[en] N-Acyl dehydroalanines have shown free radical scavenging activity. They react with and scavenge mainly oxygen-derived free radicals such as the superoxide anion (O2-.) and the hydroxyl radical (HO.). Ortho-methoxyphenylacetyl dehydroalanine (AD-20) protects total-body irradiated mice against the toxicity induced by X-rays when delivered as a single dose of 700 rads in a short period of time. This degree of protection was of the same order of magnitude as that obtained with the aminothiol S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR-2721). The radioprotection of AD-20 is extended to all other doses of X-rays tested (from 600 to 800 rads). Furthermore, AD-20 inhibits the development of thymic lymphomas in C57Bl/Ka mice undergoing a leukaemogenic course of irradiation (4 x 175 rads applied at weekly intervals). We postulate that AD-20 may act as a radioprotector and anticarcinogenic agent, most probably by inactivating the oxygen-derived free radicals formed during water radiolysis.
Disciplines :
Oncology
Author, co-author :
Buc-Calderon, P.; Unité de Biochimie Toxicologique et Cancérologique, Ecole de Pharmacie, UCL 7369, Université Catholique de Louvain, Brussels, Belgium
Defresne, Marie-Paule ; Université de Liège - ULiège > Département des sciences précliniques MI > Histologie - Cytologie ; Unité de Biochimie Toxicologique et Cancérologique, Ecole dc Pharmacie, Université Catholique de Louvain, B-1200 Brussels, Belgium
Barvais, C.; Unité de Biochimie Toxicologique et Cancérologique, Ecole dc Pharmacie, Université Catholique de Louvain, B-1200 Brussels, Belgium
ROBERFROID, M.; UCL - Université Catholique de Louvain [BE] > Ecole de Pharmacie > Unité de Biochimie Toxicologique et Cancérologique
Language :
English
Title :
N-acyl dehydroalanines protect from radiation toxicity and inhibit radiation carcinogenesis in mice
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