[en] BACKGROUND: Fatigue is commonly reported by patients with inflammatory bowel disease (IBD), but the determinants of IBD-related fatigue have yet to be determined. AIMS: To identify the factors associated with fatigue in a large population of patients with IBD. PATIENTS AND METHODS: Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centers. Fatigue and severe fatigue were defined as energy subscores >5 and >7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios (ORs) are provided with 95% confidence intervals). RESULTS: The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease (64.9% vs. 44.7% and 47.4% vs. 28.6%, respectively; p<0.001 for both comparisons). In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age >40 years (OR=0.71 [0.54-0.93]), female sex (OR=1.48 [1.13-1.93]), IBD-related sick leave (OR=1.61 (1.19-2.16]), and joint pain (OR=1.60 [1.17-2.18]), abdominal pain (OR=1.78 [1.29-2.45]), regulating defecation (OR=1.67 [1.20-2.32]), education and work (OR=1.96 [1.40-2.75]), body image (OR=1.38 [1.02-1.86]), sleep (OR=3.60 [2.66-4.88]) and emotions (OR=3.60 [2.66-4.88]) subscores > 5. CONCLUSION: Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep, and emotional disturbances, thus supporting a holistic approach to IBD patient care.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Amiot, Aurelien ; Department of Gastroenterology, Hopitaux Universitaires Bicêtre, AP-HP
Chaibi, Sayma; Department of Gastroenterology, Henri Mondor Hospital, Paris Est-Créteil Val de
Bouhnik, Yoram; Department of Gastroenterology, IBD and Nutrition Support, Beaujon Hospital,
Serrero, Melanie; Hôpital Nord, Centre d'investigation Clinique Marseille Nord, Université
Filippi, Jerome; Department of Gastroenterology and Clinical Nutrition, CHU of Nice, University
Roblin, Xavier; Department of Gastroenterology, Saint-Etienne University Hospital, Saint-Etienne,
Bourrier, Anne; Department of Gastroenterology, AP-HP, Hôpital Saint-Antoine, , UPMC Université
Bouguen, Guillaume; Department of Gastroenterology, CHU Rennes and University of Rennes, NUMECAN
Franchimont, Denis ; Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie ; Department of Gastroenterology, Hôpital Erasme, Laboratoire de Gastroenterologie
Savoye, Guillaume; Department of Gastroenterology, Rouen University Hospital, Rouen, France.
Buisson, Anthony ; Department of Hepato-Gastroenterology, University Hospital Estaing of Clermont
Louis, Edouard ; Centre Hospitalier Universitaire de Liège - CHU > > Service de gastroentérologie, hépatologie, onco. digestive
Nancey, Stephane; Department of Gastroenterology, Lyon-Sud Hospital, Hospices Civils de Lyon and
Abitbol, Vered; Department of Gastroenterology, Cochin University Hospital, Paris, France.
Reimund, Jean-Marie; Service d'Hépato-Gastroentérologie et d'Assistance Nutritive, Hôpitaux
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Le Berre C, Flamant M, Bouguen G, et al. VALIDation of the IBD-disk instrument for assessing disability in inflammatory bowel diseases in a french cohort: the validate study. J Crohns Colitis 2020;14:1512–23. doi:10.1093/ecco-jcc/jjaa100.
Tadbiri S, Nachury M, Bouhnik Y, et al. The IBD-disk is a reliable tool to assess the daily-life burden of patients with inflammatory bowel disease. J Crohns Colitis 2020;44:766–73. doi:10.1093/ ecco-jcc/jjaa244.
Gower-Rousseau C, Sarter H, Savoye G, et al; International Pro-gramme to Develop New Indexes for Crohn's Disease (IPNIC) group. Validation of the Inflammatory Bowel Disease Disability Index in a population-based cohort. Gut 2017;66:588–96. doi:10.1136/gutjnl-2015-310151.
Peyrin-Biroulet L, Cieza A, Sandborn WJ, et al. Disability in inflammatory bowel diseases: developing ICF Core Sets for patients with inflammatory bowel diseases based on the International Classification of Functioning, Disability, and Health. Inflamm Bowel Dis 2010;16:15–22. doi:10.1002/ibd.21010.
WHO. International Classification of Functioning, Disability and Health (ICF). Geneva: WHO; 2001.
Farrell D, McCarthy G, Savage E. Self-reported symptom burden in individuals with inflammatory bowel disease. J Crohns Colitis 2016;10:315–22. doi:10.1093/ecco-jcc/jjv218.
D’Silva A, Fox DE, Nasser Y, et al. Prevalence and risk factors for fatigue in adults with inflammatory bowel disease: a systematic review with meta-analysis. Clin Gastroenterol Hepatol 2022;20:995–1009.e7. doi:10.1016/j.cgh.2021.06.034.
McGing JJ, Radford SJ, Francis ST, Serres S, Greenhaff PL, Moran GW. Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies. Aliment Pharmacol Ther 2021;54:368–87. doi:10.1111/apt.16465.
Christensen KR, Ainsworth MA, Steenholdt C, et al. Fatigue is a systemic extraintestinal disease manifestation largely independent of disease activity, chronicity, and nutritional deficiencies in inflammatory bowel disease on biologics. Scand J Gastroenterol 2022;1:7. doi:10.1080/00365521.2022.2060049.
Tannoury J, Nachury M, Martins C, et al. Determinants of IBD-related disability: a cross-sectional survey from the GETAID. Aliment Pharmacol Ther 2021. doi:10.1111/apt.16353.
Ghosh S, Louis E, Beaugerie L, et al. Development of the IBD disk: a visual self-administered tool for assessing disability in inflammatory bowel diseases. Inflamm Bowel Dis 2017;23:333–40. doi:10.1097/MIB.0000000000001033.
Barsevick AM, Cleeland CS, Manning DC, et al; ASCPRO (Assessing Symptoms of Cancer Using Patient-Reported Outcomes). ASCPRO recommendations for the assessment of fatigue as an outcome in clinical trials. J Pain Symptom Manage 2010;39:1086–99. doi:10.1016/j.jpainsymman.2010.02.006.
Freeman D, Sheaves B, Waite F, Harvey AG, Harrison PJ. Sleep disturbance and psychiatric disorders. Lancet Psychiatry 2020;7:628–37. doi:10.1016/S2215-0366(20)30136-X.
Ballesio A, Zagaria A, Baccini F, Micheli F, Di Nardo G, Lombardo C. A meta-analysis on sleep quality in inflammatory bowel disease. Sleep Med Rev 2021;60:101518. doi:10.1016/j. smrv.2021.101518.
Hao G, Zhu B, Li Y, Wang P, Li L, Hou L. Sleep quality and disease activity in patients with inflammatory bowel disease: a systematic review and meta-analysis. Sleep Med 2020;75:301–8. doi:10.1016/j.sleep.2020.08.032.
Barberio B, Zamani M, Black CJ, Savarino EV, Ford AC. Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2021;6:359–70. doi:10.1016/ S2468-1253(21)00014-5.
Umar N, King D, Chandan JS, et al. The association between inflammatory bowel disease and mental ill health: a retrospective cohort study using data from UK primary care. Aliment Pharmacol Ther 2022;56:814–22. doi:10.1111/apt.17110.
Borren NZ, van der Woude CJ, Ananthakrishnan AN. Fatigue in IBD: epidemiology, pathophysiology and management. Nat Rev Gastroenterol Hepatol 2019;16:247–59. doi:10.1038/s41575-018-0091-9.
Canakis A, Qazi T. Sleep and fatigue in IBD: an unrecognized but important extra-intestinal manifestation. Curr Gastroenterol Rep 2020;22:8. doi:10.1007/s11894-020-0746-x.
Freeman D, Sheaves B, Goodwin GM, et al. The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis. Lancet Psychiatry 2017;4:749–58. doi:10.1016/S2215-0366(17)30328-0.
Holko P, Kawalec P, Sajak-Szczerba M, Avedano L, Mossakowska M. Indirect costs of inflammatory bowel diseases: a comparison of patient-reported outcomes across 12 European countries. Inflamm Bowel Dis 2022:izac144. doi:10.1093/ibd/izac144.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
