Article (Scientific journals)
External validation of a radiomic signature to predict p16 (HPV) status from standard CT images of anal cancer patients.
Leijenaar, Ralph T H; Walsh, Sean; Akshayaa Vaidyanathan et al.
2023In Scientific Reports, 13 (1), p. 7198
Peer Reviewed verified by ORBi
 

Files


Full Text
41598_2023_Article_34162.pdf
Publisher postprint (1.16 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Humans; Human Papillomavirus Viruses; Prognosis; Tomography, X-Ray Computed/methods; Retrospective Studies; Papillomavirus Infections; Oropharyngeal Neoplasms; Anus Neoplasms/diagnostic imaging; Multidisciplinary
Abstract :
[en] The paper deals with the evaluation of the performance of an existing and previously validated CT based radiomic signature, developed in oropharyngeal cancer to predict human papillomavirus (HPV) status, in the context of anal cancer. For the validation in anal cancer, a dataset of 59 patients coming from two different centers was collected. The primary endpoint was HPV status according to p16 immunohistochemistry. Predefined statistical tests were performed to evaluate the performance of the model. The AUC obtained here in anal cancer is 0.68 [95% CI (0.32-1.00)] with F1 score of 0.78. This signature is TRIPOD level 4 (57%) with an RQS of 61%. This study provides proof of concept that this radiomic signature has the potential to identify a clinically relevant molecular phenotype (i.e., the HPV-ness) across multiple cancers and demonstrates potential for this radiomic signature as a CT imaging biomarker of p16 status.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Leijenaar, Ralph T H;  Radiomics (Oncoradiomics SA), Liège, Belgium
Walsh, Sean;  Radiomics (Oncoradiomics SA), Liège, Belgium
Akshayaa Vaidyanathan;  Radiomics (Oncoradiomics SA), Liège, Belgium ; The D-Lab, Department of Precision Medicine, GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands
Aliboni, Lorenzo;  Radiomics (Oncoradiomics SA), Liège, Belgium
Sanchez, Victoria Lopez;  Radiomics (Oncoradiomics SA), Liège, Belgium
Leech, Michelle;  Applied Radiation Therapy, Discipline of Radiation Therapy, Trinity St. James's Cancer Institute, Trinity College, Dublin, Ireland
Joyce, Ronan;  Department of Radiation Oncology, St. Luke's Radiation Oncology Network and St James's Hospital, Dublin, Ireland
Gillham, Charles;  Department of Radiation Oncology, St. Luke's Radiation Oncology Network and St James's Hospital, Dublin, Ireland
Kridelka, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de gynécologie-obstétrique
Hustinx, Roland  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
Danthine, Denis ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic
Occhipinti, Mariaelena;  Radiomics (Oncoradiomics SA), Liège, Belgium
Vos, Wim;  Radiomics (Oncoradiomics SA), Liège, Belgium
Guiot, Julien  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Lambin, Philippe;  The D-Lab, Department of Precision Medicine, GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands ; Department of Radiology and Nuclear Medicine, GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands
Lovinfosse, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > > Service médical de médecine nucléaire et imagerie onco
More authors (6 more) Less
Language :
English
Title :
External validation of a radiomic signature to predict p16 (HPV) status from standard CT images of anal cancer patients.
Publication date :
03 May 2023
Journal title :
Scientific Reports
eISSN :
2045-2322
Publisher :
Springer Science and Business Media LLC, England
Volume :
13
Issue :
1
Pages :
7198
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 June 2023

Statistics


Number of views
49 (5 by ULiège)
Number of downloads
24 (1 by ULiège)

Scopus citations®
 
2
Scopus citations®
without self-citations
1
OpenCitations
 
0

Bibliography


Similar publications



Contact ORBi