HIIT; MICT; aging; mass spectrometry; metabolomics; obesity; Endocrinology, Diabetes and Metabolism; Biochemistry; Molecular Biology
Abstract :
[en] Physical activity can be effective in preventing some of the adverse effects of aging on health. High-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) are beneficial interventions for the quality of life of obese older individuals. The understanding of all possible metabolic mechanisms underlying these beneficial changes has not yet been established. The aim of this study was to analyze changes in the serum metabolome after 12 weeks of HIIT and MICT in obese older adults. Thirty-eight participants performed either HIIT (n = 26) or MICT (n = 12) three times per week for 12 weeks. Serum metabolites as well as clinical and biological parameters were assessed before and after the 12-week intervention. Among the 364 metabolites and ratio of metabolites identified, 51 metabolites changed significantly following the 12-week intervention. Out of them, 21 significantly changed following HIIT intervention and 18 significantly changed following MICT. Associations with clinical and biological adaptations revealed that changes in acyl-alkyl-phosphatidylcholine (PCae) (22:1) correlated positively with changes in handgrip strength in the HIIT group (r = 0.52, p < 0.01). A negative correlation was also observed between 2-oxoglutaric acid and HOMA-IR (r = -0.44, p < 0.01) when considering both groups together (HIIT and MICT). This metabolite also correlated positively with quantitative insulin-sensitivity check index (QUICKI) in both groups together (r = 0.46, p < 0.01) and the HIIT group (r = 0.51, p < 0.01). Additionally, in the MICT group, fumaric acid was positively correlated with triglyceride levels (r = 0.73, p < 0.01) and acetylcarnitine correlated positively with low-density lipoprotein (LDL) cholesterol (r = 0.81, p < 0.01). These four metabolites might represent potential metabolites of interest concerning muscle strength, glycemic parameters, as well as lipid profile parameters, and hence, for a potential healthy aging. Future studies are needed to confirm the association between these metabolites and a healthy aging.
Disciplines :
Geriatrics
Author, co-author :
Youssef, Layale ; School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, Montreal, QC H3T 1J4, Canada ; Research Center of the Montreal Geriatrics Institute (CRIUGM), Montreal, QC H3W 1W5, Canada
Bourgin, Mélanie ; INSERM U1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, 75006 Paris, France ; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, AMMICa US23/CNRS UMS3655, 94805 Villejuif, France
Durand, Sylvère; INSERM U1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, 75006 Paris, France ; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, AMMICa US23/CNRS UMS3655, 94805 Villejuif, France
Aprahamian, Fanny; INSERM U1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, 75006 Paris, France ; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, AMMICa US23/CNRS UMS3655, 94805 Villejuif, France
Lefevre, Deborah; INSERM U1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, 75006 Paris, France ; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, AMMICa US23/CNRS UMS3655, 94805 Villejuif, France
Maiuri, Maria Chiara; INSERM U1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, 75006 Paris, France ; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, AMMICa US23/CNRS UMS3655, 94805 Villejuif, France
Marcangeli, Vincent; Département des Sciences Biologiques, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada ; Département des Sciences de l'Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada
Dulac, Maude; Département des Sciences Biologiques, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada ; Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada
Hajj-Boutros, Guy; Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada
Buckinx, Fanny ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; Research Center of the Montreal Geriatrics Institute (CRIUGM), Montreal, QC H3W 1W5, Canada ; Département des Sciences de l'Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada
Peyrusqué, Eva; Research Center of the Montreal Geriatrics Institute (CRIUGM), Montreal, QC H3W 1W5, Canada ; Département des Sciences de l'Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada ; Groupe de Recherche en Activité Physique Adaptée, Montreal, QC H2X 1Y4, Canada
Gaudreau, Pierrette; Département de Médecine de l'Université de Montréal, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC H2X 3E4, Canada
Morais, José A; Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada
Gouspillou, Gilles ; Research Center of the Montreal Geriatrics Institute (CRIUGM), Montreal, QC H3W 1W5, Canada ; Département des Sciences de l'Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada ; Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada ; Groupe de Recherche en Activité Physique Adaptée, Montreal, QC H2X 1Y4, Canada
Kroemer, Guido ; INSERM U1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, 75006 Paris, France ; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, AMMICa US23/CNRS UMS3655, 94805 Villejuif, France
Aubertin-Leheudre, Mylène; School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, Montreal, QC H3T 1J4, Canada ; Research Center of the Montreal Geriatrics Institute (CRIUGM), Montreal, QC H3W 1W5, Canada ; Département des Sciences de l'Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada ; Groupe de Recherche en Activité Physique Adaptée, Montreal, QC H2X 1Y4, Canada
Noirez, Philippe ; Département des Sciences de l'Activité Physique, Faculté des Sciences, Université du Québec à Montréal, Montreal, QC H2X 1Y4, Canada ; Performance, Santé, Métrologie, Société (PSMS), UFR STAPS, Université de Reims Champagne Ardenne, 51100 Reims, France ; T3S, Inserm, Université Paris Cité, 75006 Paris, France ; Institut de Recherche Médicale et d'Épidémiologie du Sport (IRMES), Institut National du Sport, de l'Expertise et de la Performance (INSEP), Université Paris Cité, 75012 Paris, France
FRQS - Fonds de Recherche du Québec - Santé UQAM - Université du Québec à Montréal ANR - Agence Nationale de la Recherche ARC - Association pour la Recherche sur le Cancer Cancéropôle Ile-de-France FRM - Fondation pour la Recherche Médicale EU - European Union INCa - Institut National du Cancer INSERM - Institut National de la Santé et de la Recherche Médicale IUF - Institut Universitaire de France Leducq Foundation
Funding text :
This study was supported by grants from the Québec Network for Research on Aging of the Fonds de Recherche en Santé du Québec (FRQS) awarded to M.A.-L., G.G., P.G., J.M., P.N. and by UQAM-FRQS funds awarded to M.A.-L. M.A.-L. is supported by a Chercheur Boursier Senior salary award from the FRQS. G.G. is supported by a Chercheur Boursier Junior 2 salary award from the FRQS. F.B. is supported by a postdoctoral award from the FRQS. M.D. is supported by a PhD award from the FRQS. G.K. is supported by the Ligue contre le Cancer (équipe labellisée); Agence National de la Recherche (ANR)—Projets blancs; AMMICa US23/CNRS UMS3655; Association pour la recherche sur le cancer (ARC); Association “Ruban Rose”; Cancéropôle Ile-de-France; Fondation pour la Recherche Médicale (FRM); a donation by Elior; Equipex Onco-Pheno-Screen; European Joint Programme on Rare Diseases (EJPRD); Gustave Roussy Odyssea, the European Union Horizon 2020 Projects Oncobiome and Crimson; Fondation Carrefour; Institut National du Cancer (INCa); Inserm (HTE); Institut Universitaire de France; LabEx Immuno-Oncology (ANR-18-IDEX-0001); the Leducq Foundation; a Cancer Research ASPIRE Award from the Mark Foundation; the RHU Torino Lumière; Seerave Foundation; SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); and SIRIC Cancer Research and Personalized Medicine (CARPEM). This study contributes to the IdEx Université de Paris ANR-18-IDEX-0001.
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