[en] Skin delivery is an exciting and challenging field. It is a promising approach for effective
drug delivery due to its ease of administration, ease of handling, high flexibility, controlled release, prolonged therapeutic effect, adaptability, and many other advantages. The main associated challenge, however, is low skin permeability. The skin is a healthy barrier that serves as the body’s primary defence mechanism against foreign particles. New advances in skin delivery (both topical and transdermal) depend on overcoming the challenges associated with drug molecule permeation and skin irritation. These limitations can be overcome by employing new approaches such as lipid nanosystems. Due to their advantages (such as easy scaling, low cost, and remarkable stability) thesesystems have attracted interest from the scientific community. However, for a successful formulation,
several factors including particle size, surface charge, components, etc. have to be understood and controlled. This review provided a brief overview of the structure of the skin as well as the different pathways of nanoparticle penetration. In addition, the main factors influencing the penetration of nanoparticles have been highlighted. Applications of lipid nanosystems for dermal and transdermal delivery, as well as regulatory aspects, were critically discussed.
Precision for document type :
Review article
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Akombaetwa, Nakamwi; Faculty of Pharmacy, Nutrition and Dietetics, Lusaka Apex Medical University, Lusaka 10101, Zambia
Ilangala Booka, Ange ; Université de Liège - ULiège > Freshwater and OCeanic science Unit of reSearch (FOCUS)
Lorraine Thom; Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa
Patrick B. Memvanga; Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa XI B.P. 212, Democratic Republic of the Congo
Bwalya Angel Witika; Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa
Aristote B. Buya; Faculty of Pharmaceutical Sciences, University of Kinshasa, Kinshasa XI B.P. 212, Democratic Republic of the Congo
Language :
English
Title :
Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications
Publication date :
2023
Journal title :
Pharmaceutics
ISSN :
1999-4923
Publisher :
MDPI AG
Special issue title :
Special Issue: Overcoming Physiological Barriers Using Lipid Nanosystems. Pharmaceutics
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