[en] The social soil-dwelling bacterium Myxococcus xanthus can form multicellular structures, known as fruiting bodies. Experiments in homogeneous environments have shown that this process is affected by the physicochemical properties of the substrate, but they have largely neglected the role of complex topographies. We experimentally demonstrate that the topography alters single-cell motility and multicellular organization in M. xanthus In topographies realized by randomly placing silica particles over agar plates, we observe that the cells' interaction with particles drastically modifies the dynamics of cellular aggregation, leading to changes in the number, size, and shape of the fruiting bodies and even to arresting their formation in certain conditions. We further explore this type of cell-particle interaction in a computational model. These results provide fundamental insights into how the environment topography influences the emergence of complex multicellular structures from single cells, which is a fundamental problem of biological, ecological, and medical relevance.
Disciplines :
Microbiology
Author, co-author :
Ramos, Corina H ; Facultad de Ciencias, Universidad Nacional Autónoma de México, Cd. de México, C.P. 4510, Mexico ; Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autónoma de México, Cd. de México, C.P. 04510, Mexico
Rodríguez-Sánchez, Edna ; Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autónoma de México, Cd. de México, C.P. 04510, Mexico
Del Angel, Juan Antonio Arias; Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autónoma de México, Cd. de México, C.P. 04510, Mexico
Arzola, Alejandro V ; Instituto de Física, Universidad Nacional Autónoma de México, Cd. de México, C.P. 04510, México
Benítez, Mariana ; Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autónoma de México, Cd. de México, C.P. 04510, Mexico
Escalante, Ana E; Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autónoma de México, Cd. de México, C.P. 04510, Mexico
Franci, Alessio ; Université de Liège - ULiège > Département d'électricité, électronique et informatique (Institut Montefiore) > Brain-Inspired Computing ; Facultad de Ciencias, Universidad Nacional Autónoma de México, Cd. de México, C.P. 4510, Mexico
Volpe, Giovanni ; Department of Physics, University of Gothenburg, Gothenburg, Sweden
Rivera-Yoshida, Natsuko ; Facultad de Ciencias, Universidad Nacional Autónoma de México, Cd. de México, C.P. 4510, Mexico. natsuko.rivera@iecologia.unam.mx n.riverayoshida@gmail.com ; Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autónoma de México, Cd. de México, C.P. 04510, Mexico
Language :
English
Title :
The environment topography alters the way to multicellularity in Myxococcus xanthus.
Publication date :
August 2021
Journal title :
Science Advances
eISSN :
2375-2548
Publisher :
American Association for the Advancement of Science, United States
KAW - Knut and Alice Wallenberg Foundation UNAM - National Autonomous University of Mexico CONACYT - Consejo Nacional de Ciencia y Tecnología ERC - European Research Council
Funding text :
Funding: This work was supported by PAPIIT-DGAPA-UNAM IN102420, PAPIIT-DGAPA-UNAM IN111919, Conacyt Ciencia Básica A1-S-10610, H2020 European Research Council (ERC) Starting Grant ComplexSwimmers (677511), and the Knut and Alice Wallenberg Foundation.
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