[en] Zeb2 (Sip1, Zfhx1b) is a transcription factor that plays essential role in neuronal development. Sip1 mutation in humans was shown to cause Mowat-Wilson syndrome, a syndromic form of Hirschprung's disease. Affected individuals exhibit multiple severe neurodevelopmental defects. Zeb2 can act as both transcriptional repressor and activator. It controls expression of a wide number of genes that regulate various aspects of neuronal development. This review addresses the molecular pathways acting downstream of Zeb2 that cause brain development disorders.
Epifanova, Ekaterina ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques ; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin,
Babaev, Alexey; Lobachevsky State University of Nizhny Novgorod, Gagarina ave 23, 603950 Nizhny
Newman, Andrew G; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin,
Tarabykin, Victor; Institute of Cell Biology and Neurobiology, Charité - Universitätsmedizin Berlin,
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