Article (Scientific journals)
Prevalence and determinants of fatigue in patients with IBD: a cross-sectional survey from the GETAID.
Amiot, Aurelien; Chaibi, Sayma; Bouhnik, Yoram et al.
2023In Journal of Crohn's and Colitis
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Keywords :
Crohn’s disease; disability; fatigue; inflammatory bowel disease; ulcerative colitis
Abstract :
[en] BACKGROUND: Fatigue is commonly reported by patients with inflammatory bowel disease (IBD), but the determinants of IBD-related fatigue have yet to be determined. AIMS: To identify the factors associated with fatigue in a large population of patients with IBD. PATIENTS AND METHODS: Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centers. Fatigue and severe fatigue were defined as energy subscores >5 and >7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios (ORs) are provided with 95% confidence intervals). RESULTS: The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease (64.9% vs. 44.7% and 47.4% vs. 28.6%, respectively; p<0.001 for both comparisons). In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age >40 years (OR=0.71 [0.54-0.93]), female sex (OR=1.48 [1.13-1.93]), IBD-related sick leave (OR=1.61 (1.19-2.16]), and joint pain (OR=1.60 [1.17-2.18]), abdominal pain (OR=1.78 [1.29-2.45]), regulating defecation (OR=1.67 [1.20-2.32]), education and work (OR=1.96 [1.40-2.75]), body image (OR=1.38 [1.02-1.86]), sleep (OR=3.60 [2.66-4.88]) and emotions (OR=3.60 [2.66-4.88]) subscores > 5. CONCLUSION: Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep, and emotional disturbances, thus supporting a holistic approach to IBD patient care.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Amiot, Aurelien ;  Department of Gastroenterology, Hopitaux Universitaires Bicêtre, AP-HP
Chaibi, Sayma;  Department of Gastroenterology, Henri Mondor Hospital, Paris Est-Créteil Val de
Bouhnik, Yoram;  Department of Gastroenterology, IBD and Nutrition Support, Beaujon Hospital,
Serrero, Melanie;  Hôpital Nord, Centre d'investigation Clinique Marseille Nord, Université
Filippi, Jerome;  Department of Gastroenterology and Clinical Nutrition, CHU of Nice, University
Roblin, Xavier;  Department of Gastroenterology, Saint-Etienne University Hospital, Saint-Etienne,
Bourrier, Anne;  Department of Gastroenterology, AP-HP, Hôpital Saint-Antoine, , UPMC Université
Bouguen, Guillaume;  Department of Gastroenterology, CHU Rennes and University of Rennes, NUMECAN
Franchimont, Denis ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie ; Department of Gastroenterology, Hôpital Erasme, Laboratoire de Gastroenterologie
Savoye, Guillaume;  Department of Gastroenterology, Rouen University Hospital, Rouen, France.
Buisson, Anthony ;  Department of Hepato-Gastroenterology, University Hospital Estaing of Clermont
Louis, Edouard  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Nancey, Stephane;  Department of Gastroenterology, Lyon-Sud Hospital, Hospices Civils de Lyon and
Abitbol, Vered;  Department of Gastroenterology, Cochin University Hospital, Paris, France.
Reimund, Jean-Marie;  Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, Hôpitaux
Dewit, Olivier ;  Université de Liège - ULiège > Centres généraux > IFRES - FORMASUP ; Cliniques Universitaires Saint-Luc, UCL, Brussels, Belgium.
Vuitton, Lucine;  Department of Gastroenterology, Besancon University Hospital, Besancon, France.
Mathieu, Nicolas;  Department of Hepato-Gastroenterology and Digestive Oncology, Grenoble Alpes
Peyrin-Biroulet, Laurent;  Department of Gastroenterology, Nancy University Hospital, Inserm U1256 NGERE,
Gilletta, Cyrielle;  Department of Gastroenterology, Toulouse University Hospital, Toulouse, France.
Allez, Matthieu;  Department of Gastroenterology, Saint-Louis University Hospital, Paris, France.
Viennot, Stephanie;  Department of Gastroenterology, Caen University Hospital, Caen, France.
Le Berre, Catherine ;  Hépato-Gastro-Entérologie et Assistance Nutritionnelle, Inserm CIC 1413, Inserm
Dib, Nina;  Department of HepatoGastroenterology, Angers University Hospital, Angers, France.
Brixi, Hedia;  Department of GastroEnterology, Reims University Hospital, Rheims, France.
Painchart, Claire;  Department of Gastroenterology, Valenciennes General Hospital, Valenciennes,
Plastaras, Laurianne;  Department of Hepato-Gastroenterology, Hospital Pasteur, Colmar, France.
Altwegg, Romain;  Department of Gastroenterology, Hôpital Saint-Eloi, University Hospital of 28
Fumery, Mathurin;  Service d'Hépato-gastroentérologie, Centre Hospitalier Universitaire
Caillo, Ludovic;  Department of Gastroenterology, Nimes University Hospital, Nimes, France.
Laharie, David;  CHU de Bordeaux, Hôpital Haut-Lévêque, Service d'Hépato-gastroentérologie et
Nachury, Maria;  Univ. Lille, INSERM, CHU Lille, U1286 - INFINITE - Institute for Translational
GETAID-patient experience study, group
More authors (23 more) Less
Language :
English
Title :
Prevalence and determinants of fatigue in patients with IBD: a cross-sectional survey from the GETAID.
Publication date :
29 March 2023
Journal title :
Journal of Crohn's and Colitis
ISSN :
1873-9946
eISSN :
1876-4479
Publisher :
Oxford University Press, Oxford, Gb
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
AbbVie [BE]
Commentary :
© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Available on ORBi :
since 28 June 2023

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