Article (Scientific journals)
Identification by cluster analysis of patients with asthma and nasal symptoms using the MASK-air® mHealth app
Bousquet, J.; Sousa-Pinto, B.; Faculty of Medicine, University of Porto et al.
2022In Pulmonology
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Keywords :
Asthma; Cluster analysis; Control; Rhinitis; Treatment
Abstract :
[en] Background: The self-reporting of asthma frequently leads to patient misidentification in epidemiological studies. Strategies combining the triangulation of data sources may help to improve the identification of people with asthma. We aimed to combine information from the self-reporting of asthma, medication use and symptoms to identify asthma patterns in the users of an mHealth app. Methods: We studied MASK-air® users who reported their daily asthma symptoms (assessed by a 0-100 visual analogue scale – “VAS Asthma”) at least three times (either in three different months or in any period). K-means cluster analysis methods were applied to identify asthma patterns based on: (i) whether the user self-reported asthma; (ii) whether the user reported asthma medication use and (iii) VAS asthma. Clusters were compared by the number of medications used, VAS asthma levels and Control of Asthma and Allergic Rhinitis Test (CARAT) levels. Findings: We assessed a total of 8,075 MASK-air® users. The main clustering approach resulted in the identification of seven groups. These groups were interpreted as probable: (i) severe/uncontrolled asthma despite treatment (11.9-16.1% of MASK-air® users); (ii) treated and partly-controlled asthma (6.3-9.7%); (iii) treated and controlled asthma (4.6-5.5%); (iv) untreated uncontrolled asthma (18.2-20.5%); (v) untreated partly-controlled asthma (10.1-10.7%); (vi) untreated controlled asthma (6.7-8.5%) and (vii) no evidence of asthma (33.0-40.2%). This classification was validated in a study of 192 patients enrolled by physicians. Interpretation: We identified seven profiles based on the probability of having asthma and on its level of control. mHealth tools are hypothesis-generating and complement classical epidemiological approaches in identifying patients with asthma. © 2022 Sociedade Portuguesa de Pneumologia
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Bousquet, J.;  Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany, University Hospital, Montpellier, Montpellier, France
Sousa-Pinto, B.;  MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences
Faculty of Medicine, University of Porto;  Porto, Portugal, CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal, RISE – Health Research Network, University of Porto, Porto, Portugal
Anto, J.M.;  ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Amaral, R.;  MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences
Faculty of Medicine, University of Porto;  Porto, Portugal, CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal, RISE – Health Research Network, University of Porto, Porto, Portugal
Brussino, L.;  Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino & Mauriziano Hospital, Torino, Italy
Canonica, G.W.;  Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy, Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy
Cruz, A.A.;  Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Bahia, Salvador, Brazil
Gemicioglu, B.;  Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey
Haahtela, T.;  Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Finland
Kupczyk, M.;  Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Poland
Kvedariene, V.;  Institute of Clinical medicine, Clinic of Chest diseases and Allergology, Faculty of Medicine, Vilnius University and Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Larenas-Linnemann, D.E.;  Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Pham-Thi, N.;  Ecole Polytechnique Palaiseau, IRBA (Institut de Recherche bio-Médicale des Armées), Bretigny, France
Puggioni, F.;  Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy, Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy
Regateiro, F.S.;  Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, and Coimbra Institute for Clinical and Biomedical Research (ICBR), Faculty of Medicine, University of Coimbra, and Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Romantowski, J.;  Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
Sastre, J.;  Fundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid, Spain
Scichilone, N.;  PROMISE Department, University of Palermo, Palermo, Italy
Taborda-Barata, L.;  Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, and UBIAir - Clinical & Experimental Lung Centre, and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Ventura, M.T.;  Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy
Agache, I.;  Transylvania University Brasov, Brasov, Romania
Bedbrook, A.;  ARIA, Montpellier, France
Bergmann, K.C.;  Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany
Bosnic-Anticevich, S.;  Quality Use of Respiratory Medicine Group, Woolcock Institute of Medical Research, The University of Sydney, and Sydney Local Health District, Sydney, NSW, Australia
Bonini, M.;  Department of Cardiovascular and Thoracic Sciences, Università Cattolica del Sacro Cuore, Rome, Italy, Department of Clinical and Surgical Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy, National Heart and Lung Institute, Royal Brompton Hospital & Imperial College London, United Kingdom
Boulet, L.-P.;  Quebec Heart and Lung Institute, Laval University, Québec City, QC, Canada
Brusselle, G.;  Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
Buhl, R.;  Dept of Pulmonary Medicine, Mainz University Hospital, Mainz, Germany
Cecchi, L.;  SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy
Charpin, D.;  Clinique des bronches, allergie et sommeil, Hôpital Nord, Marseille, France
Chaves-Loureiro, C.;  Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Czarlewski, W.;  Medical Consulting Czarlewski, Levallois, France
de Blay, F.;  Allergy Division, Chest Disease Department, University Hospital of Strasbourg, and Federation of translational medicine, University of Strasbourg, Strasbourg, France
Devillier, P.;  VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France
Joos, G.;  Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
Jutel, M.;  Department of Clinical Immunology, Wrocław Medical University, ALL-MED Medical Research Institute, Wroclaw, Poland
Klimek, L.;  Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Center for Rhinology and Allergology, Wiesbaden, Germany
Kuna, P.;  Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Poland
Laune, D.;  KYomed INNOV, Montpellier, France
Pech, J.L.;  University of Guadalajara, Guadalajara, Mexico
Makela, M.;  Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Finland
Morais-Almeida, M.;  Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal
Nadif, R.;  Université Paris-Saclay, UVSQ, Univ. Paris-Sud, and Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France
Niedoszytko, M.;  Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
Ohta, K.;  National Hospital Organization, Tokyo National Hospital, JATA Fukujuji Hospital, Tokyo, Japan
Papadopoulos, N.G.;  Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Papi, A.;  Respiratory Medicine, Department of Translational Medicine, University of Ferrara, Ferrara, Italy
Yeverino, D.R.;  Allergy and Clinical Immunology Department, Hospital Universitario de Puebla, Puebla, Mexico
Roche, N.;  Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, Paris and UMR 1016, Institut Cochin, Paris, France
Sá-Sousa, A.;  MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences
Faculty of Medicine, University of Porto;  Porto, Portugal, CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal, RISE – Health Research Network, University of Porto, Porto, Portugal
Samolinski, B.;  Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Poland
Shamji, M.H.;  National Heart and Lung Institute, Imperial College London, NIHR Imperial Biomedical Research Centre, London, United Kingdom
Sheikh, A.;  Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom
Suppli Ulrik, C.;  Department of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, and Institute of Cinical Medicine, University of Copenhagen, Denmark
Usmani, O.S.;  National Heart and Lung Institute (NHLI), Imperial College London & Royal Brompton Hospital, Airways Disease Section, London, United Kingdom
Valiulis, A.;  Institute of Clinical Medicine and Institute of Health Sciences,Vilnius, Medical Faculty of Vilnius University, Vilnius, Lithuania
Vandenplas, O.;  Department of Chest Medicine, Centre Hospitalier Universitaire UCL, Namur, Université Catholique de Louvain, Yvoir, Belgium
Yorgancioglu, A.;  Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
Zuberbier, T.;  Institute of Allergology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany
Fonseca, J.A.;  MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences
Faculty of Medicine, University of Porto;  Porto, Portugal, CINTESIS – Center for Health Technology and Services Research, University of Porto, Porto, Portugal, RISE – Health Research Network, University of Porto, Porto, Portugal
More authors (55 more) Less
Language :
English
Title :
Identification by cluster analysis of patients with asthma and nasal symptoms using the MASK-air® mHealth app
Publication date :
2022
Journal title :
Pulmonology
ISSN :
2531-0429
eISSN :
2531-0437
Publisher :
Elsevier Espana S.L.U
Peer reviewed :
Peer Reviewed verified by ORBi
Funding text :
Dr. Papadopoulos reports personal fees from Novartis, personal fees from Nutricia, personal fees from HAL, personal fees from MENARINI/FAES FARMA, personal fees from SANOFI, personal fees from MYLAN/MEDA, personal fees from BIOMAY, personal fees from AstraZeneca, personal fees from GSK, personal fees from MSD, personal fees from ASIT BIOTECH, personal fees from Boehringer Ingelheim, grants from Gerolymatos International SA, grants from Capricare, outside the submitted work.
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