Article (Scientific journals)
Cytokine-targeted therapies for asthma and COPD
Schleich, FLorence; Bougard, Nicolas; Moermans, Catherine et al.
2023In European Respiratory Review: an Official Journal of the European Respiratory Society, 32 (168)
Peer reviewed
 

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Abstract :
[en] Asthma affects over 300 million people worldwide and its prevalence is increasing. COPD is the third leading cause of death globally. Asthma and COPD are complex inflammatory diseases of the airways in which impaired host defences lead to increased susceptibility to pathogens, pollutants and allergens. There is a constant interplay between host and the environment. Environmental exposures can alter the lung microbiome and influence the development of sensitisation by disrupting normal immunoregulation. The underlying airway inflammation in severe asthma is heterogeneous, with upregulation of type 2 cytokines in most cases but increased neutrophilic inflammation and activated T-helper 17 mediated immunity in others. COPD may also comprise several different phentoypes that are driven by different molecular mechanisms or endotypes. This disease heterogeneity is affected by comorbidities, treatments and environmental exposures. Recent intervention trials have shed light on the pathways beyond type 2 inflammation that can lead to beneficial outcomes versus potentially deleterious effects. We have made a great deal of progress over the last 10 years in terms of immunology and the pathophysiology of asthma and this has led to the development of novel treatments and major improvements in severe asthma outcomes. In COPD, however, no targeted treatments have demonstrated great improvements. This article reviews the mechanism of action and efficacy of the available biologics in asthma and COPD. Copyright ©The authors 2023.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Schleich, FLorence ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Bougard, Nicolas ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Moermans, Catherine  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Sabbe, M.;  Respiratory Medicine, CHU of Liege, Belgium
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Language :
English
Title :
Cytokine-targeted therapies for asthma and COPD
Publication date :
April 2023
Journal title :
European Respiratory Review: an Official Journal of the European Respiratory Society
ISSN :
0905-9180
eISSN :
1600-0617
Publisher :
NLM (Medline)
Volume :
32
Issue :
168
Peer reviewed :
Peer reviewed
Available on ORBi :
since 25 May 2023

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