Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder.

Bipolar disorder; Connectivity strength; Functional network; Graph-theory; Schizophrenia; Antipsychotic Agents; Adult; Antipsychotic Agents/therapeutic use; Bipolar Disorder/physiopathology; Bipolar Disorder/psychology; Cognition; Event-Related Potentials, P300; Female; Humans; Male; Middle Aged; Nerve Net/physiopathology; Neural Pathways/physiopathology; Schizophrenia/physiopathology; Schizophrenic Psychology; Theta Rhythm; Treatment Outcome; Young Adult; Electroencephalography; Nerve Net; Neural Pathways; Pharmacology; Biological Psychiatry

Abstract :

[en] The application of graph theory measures in the study of functional brain networks allows for the description of their general properties and their alterations in mental illness. Among these measures, connectivity strength (CS) estimates the degree of functional connectivity of the whole network. Previous studies in schizophrenia patients have reported higher baseline CS values and modulation deficits in EEG spectral properties during cognitive activity. The specificity of these alterations and their relationships with pharmacological treatments remain unknown. Therefore, in the present study, we assessed functional CS on EEG-based brain networks in 79 schizophrenia and 29 bipolar patients in addition to 63 healthy controls. The subjects performed a P300 task during the EEG recordings from which the pre-stimulus and the task-related modulation CS values were computed in the global and theta bands. These values were compared between the groups and between the patients who had and had not received different treatments. The global band pre-stimulus CS was significantly higher in the schizophrenia group compared with the bipolar and control groups. Theta band CS modulation was decreased in schizophrenia and bipolar patients. Treatment with antipsychotics, lithium, benzodiazepines, and anticonvulsants did not significantly alter these CS values. The first-episode and chronic schizophrenia patients did not show significant differences in CS values. Higher global band pre-stimulus CS values were associated with worse general cognition in schizophrenia patients. These data support increased connectivity in the whole-brain network that is specific to schizophrenia and suggest a general hyper-synchronized basal state that might hamper cognition in this syndrome.

Disciplines :

Psychiatry

Author, co-author :

Cea-Cañas, Benjamín; Clinical Neurophysiology Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain

Gomez-Pilar, Javier; Biomedical Engineering Group, University of Valladolid, Paseo de Belén, 15, 47011 Valladolid, Spain

Nunez Novo, Pablo ; University of Valladolid > Biomedical Engineering Group

Rodríguez-Vázquez, Eva; Psychiatry Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain

de Uribe, Nieves; Psychiatry Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain

Díez, Álvaro; Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005 Valladolid, Spain

Pérez-Escudero, Adela; Psychiatry Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain

Molina, Vicente; Psychiatry Service, Clinical Hospital of Valladolid, Ramón y Cajal, 3, 47003 Valladolid, Spain, Psychiatry Department, School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005 Valladolid, Spain, Neurosciences Institute of Castilla y León (INCYL), School of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005 Valladolid, Spain. Electronic address: vicente.molina@uva.es

Language :

English

Title :

Connectivity strength of the EEG functional network in schizophrenia and bipolar disorder.

Publication date :

02 March 2020

Journal title :

Progress in Neuro-Psychopharmacology and Biological Psychiatry

ISSN :

0278-5846

eISSN :

1878-4216

Publisher :

Elsevier Inc., England

Volume :

Pages :

109801

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0278584619304725?httpAccept=text/xml

Funders :

ISCIII - Instituto de Salud Carlos III [ES]
JCYL - Junta de Castilla y León [ES]

Funding text :

This work has been supported by the following grants: the “ Instituto de Salud Carlos III ” ( PI15/00299 and PI18/00178 ), the “Gerencia Regional de Salud de Castilla y León” ( GRS 1485/A/17 and GRS 1721/A/18 ), and the “ Consejería de Educación de la Junta de Castilla y León ” ( VA059U13 and VA057P17 ). P. Núñez was in receipt of a predoctoral scholarship ‘Ayuda para contratos predoctorales para la Formación de Profesorado Universitario (FPU)’ grant from the ‘ Ministerio de Educación, Cultura y Deporte ’ ( FPU17/00850 ).

Available on ORBi :

since 17 May 2023

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