Low Phase Angle Values Are Associated with Malnutrition according to the Global Leadership Initiative on Malnutrition Criteria in Kidney Transplant Candidates: Preliminary Assessment of Diagnostic Accuracy in the FRAILMar Study.
[en] Malnutrition has a negative impact on patients with chronic diseases and its early identification is a priority. The primary objective of this diagnostic accuracy study was to assess the performance of the phase angle (PhA), a bioimpedance analysis (BIA)-derived parameter, for malnutrition screening using the Global Leadership Initiative for Malnutrition (GLIM) criteria as the reference standard in patients with advanced chronic kidney disease (CKD) waiting for kidney transplantation (KT); criteria associated with low PhA in this population were also analyzed. Sensitivity, specificity, accuracy, positive and negative likelihood ratios, predictive values, and area under the receiver operating characteristic curve were calculated for PhA (index test) and compared with GLIM criteria (reference standard). Of 63 patients (62.9 years old; 76.2% men), 22 (34.9%) had malnutrition. The PhA threshold with the highest accuracy was ≤4.85° (sensitivity 72.7%, specificity 65.9%, and positive and negative likelihood ratios 2.13 and 0.41, respectively). A PhA ≤ 4.85° was associated with a 3.5-fold higher malnutrition risk (OR = 3.53 (CI95% 1.0-12.1)). Considering the GLIM criteria as the reference standard, a PhA ≤ 4.85° showed only fair validity for detecting malnutrition, and thus cannot be recommended as a stand-alone screening tool in this population.
Disciplines :
Geriatrics
Author, co-author :
Muñoz-Redondo, Elena ; Physical Medicine and Rehabilitation Department, Parc de Salut Mar (Hospital del Mar-Hospital de l'Esperança), 08003 Barcelona, Spain ; Rehabilitation Research Group, Hospital del Mar Medical Research Group, 08003 Barcelona, Spain ; PhD Program in Medicine, Department of Medicine, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
Morgado-Pérez, Andrea; Physical Medicine and Rehabilitation Department, Parc de Salut Mar (Hospital del Mar-Hospital de l'Esperança), 08003 Barcelona, Spain ; Rehabilitation Research Group, Hospital del Mar Medical Research Group, 08003 Barcelona, Spain
Pérez-Sáez, María-José ; Nephrology Department, Hospital del Mar, 08003 Barcelona, Spain ; Kidney Disease Research Group, Hospital del Mar Medical Research Group, 08003 Barcelona, Spain ; Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Dr Aiguader Building (Mar Campus), 08003 Barcelona, Spain
Faura, Anna; Nephrology Department, Hospital del Mar, 08003 Barcelona, Spain
Sanchez Rodriguez, Maria Dolores Carmen ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Tejero-Sánchez, Marta; Physical Medicine and Rehabilitation Department, Parc de Salut Mar (Hospital del Mar-Hospital de l'Esperança), 08003 Barcelona, Spain ; Rehabilitation Research Group, Hospital del Mar Medical Research Group, 08003 Barcelona, Spain
Meza-Valderrama, Delky ; Rehabilitation Research Group, Hospital del Mar Medical Research Group, 08003 Barcelona, Spain ; Physical Medicine and Rehabilitation Department, National Institute of Physical Medicine and Rehabilitation (INMFRE), Diagonal a la Universidad Tecnológica de Panamá, Panama City 0819, Panama
Muns, María Dolors; Department of Endocrinology and Nutrition, Hospital del Mar, 08003 Barcelona, Spain
Marco, Ester; Physical Medicine and Rehabilitation Department, Parc de Salut Mar (Hospital del Mar-Hospital de l'Esperança), 08003 Barcelona, Spain ; Rehabilitation Research Group, Hospital del Mar Medical Research Group, 08003 Barcelona, Spain ; Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Dr Aiguader Building (Mar Campus), 08003 Barcelona, Spain
Language :
English
Title :
Low Phase Angle Values Are Associated with Malnutrition according to the Global Leadership Initiative on Malnutrition Criteria in Kidney Transplant Candidates: Preliminary Assessment of Diagnostic Accuracy in the FRAILMar Study.
ISCIII - Carlos III Health Institute [ES] EU - European Union [BE]
Funding text :
This research was funded by FIS-FEDER PI19/00037 (ISCIII) and co-funded by the European Union; it was also supported by a Projecte Estrella de Millora de la Qualitat del Parc de Salut Mar. M.J-.P.-S has been granted by the Spanish Society of Transplant.
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