[en] BACKGROUND: Fatigue is commonly reported by patients with inflammatory bowel disease (IBD), but the determinants of IBD-related fatigue have yet to be determined. AIMS: To identify the factors associated with fatigue in a large population of patients with IBD. PATIENTS AND METHODS: Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centers. Fatigue and severe fatigue were defined as energy subscores >5 and >7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios (ORs) are provided with 95% confidence intervals). RESULTS: The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease (64.9% vs. 44.7% and 47.4% vs. 28.6%, respectively; p<0.001 for both comparisons). In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age >40 years (OR=0.71 [0.54-0.93]), female sex (OR=1.48 [1.13-1.93]), IBD-related sick leave (OR=1.61 (1.19-2.16]), and joint pain (OR=1.60 [1.17-2.18]), abdominal pain (OR=1.78 [1.29-2.45]), regulating defecation (OR=1.67 [1.20-2.32]), education and work (OR=1.96 [1.40-2.75]), body image (OR=1.38 [1.02-1.86]), sleep (OR=3.60 [2.66-4.88]) and emotions (OR=3.60 [2.66-4.88]) subscores > 5. CONCLUSION: Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep, and emotional disturbances, thus supporting a holistic approach to IBD patient care.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Amiot, Aurelien ; Department of Gastroenterology, Hopitaux Universitaires Bicêtre, AP-HP
Chaibi, Sayma; Department of Gastroenterology, Henri Mondor Hospital, Paris Est-Créteil Val de
Bouhnik, Yoram; Department of Gastroenterology, IBD and Nutrition Support, Beaujon Hospital,
Serrero, Melanie; Hôpital Nord, Centre d'investigation Clinique Marseille Nord, Université
Filippi, Jerome; Department of Gastroenterology and Clinical Nutrition, CHU of Nice, University
Roblin, Xavier; Department of Gastroenterology, Saint-Etienne University Hospital, Saint-Etienne,
Bourrier, Anne; Department of Gastroenterology, AP-HP, Hôpital Saint-Antoine, , UPMC Université
Bouguen, Guillaume; Department of Gastroenterology, CHU Rennes and University of Rennes, NUMECAN
Franchimont, Denis ; Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie ; Department of Gastroenterology, Hôpital Erasme, Laboratoire de Gastroenterologie
Savoye, Guillaume; Department of Gastroenterology, Rouen University Hospital, Rouen, France.
Buisson, Anthony ; Department of Hepato-Gastroenterology, University Hospital Estaing of Clermont
Louis, Edouard ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Nancey, Stephane; Department of Gastroenterology, Lyon-Sud Hospital, Hospices Civils de Lyon and
Abitbol, Vered; Department of Gastroenterology, Cochin University Hospital, Paris, France.
Reimund, Jean-Marie; Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, Hôpitaux
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