Article (Scientific journals)
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis
Bousquet, J.; Melén, E.; Haahtela, T. et al.
2023In Allergy
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Keywords :
asthma; IL-33; multimorbidity; rhinitis; Toll-like receptors
Abstract :
[en] Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases. © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Bousquet, J.;  Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Allergology and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Berlin, Germany, University Hospital Montpellier, Montpellier, France, Inserm, Equipe d’Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France
Melén, E.;  Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden, Sach´s Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden
Haahtela, T.;  Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland
Koppelman, G.H.;  Department of Pediatric Pulmonology and Pediatric Allergology, GRIAC Research Institute, University Medical Center Groningen, Beatrix Children's Hospital, University of Groningen, Groningen, Netherlands
Togias, A.;  Division of Allergy, Immunology, and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States
Valenta, R.;  Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
Akdis, C.A.;  Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Czarlewski, W.;  Medical Consulting Czarlewski, Levallois, France, MASK-air, Montpellier, France
Rothenberg, M.;  Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States
Valiulis, A.;  Institute of Clinical Medicine and Institute of Health Sciences, Vilnius, Lithuania, Medical Faculty of Vilnius University, Vilnius, Lithuania
Wickman, M.;  Institute of Environmental medicine, Karolinska Institutet, Stockholm, Sweden
Akdis, M.;  Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Aguilar, D.;  6AM Data Mining, Barcelona, Spain
Bedbrook, A.;  MASK-air, Montpellier, France, ARIA, Montpellier, France
Bindslev-Jensen, C.;  Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark, Odense Research Center for Anaphylaxis « ORCA », Odense, Denmark
Bosnic-Anticevich, S.;  Quality Use of Respiratory Medicines Group, Woolcock Institute of Medical Research, Sydney, NSW, Australia, Sydney Local Health District, Sydney, NSW, Australia, Sydney Pharmacy School, The University of Sydney, Sydney, NSW, Australia
Boulet, L.P.;  Quebec Heart and Lung Institute, Laval University, Quebec City, QC, Canada
Brightling, C.E.;  Institute of Lung Health, NIHR Biomedical Research Centre, Department of Respiratory and Infection Sciences, University of Leicester, Leicester, United Kingdom
Brussino, L.;  Department of Medical Sciences, University of Torino, Torino, Italy, Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy
Burte, E.;  Inserm, Equipe d’Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France, Université Paris-Saclay, UVSQ, UnivParis-Sud, Villejuif, France
Bustamante, M.;  Universitat Pompeu Fabra (UPF), Barcelona, Spain, ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Canonica, G.W.;  Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy, Personalized medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Cecchi, L.;  SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy
Celedon, J.C.;  Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United States
Chaves Loureiro, C.;  Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Costa, E.;  UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal
Cruz, A.A.;  Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Bahia, Salvador, Brazil
Erhola, M.;  Pirkanmaa Welfare district, Tampere, Finland
Gemicioglu, B.;  Department of Pulmonary Diseases, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey
Fokkens, W.J.;  Department of Otorhinolaryngology, Amsterdam University Medical Centres, Amsterdam, Netherlands
Garcia-Aymerich, J.;  Universitat Pompeu Fabra (UPF), Barcelona, Spain, ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain
Guerra, S.;  Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, United States
Heinrich, J.;  Ludwig Maximilians University Munich, University Hospital Munich - Instituteand Outpatient Clinic for Occupationa, Social and Environmental Medicine, Munich, Germany
Ivancevich, J.C.;  Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina
Keil, T.;  Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany, Institute for Clinical Epidemiology and Biometry, University of Wuerzburg, Wuerzburg, Germany, State Institute of Health, Bavarian Health and Food Safety Authority, Erlangen, Germany
Klimek, L.;  Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany, Center for Rhinology and Allergology, Wiesbaden, Germany
Kuna, P.;  Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Kupczyk, M.;  Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Kvedariene, V.;  Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Larenas-Linnemann, D.E.;  Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
Lemonnier, N.;  Institute for Advanced Biosciences, UGA - INSERM U1209 - CNRS UMR5309, La Tronche, Site Santé, France
Lodrup Carlsen, K.C.;  Department of Paediatrics, Oslo University Hospital, Oslo, Norway
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Makela, M.;  Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland
Makris, M.;  Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece
Maurer, M.;  Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Allergology and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Berlin, Germany
Momas, I.;  Department of Public Health and Health Products, Paris Descartes University-Sorbonne Paris Cité, Paris, EA 4064, France, Paris Municipal Department of Social Action, Childhood, and Health, Paris, France
Morais-Almeida, M.;  Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal
Mullol, J.;  ENT Department, Rhinology Unit & Smell Clinic, Hospital Clínic, Barcelona, Spain, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain
Naclerio, R.N.;  Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States
Nadeau, K.;  Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, United States
Nadif, R.;  Inserm, Equipe d’Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France, Université Paris-Saclay, UVSQ, UnivParis-Sud, Villejuif, France
Niedoszytko, M.;  Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
Okamoto, Y.;  Chiba Rosai Hospital, Chiba, Japan, Chiba University Hospital, Chiba, Japan
Ollert, M.;  Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark, Odense Research Center for Anaphylaxis « ORCA », Odense, Denmark, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg
Papadopoulos, N.G.;  Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Passalacqua, G.;  Allergy and Respiratory Diseases, IRCCS Policlinico San Martino - University of Genoa, Genoa, Italy
Patella, V.;  Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Salerno, Battipaglia, Italy, Agency of Health ASL, Salerno, Italy, Postgraduate Programme in Allergy and Clinical Immunology, University of Naples Federico II, Naples, Italy
Pawankar, R.;  Department of Pediatrics, Nippon Medical School, Tokyo, Japan
Pham-Thi, N.;  Ecole Polytechnique de Palaiseau, Palaiseau, France, IRBA (Institut de Recherche Bio-Médicale des Armées), Brétigny sur Orge, France, Université Paris Cité, Paris, France
Pfaar, O.;  Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany
Regateiro, F.S.;  Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, Coimbra Institute for Clinical and Biomedical Research (ICBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal, Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Ring, J.;  Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany, Christine Kühne Center for Allergy Research and Education (CK-Care), Davos, Switzerland
Rouadi, P.W.;  Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon, Department of Otorhinolaryngology-Head and Neck Surgery, Dar Al Shifa Hospital, Salmiya, Kuwait
Samolinski, B.;  Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland
Sastre, J.;  Allergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid, CIBERES-ISCIII, Madrid, Spain
Savouré, M.;  Inserm, Equipe d’Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France, Université Paris-Saclay, UVSQ, UnivParis-Sud, Villejuif, France, French Environment and Energy Management Agency, Angers, France
Scichilone, N.;  PROMISE Department, University of Palermo, Palermo, Italy
Shamji, M.H.;  National Heart and Lung Institute, Imperial College, London, United Kingdom, NIHR Imperial Biomedical Research Centre, London, United Kingdom
Sheikh, A.;  Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom
Siroux, V.;  INSERM, Université Grenoble Alpes, IAB, U 1209, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Université Joseph Fourier, Grenoble, France
Sousa-Pinto, B.;  MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences
Faculty of Medicine, University of Porto;  Porto, Portugal, CINTESIS@RISE– Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Standl, M.;  Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, German Center of Lung Research (DZL), Munich, Germany
Sunyer, J.;  Universitat Pompeu Fabra (UPF), Barcelona, Spain, ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Taborda-Barata, L.;  Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal, UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Toppila-Salmi, S.;  Skin and Allergy Hospital, Helsinki University Hospital, and University of Helsinki, Helsinki, Finland
Torres, M.J.;  Allergy Unit, Málaga Regional University Hospital of Málaga, Malaga University, ARADyAL, Malaga, Spain
Tsiligianni, I.;  International Primary Care Respiratory Group IPCRG, Aberdeen, United Kingdom, Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece
Valovirta, E.;  Department of Lung Diseases and Clinical Allergology, University of Turku, Turku, Finland
Vandenplas, O.;  Department of Chest Medicine, Centre Hospitalier Universitaire UCL, Namur, Belgium, Université Catholique de Louvain, Yvoir, Belgium
Ventura, M.T.;  Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy, Institute of Sciences of Food Production, National Research Council (ISPA-CNR), Bari, Italy
Weiss, S.;  Harvard Medical School and Channing Division of Network Medicine, Boston, United States
Yorgancioglu, A.;  Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
Zhang, L.;  Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital and Beijing Institute of Otolaryngology, Beijing, China
Abdul Latiff, A.H.;  Allergy & Immunology Centre, Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
Aberer, W.;  Department of Dermatology, Medical University of Graz, Graz, Austria
Agache, I.;  Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania
Al-Ahmad, M.;  Microbiology Department, College of Medicine, Kuwait University, Kuwait City, Kuwait
Alobid, I.;  Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, Centro Médico Teknon, Barcelona, Spain
Ansotegui, I.J.;  Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain
Arshad, S.H.;  Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, David Hide Asthma and Allergy Research Centre, Isle of Wight, United Kingdom
Asayag, E.;  Argentine Society of Allergy and Immunopathology, Buenos Aires, Argentina
Barbara, C.;  Portuguese National Programme for Respiratory Diseases, Direção -Geral da Saúde, Faculdade de Medicina de Lisboa, Instituto de Saúde Ambiental, Lisbon, Portugal
Baharudin, A.;  Department of Otorhinolaryngology, Head and Neck, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
Battur, L.;  Mongolian Association of Hospital Managers, Ulaanbaatar, Mongolia
Bennoor, K.S.;  Department of Respiratory Medicine, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh
Berghea, E.C.;  Department of Pediatrics, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Bergmann, K.C.;  Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Allergology and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Berlin, Germany
Bernstein, D.;  Division of Immunology, Allergy and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States
Bewick, M.;  University of Central Lancashire Medical School, Preston, United Kingdom
Blain, H.;  Department of Geriatrics, Montpellier University Hospital, MUSE, Montpellier, France
Bonini, M.;  Department of Cardiovascular and Respiratory Sciences, Universita Cattolica del Sacro Cuore, Rome, Italy, Department of Neurological, ENT and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli – IRCCS, Rome, Italy, National Heart and Lung Institute (NHLI), Imperial College London, London, United Kingdom
Braido, F.;  Respiratory Clinic, Department of Internal Medicine, University of Genoa, Genoa, Italy, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
Buhl, R.;  Department of Pulmonary Medicine, Mainz University Hospital, Mainz, Germany
Bumbacea, R.S.;  Department of Allergy, "Carol Davila" University of Medicine and Pharmacy Bucharest, Bucharest, Romania
Bush, A.;  Imperial College and Royal Brompton Hospital, London, United Kingdom
Calderon, M.;  Imperial College and National Heart and Lung Institute, London, United Kingdom
Calvo-Gil, M.;  Pediatrics Department, Universidad Austral de Chile, Valvidia, Chile
Camargos, P.;  Department of Pediatrics, Medical School, Federal University of Minas Gerais, Belo Horizonte, Brazil
Caraballo, L.;  Institute for Immunological Research, University of Cartagena, Campus de Zaragocilla, Edificio Biblioteca Primer piso, Cartagena, Colombia
Cardona, V.;  Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, ARADyAL Research Network, Barcelona, Spain
Carr, W.;  Allergy & Asthma Associates of Southern California, A Medical Group, Southern California Research, Mission Viejo, CA, United States
Carreiro-Martins, P.;  NOVA Medical School/Comprehensive Health Research Centre (CHRC), Lisbon, Portugal, Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal
Casale, T.;  Division of Allergy/Immunology, University of South Florida, Tampa, FL, United States
Cepeda Sarabia, A.M.;  Allergy and Immunology Laboratory, Metropolitan University, Simon Bolivar University, Barranquilla, Colombia, SLaai, Sociedad Latinoamericana de Allergia, Asma e Immunologia, Barranquilla, Colombia
Chandrasekharan, R.;  Department of ENT, Badr al Samaa Hospital, Salalah, Oman
Charpin, D.;  Clinique des Bronches, Allergie et Sommeil, Hôpital Nord, Marseille, France
Chen, Y.Z.;  The Capital Institute of Pediatrics, Chaoyang district, Beijing, China
Cherrez-Ojeda, I.;  Universidad Espíritu Santo, Samborondón, Ecuador, Respiralab Research Group, Guayas, Guayaquil, Ecuador
Chivato, T.;  School of Medicine, University CEU San Pablo, Madrid, Spain
Chkhartishvili, E.;  David Tatishvili Medical Center
David Tvildiani Medical University-AIETI Medical School, Tbilisi;  Georgia
Christoff, G.;  Faculty of Public Health, Medical University – Sofia, Sofia, Bulgaria
Chu, D.K.;  Department of Health Research Methods, Evidence, and Impact & Department of Medicine, McMaster University, Hamilton, ON, Canada
Cingi, C.;  Medical Faculty, ENT Department, Eskisehir Osmangazi University, Eskisehir, Turkey
Correia de Sousa, J.;  School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal
Corrigan, C.;  Division of Asthma, Allergy & Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom
Custovic, A.;  National Heart and Lung Institute, Imperial College London, London, United Kingdom
D’Amato, G.;  Division of Respiratory and Allergic Diseases, Hospital 'A Cardarelli', University of Naples Federico II, Naples, Italy
Del Giacco, S.;  Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy
De Blay, F.;  Allergy Division, Chest Disease Department, University Hospital of Strasbourg, Strasbourg, France, Federation of Translational Medicine, University of Strasbourg, Strasbourg, France
Devillier, P.;  VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France
Didier, A.;  Department of Respiratory Diseases, Larrey Hospital, Toulouse University Hospital, Toulouse, France
do Ceu Teixeira, M.;  Dr Agostinho Neto University hospital, Praia, Cape Verde, Immunology, Faculty of Medicine, Cabo Verde University, Praia, Cape Verde
Dokic, D.;  Medical Faculty Skopje, University Clinic of Pulmonology and Allergy, Skopje, North Macedonia
Douagui, H.;  Service de Pneumo-Allergologie, Centre Hospitalo-Universitaire de Béni-Messous, Algiers, Algeria
Doulaptsi, M.;  Department of Otorhinolaryngology Head and Neck Surgery, University Hospital of Crete, Heraklion, Crete, Greece
Durham, S.;  Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
Dykewicz, M.;  Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, United States
Eiwegger, T.;  The Hospital for Sick Children, Department of Paediatrics, Division of Clinical Immunology and Allergy, Food allergy and Anaphylaxis Program, The University of Toronto, Toronto, ON, Canada
El-Sayed, Z.A.;  Pediatric Allergy, Immunology and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt
Emuzyte, R.;  Clinic of Children's Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Fiocchi, A.;  Allergy, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
Fyhrquist, N.;  Institute of Environmental medicine, Karolinska Institutet, Stockholm, Sweden
Gomez, R.M.;  School of Health Sciences, Catholic University of Salta, Salta, Argentina
Gotua, M.;  Center of Allergy and Immunology, David Tvildiani Medical University, Tbilisi, Georgia
Guzman, M.A.;  Immunology and Allergy Division, Clinical Hospital, University of Chile, Santiago, Chile
Hagemann, J.;  Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany
Hamamah, S.;  Biology of Reproduction department, INSERM 1203, University hospital, Montpellier, France
Halken, S.;  Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark
Halpin, D.M.G.;  University of Exeter Medical School, College of Medicine and Health, University of Exeter, Devon, Exeter, United Kingdom
Hofmann, M.;  Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin Institute of Health, Berlin, Germany
Hossny, E.;  Pediatric Allergy, Immunology and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt
Hrubiško, M.;  Department of Clinical Immunology and Allergy, Oncology Institute of St Elisabeth, Bratislava, Slovakia
Irani, C.;  Department of Internal Medicine and Infectious Diseases, St Joseph University, Hotel Dieu de France Hospital, Beirut, Lebanon
Ispayeva, Z.;  Kazakhstan Association of Allergology and Clinical Immunology, Department of Allergology and Clinical Immunology of the Kazakh National Medical University, Almaty, Kazakhstan
Jares, E.;  Servicio de Alergia, Consultorios Médicos Privados, Buenos Aires, Argentina
Jartti, T.;  EDEGO Research Unit, University of Oulu, Oulu, Finland
Jassem, E.;  Department of Pneumology, Medical University of Gdańsk, Gdansk, Poland
Julge, K.;  Tartu University Institute of Clinical Medicine, Children's Clinic, Tartu, Estonia
Just, J.;  Sorbonne université, Hôpital américain de Paris, Neuilly, France
Jutel, M.;  Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland, ALL-MED Medical Research Institute, Wroclaw, Poland
Kaidashev, I.;  Poltava State Medical University, Poltava, Ukraine
Kalayci, O.;  Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey
Kalyoncu, A.F.;  School of Medicine, Department of Chest Diseases, Immunology and Allergy Division, Hacettepe University, Ankara, Turkey
Kardas, P.;  Department of Family Medicine, Medical University of Lodz, Lodz, Poland
Kirenga, B.;  Makerere University Lung Institute, Kampala, Uganda
Kraxner, H.;  Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary
Kull, I.;  Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden, Sach´s Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden
Kulus, M.;  Department of Pediatric Respiratory Diseases and Allergology, Medical University of Warsaw, Warsaw, Poland
La Grutta, S.;  Institute of Translational Pharmacology, National Research Council, Palermo, Italy
Lau, S.;  Department of Paediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité Universitätsmedizin, Berlin, Germany
Le Tuyet Thi, L.;  University of Medicine and Pharmacy, Hochiminh City, Viet Nam
Levin, M.;  Division Paediatric Allergology, University of Cape Town, Cape Town, South Africa
Lipworth, B.;  Scottish Centre for Respiratory Research, Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, United Kingdom
Lourenço, O.;  Faculty of Health Sciences and CICS – UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Mahboub, B.;  Department of Pulmonary Medicine, Rashid Hospital, Dubai, United Arab Emirates
Martinez-Infante, E.;  Hospital San Luca, Oaxaca, Mexico
Matricardi, P.;  Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany
Miculinic, N.;  Croatian Pulmonary Society, Zagreb, Croatia
Migueres, N.;  Allergy Division, Chest Disease Department, University Hospital of Strasbourg, Strasbourg, France
Mihaltan, F.;  National Institute of Pneumology M Nasta, Bucharest, Romania
Mohammad, Y.;  National Center for Research in Chronic Respiratory Diseases, Tishreen University School of Medicine, Latakia, Syrian Arab Republic, Syrian Private University, Damascus, Syrian Arab Republic
Moniuszko, M.;  Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystock, Poland
Montefort, S.;  Department of Medicine, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
Neffen, H.;  Center of Allergy, Immunology and Respiratory Diseases, Santa Fe, Argentina
Nekam, K.;  Hungarian Allergy Association, Budapest, Hungary
Nunes, E.;  Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique
Nyembue Tshipukane, D.;  ENT Department, University Hospital of Kinshasa, Kinshasa, Congo
O’Hehir, R.;  Allergy, Asthma and Clinical Immunology, Alfred Health and Department of Immunology, Central Clinical School, Monash University, Melbourne, VIC, Australia
Ogulur, I.;  Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
Ohta, K.;  Japan Anti-Tuberculosis Association (JATA), Fukujuji Hospital, Tokyo, Japan
Okubo, K.;  Department of Otolaryngology, Nippon Medical School, Tokyo, Japan
Ouedraogo, S.;  Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle, Ouagadougou, Burkina Faso
Olze, H.;  Berlin Institute of Health, Berlin, Germany
Pali-Schöll, I.;  Department of Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine, Medical University, and University of Vienna, Vienna, Austria
Palomares, O.;  Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, Madrid, Spain
Palosuo, K.;  Department of Dermatology, University of Helsinki and Hospital for Skin and Allergic Diseases, Helsinki, Finland
Panaitescu, C.;  OncoGen Center, County Clinical Emergency Hospital "Pius Branzeu," and University of Medicine and Pharmacy V Babes, Timisoara, Romania
Panzner, P.;  Department of Immunology and Allergology, Faculty of Medicine and Faculty Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic
Park, H.S.;  Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea
Pitsios, C.;  Medical School, University of Cyprus, Nicosia, Cyprus
Plavec, D.;  Srebrnjak Children's Hospital, Zagreb, Croatia, Medical Faculty, University JJ Strossmayer of Osijek, Osijek, Croatia
Popov, T.A.;  Clinic of Occupational Diseases, University Hospital Sveti Ivan Rilski, Sofia, Bulgaria
Puggioni, F.;  Personalized medicine Asthma & Allergy, Rozzano, IRCCS Humanitas Research Center, Milan, Italy
Quirce, S.;  Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain
Recto, M.;  Division of Adult and Pediatric Allergy and Immunology, University of the Philippines- Philippines General Hospital, Manila, Philippines
Repka-Ramirez, M.S.;  Division of Allergy, Asthma and Immunology, Clinics Hospital, San Lorenzo, Paraguay
Robalo Cordeiro, C.;  Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Roche, N.;  Pneumologie, AP-HP Centre, Université de Paris Cité, Hôpital Cochin, Paris, France, UMR 1016, Institut Cochin, Paris, France
Rodriguez-Gonzalez, M.;  Pediatric Allergy and Clinical Immunology, Hospital Espanol de Mexico, Mexico City, Mexico
Romantowski, J.;  Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
Rosario Filho, N.;  Department of Pediatrics, Federal University of Parana, Curitiba, Brazil
Rottem, M.;  Division of Allergy, Asthma and Clinical Immunology, Emek Medical Center, Afula, Israel
Sagara, H.;  Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, Tokyo, Japan
Serpa, F.S.;  Asthma Reference Center - School of Medicine of Santa Casa de Misericórdia of Vitória, Espírito Santo, Brazil
Sayah, Z.;  SMAIC Société Marocaine d’ Allergologie et Immunologie Clinique, Rabat, Morocco
Scheire, S.;  Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
Schmid-Grendelmeier, P.;  Allergy Unit, Department of Dermatology, University Hospital of Zurich, Zürich, Switzerland
Sisul, J.C.;  Allergy & Asthma, Clinica SISUL, FACAAI, SPAAI, Asuncion, Paraguay
Sole, D.;  Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil
Soto-Martinez, M.;  Division of Respiratory Medicine, Department of Pediatrics, Hospital Nacional de Niños, Universidad de Costa Rica, San Jose, Costa Rica
Sova, M.;  Department of Respiratory Medicine and Tuberculosis, University Hospital, Brno, Czech Republic
Sperl, A.;  Center for Rhinology and Allergology, Wiesbaden, Germany
Spranger, O.;  Global Allergy and Airways Patient Platform GAAPP, Vienna, Austria
Stelmach, R.;  Pulmonary Division, Heart Institute (InCor), Hospital da Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
Suppli Ulrik, C.;  Department of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Copenhagen, Denmark, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Thomas, M.;  University of Southampton, Southampton, United Kingdom
To, T.;  The Hospital for Sick Children, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
Todo-Bom, A.;  Imunoalergologia, Centro Hospitalar Universitário de Coimbra, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Tomazic, P.V.;  Department of General ORL, H&NS, Medical University of Graz, ENT-University Hospital Graz, Graz, Austria
Urrutia-Pereira, M.;  Universidade Federal dos Pampa, Uruguaiana, Brazil
Valentin-Rostan, M.;  Allergist, Montevideo, Uruguay
Van Ganse, E.;  Research on Healthcare Performance (RESHAPE), INSERM U1290, Université Claude Bernard Lyon1, Lyon, France
van Hage, M.;  Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden, Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden
Vasankari, T.;  FILHA, Finnish Lung Health Association, Helsinki, Finland, Department of Clinical Medicine, Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland
Vichyanond, P.;  Division of Allergy and Immunology, Department of Pediatrics, Siriraj Hospital, Mahidol University Faculty of Medicine, Bangkok, Thailand
Viegi, G.;  Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Pisa, Italy
Wallace, D.;  College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, United States
Wang, D.Y.;  Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Williams, S.;  International Primary Care Respiratory Group IPCRG, Aberdeen, United Kingdom
Worm, M.;  Division of Allergy and Immunology Department of Dermatology, Allergy and Venerology, Charité Universitätsmedizin Berlin, Berlin, Germany
Yiallouros, P.;  Medical School, University of Cyprus, Nicosia, Cyprus
Yusuf, O.;  The Allergy and Asthma Institute, Islamabad, Pakistan
Zaitoun, F.;  Lebanese-American University, Clemenceau Medical Center DHCC, Dubai, United Arab Emirates
Zernotti, M.;  Universidad Católica de Córdoba, Universidad Nacional de Villa Maria, Villa Maria, Argentina
Zidarn, M.;  University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Zuberbier, J.;  Berlin Institute of Health, Berlin, Germany
Fonseca, J.A.;  MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences
Faculty of Medicine, University of Porto;  Porto, Portugal, CINTESIS@RISE– Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal
Zuberbier, T.;  Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Allergology and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Berlin, Germany
Anto, J.M.;  Universitat Pompeu Fabra (UPF), Barcelona, Spain, ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
More authors (243 more) Less
Language :
English
Title :
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis
Publication date :
2023
Journal title :
Allergy
ISSN :
0105-4538
eISSN :
1398-9995
Publisher :
John Wiley and Sons Inc
Peer reviewed :
Peer Reviewed verified by ORBi
Funding text :
None. Open Access funding enabled and organized by Projekt DEAL.
Available on ORBi :
since 19 May 2023

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