mobile health; patient-reported outcomes; real-world data; rhinitis
Abstract :
[en] INTRODUCTION: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms. METHODS: We analyzed MASK-air® data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7 days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results. RESULTS: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age ± SD = 39.1 ± 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. CONCLUSIONS: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Sousa-Pinto, Bernardo; MEDCIDS - Department of Community Medicine, Information and Health Decision ; CINTESIS - Center for Health Technology and Services Research, University of ; RISE - Health Research Network, University of Porto, Porto, Portugal.
Schünemann, Holger J; Department of Health Research Methods, Evidence, and Impact & Department of
Sá-Sousa, Ana; MEDCIDS - Department of Community Medicine, Information and Health Decision ; CINTESIS - Center for Health Technology and Services Research, University of ; RISE - Health Research Network, University of Porto, Porto, Portugal.
Vieira, Rafael José ; MEDCIDS - Department of Community Medicine, Information and Health Decision ; CINTESIS - Center for Health Technology and Services Research, University of ; RISE - Health Research Network, University of Porto, Porto, Portugal.
Amaral, Rita ; MEDCIDS - Department of Community Medicine, Information and Health Decision ; CINTESIS - Center for Health Technology and Services Research, University of ; RISE - Health Research Network, University of Porto, Porto, Portugal.
Anto, Josep M; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain. ; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. ; Universitat Pompeu Fabra (UPF), Barcelona, Spain. ; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Klimek, Ludger ; Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, ; Center for Rhinology and Allergology, Wiesbaden, Germany.
Czarlewski, Wienczyslawa; Medical Consulting Czarlewski, Levallois, France.
Mullol, Joaquim; Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Clinical &
Pfaar, Oliver ; Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and
Bedbrook, Anna; ARIA, Montpellier, France.
Brussino, Luisa; Department of Medical Sciences, Allergy and Clinical Immunology Unit, University
Kvedariene, Violeta; Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, ; Institute of Clinical medicine, Clinic of Chest diseases and Allergology, Faculty
Larenas-Linnemann, Désirée E; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and
Okamoto, Yoshitaka; Chiba University Hospital and Chiba Rosai Hospital, Chiba, Japan.
Ventura, Maria Teresa; Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari,
Agache, Ioana ; Transylvania University Brasov, Brasov, Romania.
Ansotegui, Ignacio J; Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao,
Bergmann, Karl C ; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP
Bosnic-Anticevich, Sinthia; Quality Use of Respiratory Medicine Group, Woolcock Institute of Medical
Canonica, G Walter; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. ; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center
Cardona, Victoria; Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron &
Carreiro-Martins, Pedro ; Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar ; NOVA Medical School/Comprehensive Health Research Centre (CHRC), Lisbon
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Cecchi, Lorenzo ; SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
Chivato, Tomas; School of Medicine, University CEU San Pablo, Madrid, Spain.
Chu, Derek K; Department of Health Research Methods, Evidence, and Impact & Department of
Cingi, Cemal ; ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir
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Del Giacco, Stefano ; Department of Medical Sciences and Public Health and Unit of Allergy and Clinical
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Eklund, Patrik; Department of Computing Science, Umeå University, Umeå, Sweden.
Fokkens, Wytske J ; Department of Otorhinolaryngology, Amsterdam University Medical Centres, location
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Haahtela, Tari ; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki
Ivancevich, Juan Carlos; Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
Ispayeva, Zhanat; Kazakhstan Association of Allergology and Clinical Immunology, Department of
Jutel, Marek; Department of Clinical Immunology, Wrocław Medical University, and ALL-MED
Kuna, Piotr; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital,
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Kraxner, Helga; Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University,
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Lipworth, Brian; Scottish Centre for Respiratory Research, Cardiovascular & Diabetes Medicine,
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Makris, Michael; Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology,
Monti, Riccardo; Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico
Morais-Almeida, Mario ; Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
Mösges, Ralph; IMSB, Medical Faculty, University at Cologne, and ClinCompetence Cologne GmbH,
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Papadopoulos, Nikolaos G ; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
Patella, Vincenzo ; Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria
Pham-Thi, Nhân; Ecole Polytechnique Palaiseau, IRBA (Institut de Recherche bio-Médicale des
Regateiro, Frederico S; Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de ; Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, ; Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research
Reitsma, Sietze; Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC,
Rouadi, Philip W ; Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University ; Department of Otorhinolaryngology-Head and Neck Surgery, Dar Al Shifa Hospital
Samolinski, Boleslaw; Department of Prevention of Environmental Hazards, Allergology and Immunology,
Sheikh, Aziz; Usher Institute, The University of Edinburgh, Edinburgh, UK.
Sova, Milan; Department of Respiratory Medicine and Tuberculosis, University Hospital, Brno,
Todo-Bom, Ana; Imunoalergologia, Centro Hospitalar Universitário de Coimbra, Faculty of
Taborda-Barata, Luis; CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, ; UBIAir - Clinical & Experimental Lung Centre, University of Beira Interior, ; Department of Immunoallergology, Cova da Beira University Hospital Centre,
Toppila-Salmi, Sanna ; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki
Sastre, Joaquin; Fundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of
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