Connectivity; Entropy; Fractional anisotropy; Graph-theory; Negative symptoms; Schizophrenia; Adult; Anisotropy; Diffusion Tensor Imaging; Electroencephalography; Female; Humans; Image Processing, Computer-Assisted; Male; Neural Pathways/diagnostic imaging; Predictive Value of Tests; Principal Component Analysis; Schizophrenia/diagnostic imaging; Schizophrenia/physiopathology; Theta Rhythm/physiology; Young Adult; Neural Pathways; Theta Rhythm; Radiology, Nuclear Medicine and Imaging; Neurology; Neurology (clinical); Cognitive Neuroscience
Abstract :
[en] Spectral entropy (SE) allows comparing task-related modulation of electroencephalogram (EEG) between patients and controls, i.e. spectral changes of the EEG associated to task performance. A SE modulation deficit has been replicated in different schizophrenia samples. To investigate the underpinnings of SE modulation deficits in schizophrenia, we applied graph-theory to EEG recordings during a P300 task and fractional anisotropy (FA) data from diffusion tensor imaging in 48 patients (23 first episodes) and 87 healthy controls. Functional connectivity was assessed from phase-locking values among sensors in the theta band, and structural connectivity was based on FA values for the tracts connecting pairs of regions. From those data, averaged clustering coefficient (CLC), characteristic path-length (PL) and connectivity strength (CS, also known as density) were calculated for both functional and structural networks. The corresponding functional modulation values were calculated as the difference in SE and CLC, PL and CS between the pre-stimulus and response windows during the task. The results revealed a higher functional CS in the pre-stimulus window in patients, predictive of smaller modulation of SE in this group. The amount of increase in theta CS from pre-stimulus to response related to SE modulation in patients and controls. Structural CLC was associated with SE modulation in the patients. SE modulation was predictive of negative symptoms, whereas CLC and PL modulation was associated with cognitive performance in the patients. These results support that a hyperactive functional connectivity and/or structural connective deficits in the patients hamper the dynamical modulation of connectivity underlying cognition.
Disciplines :
Neurology
Author, co-author :
Gomez-Pilar, Javier; Biomedical Engineering Group, University of Valladolid, Paseo de Belén, 15, 47011 Valladolid, Spain
de Luis-García, Rodrigo; Imaging Processing Laboratory, University of Valladolid, Paseo de Belén, 15, 47011 Valladolid, Spain
Lubeiro, Alba; Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005 Valladolid, Spain
de Uribe, Nieves; Psychiatry Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain
Poza, Jesús; Biomedical Engineering Group, University of Valladolid, Paseo de Belén, 15, 47011 Valladolid, Spain, Neurosciences Institute of Castilla y León (INCYL), Pintor Fernando Gallego, 1, 37007, University of Salamanca, Spain, IMUVA, Mathematics Research Institute, University of Valladolid, Valladolid, Spain
Nunez Novo, Pablo ; University of Valladolid > Biomedical Engineering Group
Ayuso, Marta; Neurophysiology Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain
Hornero, Roberto; Biomedical Engineering Group, University of Valladolid, Paseo de Belén, 15, 47011 Valladolid, Spain, Neurosciences Institute of Castilla y León (INCYL), Pintor Fernando Gallego, 1, 37007, University of Salamanca, Spain, IMUVA, Mathematics Research Institute, University of Valladolid, Valladolid, Spain
Molina, Vicente ; Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005 Valladolid, Spain, Psychiatry Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain., Neurosciences Institute of Castilla y León (INCYL), Pintor Fernando Gallego, 1, 37007, University of Salamanca, Spain. Electronic address: vicente.molina@uva.es
Language :
English
Title :
Deficits of entropy modulation in schizophrenia are predicted by functional connectivity strength in the theta band and structural clustering.
ISCIII - Instituto de Salud Carlos III [ES] JCYL - Junta de Castilla y León [ES] MINECO - Gobierno de Espana. Ministerio de Economia y Competitividad [ES] FEDER - Fonds Européen de Développement Régional [BE] UVA - University of Valladolid [ES]
Funding text :
This research project was supported in part by grants from Instituto de Salud Carlos III under project PI15/00299, Consejería de Educacion de Castilla y Leon project VA057P17, “Gerencia Regional de Salud de Castilla y León” under projects GRS 1263/A/16 and GRS 1485/A/17, and “Ministerio de Economía y Competitividad” and FEDER under grants TEC2014-53196-R and TEC2013-44194-P; by ‘European Commission’ and FEDER under project ‘Análisis y correlación entre el genoma completo y la actividad cerebral para la ayuda en el diagnóstico de la enfermedad de Alzheimer’ (’Cooperation Programme Interreg V-A Spain-Portugal POCTEP 2014-2020’). J. Gomez-Pilar was in receipt of a grant from University of Valladolid and A. Lubeiro was in receipt of a grant from Consejería de Educación de la Junta de Castilla y León.This research project was supported in part by grants from Instituto de Salud Carlos III under project PI15/00299 , Consejería de Educacion de Castilla y Leon project VA057P17 , “ Gerencia Regional de Salud de Castilla y León ” under projects GRS 1263/A/16 and GRS 1485/A/17 , and “ Ministerio de Economía y Competitividad ” and FEDER under grants TEC2014-53196-R and TEC2013-44194-P ; by ‘European Commission’ and FEDER under project 'Análisis y correlación entre el genoma completo y la actividad cerebral para la ayuda en el diagnóstico de la enfermedad de Alzheimer' ('Cooperation Programme Interreg V-A Spain-Portugal POCTEP 2014-2020'). J. Gomez-Pilar was in receipt of a grant from University of Valladolid and A. Lubeiro was in receipt of a grant from Consejería de Educación de la Junta de Castilla y León .
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