Article (Scientific journals)
Sinonasal disease among patients with primary ciliary dyskinesia: an international study
Lam, Yin Ting; Papon, Jean-François; Alexandru, Mihaela et al.
2023In ERJ Open Research, 9 (3), p. 00701-2022
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Keywords :
Pulmonary and Respiratory Medicine
Abstract :
[en] BackgroundSinonasal symptoms are a common feature of primary ciliary dyskinesia (PCD); however, literature about their severity and frequency, particularly during the life course, is scarce. Using baseline data from the Ear, nose and throat (ENT) Prospective International Cohort of PCD patients, we describe sinonasal disease in PCD.MethodsWe included participants who had a routine sinonasal examination during which they completed a symptoms questionnaire. We compared frequency of reported symptoms and examination findings among children and adults, and identified characteristics potentially associated with higher risk of sinonasal disease using ordinal regression.Results12 centres contributed 384 participants; median age was 16 years (IQR 9–22), and 54% were male. Chronic nasal problems were the most common feature, reported by 341 (89%). More adults (33; 24%) than children (10; 4%) described hyposmia. Quality of life was moderately affected by rhinosinusitis among 136 participants with completed SNOT-22 questionnaires (median score 31; IQR 23–45). Examinations revealed nasal polyps among 51 of 345 participants (15%) and hypertrophic inferior nasal turbinates among 127 of 341 participants (37%). Facial pain was detected in 50 of 342 participants (15%). Nasal polyps, hypertrophic turbinates, deviated septum and facial pain were found more commonly in adults than children. The only characteristic associated with higher risk of sinonasal disease was age 10 years and older.ConclusionsBased on our findings, regular sinonasal examinations are relevant for patients with PCD of all ages. There is a need for improved management of sinonasal disease supported by evidence-based guidelines.
Disciplines :
Otolaryngology
Author, co-author :
Lam, Yin Ting 
Papon, Jean-François
Alexandru, Mihaela 
Anagiotos, Andreas
Armengot, Miguel
Boon, Mieke
Burgess, Andrea
Crowley, Suzanne 
Dheyauldeen, Sinan Ahmed D.
Emiralioglu, Nagehan 
Erdem Eralp, Ela
van Gogh, Christine
Gokdemir, Yasemin
Gunaydın, Onder
Haarman, Eric G.
Harris, Amanda 
Hayn, Isolde
Ismail-Koch, Hasnaa
Karadag, Bülent 
Kempeneers, Céline  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Kim, Sookyung
Latzin, Philipp 
Lorent, Natalie 
Ozcelik, Ugur
Pioch, Charlotte
Poirrier, Anne-Lise  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'ORL, d'audiophonologie et de chir. cervico-faciale
Reula, Ana
Roehmel, Jobst 
Yiallouros, Panayiotis
Goutaki, Myrofora 
Ademhan, Dilber
Alexandru, Mihaela
Anagiotos, Andreas
Armengot, Miguel
Benchimol, Lionel  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'ORL, d'audiophonologie et de chir. cervico-faciale
Beule, Achim G.
Bon, Irma
Boon, Mieke
Bullo, Marina
Burgess, Andrea
CALMES, Doriane ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Casaulta, Carmen
Caversaccio, Marco
Caversaccio, Nathalie
Crestani, Bruno
Crowley, Suzanne
Dheyauldeen, Sinan Ahmed D.
Diepenhorst, Sandra
Emiralioglu, Nagehan
Eralp, Ela Erdem
Ergenekon, Pinar
Feyaerts, Nathalie
Georgiou, Gavriel
Glen, Amy
Gogh, Christine van
Gokdemir, Yasemin
Goutaki, Myrofora
Gunaydın, Onder
Haarman, Eric G.
Harris, Amanda
Hayn, Isolde
Helms, Simone
Hool, Sara-Lynn
Honoré, Isabelle
Ismail Koch, Hasnaa
Karadag, Bülent
Kempeneers, Céline  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Kennelly, Synne
Kieninger, Elisabeth
Kim, Sookyung
Kouis, Panayiotis
Lam, Yin Ting
Latzin, Philipp
Legendre, Marie
Lorent, Natalie
Lucas, Jane S.
Maitre, Bernard
McEvoy, Alison
Mitri-Frangieh, Rana
Montani, David
Müller, Loretta
Muñoz, Noelia
Omran, Heymut
Ozcelik, Ugur
Ozsezen, Beste
Packham, Samantha
Papon, Jean-François
PAULY, Clara ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie
Pioch, Charlotte
Poirrier, Anne-Lise  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'ORL, d'audiophonologie et de chir. cervico-faciale
Raidt, Johanna
Reula, Ana
Rinkel, Rico
Roehmel, Jobst
Schramm, Andre
Thouvenin, Guillaume
Walker, Woolf T
Wilkins, Hannah
Yiallouros, Panayiotis
Yumusakhuylu, Ali Cemal
Ziegahn, Niklas
More authors (91 more) Less
Language :
English
Title :
Sinonasal disease among patients with primary ciliary dyskinesia: an international study
Publication date :
May 2023
Journal title :
ERJ Open Research
eISSN :
2312-0541
Publisher :
European Respiratory Society (ERS)
Volume :
9
Issue :
3
Pages :
00701-2022
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
SNF - Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
Available on ORBi :
since 24 May 2023

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