Nanomaterials-based Biosensors against Aspergillus and 2 Aspergillosis：Control and Diagnostic Perspectives

Aspergillosis is the name given to the spectrum of diseases caused by the genus
Aspergillus. Research on aspergillosis has shown a progressive expansion over the past
decades, largely due to the rise in the number of immunocompromised individuals who
are at risk for the infection. Nanotechnology provides innovative tools in the medicine,
diagnosis and treatment. The unique properties of nanomaterials like small size in the
nanoscale have attracted researchers to explore their potential, especially in medical
diagnostics. Aptamers, considered as chemical antibody, are short, single-stranded
oligonucleotide molecules with high affinity and specificity to interact with target
molecules even superior to antibody. Accordingly, development of nanomaterials-based
biosensors technology such as immunosensors and aptasensors against Aspergillus and
Aspergillosis is of great significance and urgency. In this book chapter, we
comprehensively introduce and analyze the recent progress of nanomaterials-based
biosensors against Aspergillus and Aspergillosis. In addition, we reveal the challenges
and provide our opinion in future opportunities for such sensing platform development.
Ultimately, conclusion and future prospects are highlighted and summarized.