EUCLID team, the sponsor (H. Espérou, Pôle de recherche Clinique Inserm) and to all the participants in this study for their contribution. We acknowledge and thank the Medit-Ageing Research Group members for their contribution. We thank C. Bordas, S. de Cataldo and J. Sachs for their help on the mental thoughts analyses and their dedication during data acquisition. We also thank B. Bonnet and F. Grouiller as the principal staff members of the Brain and Behavior Laboratory in Geneva.; Federal Department of Economic Affairs, Education and Research, Switzerland | Staatssekretariat für Bildung, Forschung und Innovation
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