Overview on microfluidics devices for monitoring brain disorder biomarkers

Nix, Cindy; Ghassemi, Maryam; Crommen, Jacques; Fillet, Marianne

doi:10.1016/j.trac.2022.116693

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Overview on microfluidics devices for monitoring brain disorder biomarkers

Nix, Cindy; Ghassemi, Maryam; Crommen, Jacques et al.

2022 • In TrAC: Trends in Analytical Chemistry, 155, p. 116693

Peer Reviewed verified by ORBi

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10.1016/j.trac.2022.116693

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Keywords :

Biomarker detection; Neurological disorder; Organ-on-a-chip; Brain disorders; Microfluidics devices

Abstract :

[en] Neurological disorders are one of the leading causes of disability and death worldwide. The complexity of the human brain and therefore the significant structural gap between animal models and humans, all serve to hinder translational success. Recent advances in microfluidic devices and human organ-on-a-chip systems have provided new opportunities to study and monitor such diseases with the benefits of precise control, lower sample requirement and reagent consumption, cost-effectiveness and high throughput screening. Combined with biosensors, mass spectrometry or automatic imaging systems, they have emerged as a unique way to facilitate personalized medicine. To obtain relevant and reliable information, it is crucial to address the different challenges specific to each type of microfluidics device. In the following review, the discussion is focused on the technical setup of microfluidic devices for the detection of brain disorder biomarkers and on the microfluidics strategies that are applied to monitor neurological diseases. In the last section, we also discuss limitations, challenges and regulatory requirements that remain to be considered in future experiments.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Nix, Cindy ^✱; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Ghassemi, Maryam ^✱; University of Liège (ULiège), CIRM, Laboratory for the Analysis of Medicines, Liège, Belgium

Crommen, Jacques ; Université de Liège - ULiège > Département de pharmacie

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Overview on microfluidics devices for monitoring brain disorder biomarkers

Publication date :

October 2022

Journal title :

TrAC: Trends in Analytical Chemistry

ISSN :

0165-9936

eISSN :

1879-3142

Publisher :

Elsevier B.V.

Volume :

155

Pages :

116693

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0165993622001765?httpAccept=text/xml

Funders :

FEDER - Fonds Européen de Développement Régional [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]

Funding text :

The authors want to thank the National Fund for Scientific Research (F. N. R. S.) for its financial support. Walloon Region of Belgium and EU Commission (project FEDER-PHARE) and FNRS through Chimic EOS project are also acknowledge.

Available on ORBi :

since 08 May 2023

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