Myxococcus xanthus; evolutionary-developmental biology; morphogenesis; multicellularity; systems biology; Body Patterning; Morphogenesis; Myxococcus xanthus/growth & development; Biological Evolution; Ecology, Evolution, Behavior and Systematics; Molecular Medicine; Animal Science and Zoology; Genetics; Developmental Biology
Abstract :
[en] Development and evolution are dynamical processes under the continuous control of organismic and environmental factors. Generic physical processes, associated with biological materials and certain genes or molecules, provide a morphological template for the evolution and development of organism forms. Generic dynamical behaviors, associated with recurring network motifs, provide a temporal template for the regulation and coordination of biological processes. The role of generic physical processes and their associated molecules in development is the topic of the dynamical patterning module (DPM) framework. The role of generic dynamical behaviors in biological regulation is studied via the identification of the associated network motifs (NMs). We propose a joint DPM-NM perspective on the emergence and regulation of multicellularity focusing on a multicellular aggregative bacterium, Myxococcus xanthus. Understanding M. xanthus development as a dynamical process embedded in a physical substrate provides novel insights into the interaction between developmental regulatory networks and generic physical processes in the evolutionary transition to multicellularity.
Disciplines :
Microbiology
Author, co-author :
Guzmán-Herrera, Alejandra ; Departamento de Matemáticas, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico ; MRC Laboratory for Molecular Cell Biology, University College London, London, UK
Arias Del Angel, Juan A; Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autónoma de México, Mexico City, Mexico ; Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, Mexico City, Mexico ; Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico
Rivera-Yoshida, Natsuko; Departamento de Matemáticas, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico
Benítez, Mariana ; Laboratorio Nacional de Ciencias de la Sostenibilidad, Instituto de Ecología, Universidad Nacional Autónoma de México, Mexico City, Mexico ; Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, Mexico City, Mexico
Franci, Alessio ; Université de Liège - ULiège > Département d'électricité, électronique et informatique (Institut Montefiore) > Brain-Inspired Computing ; Departamento de Matemáticas, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City, Mexico
Language :
English
Title :
Dynamical patterning modules and network motifs as joint determinants of development: Lessons from an aggregative bacterium.
Publication date :
April 2021
Journal title :
Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
CONACYT - Consejo Nacional de Ciencia y Tecnología UNAM - Universidad Nacional Autónoma de México
Funding text :
During the peer review process, Juan A. Arias Del Angel, our dear friend and coauthor, passed away. He was intimately involved in the analyses, discussions, and writing of the manuscript. We dedicate this article to his memory. The authors would like to thank Stuart Newman for valuable feedback on the manuscript. A. G. H. is currently a doctoral student at University College London (UCL) and is funded by University College London (UCL) through an Overseas Research Scholarship and a Graduate Research Scholarship; and by Consejo Nacional de Ciencia y Tecnología (CONACyT; Scholarship Number 471963). J. A. D. A. was a doctoral student from Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM) funded by CONACyT (Scholarship Number 580236). N. R. Y. is funded by Programa de Becas Posdoctorales en la UNAM, A. F. and M. B. are funded by UNAM-DGAPA-PAPIIT, Grant IA105518. A. F. is also funded by CONACyT, Grant A1-S-10610.During the peer review process, Juan A. Arias Del Angel, our dear friend and coauthor, passed away. He was intimately involved in the analyses, discussions, and writing of the manuscript. We dedicate this article to his memory. The authors would like to thank Stuart Newman for valuable feedback on the manuscript. A. G. H. is currently a doctoral student at University College London (UCL) and is funded by University College London (UCL) through an Overseas Research Scholarship and a Graduate Research Scholarship; and by Consejo Nacional de Ciencia y Tecnología (CONACyT; Scholarship Number 471963). J. A. D. A. was a doctoral student from Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México (UNAM) funded by CONACyT (Scholarship Number 580236). N. R. Y. is funded by Programa de Becas Posdoctorales en la UNAM, A. F. and M. B. are funded by UNAM‐DGAPA‐PAPIIT, Grant IA105518. A. F. is also funded by CONACyT, Grant A1‐S‐10610.
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