Neocortex expansion in development and evolution-from genes to progenitor cell biology.

[en] The evolutionary expansion of the neocortex, the seat of higher cognitive functions in humans, is primarily due to an increased and prolonged proliferation of neural progenitor cells during development. Basal progenitors, and in particular basal radial glial cells, are thought to have a key role in the increased generation of neurons that constitutes a foundation of neocortex expansion. Recent studies have identified primate-specific and human-specific genes and changes in gene expression that promote increased proliferative capacity of cortical progenitors. In many cases, the cell biological basis underlying this increase has been uncovered. Model systems such as mouse, ferret, nonhuman primates, and cerebral organoids have been used to establish the relevance of these genes for neocortex expansion.

Disciplines :

Neurology

Author, co-author :

Pinson, Anneline ; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany. Electronic address: pinson@mpi-cbg.de

Huttner, Wieland B; Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany. Electronic address: huttner@mpi-cbg.de

Language :

English

Title :

Neocortex expansion in development and evolution-from genes to progenitor cell biology.

Publication date :

December 2021

Journal title :

Current Opinion in Cell Biology

ISSN :

0955-0674

Publisher :

Elsevier Ltd, England

Volume :

Pages :

9 - 18

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0955067421000582?httpAccept=text/xml

Funders :

MPG - Max Planck Society

Funding text :

The authors apologize to all researchers whose work could not be cited because of space limitation. The authors thank Takashi Namba, Nereo Kalebic, Lei Xing, and Samir Vaid for critically reading the manuscript.

Available on ORBi :

since 22 May 2023

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