[en] Three new oleanolic glycosides (1–3), along with seven known saponins from various plants (4–10) were isolated for the first time from the leaves of Aralia nudicaulis. Their structures were elucidated on the basis of spectroscopic evidence, including 1D and 2D NMR, and HRESIMS. Nudicauloside A and B (1–2) have shown moderate anti-inflammatory activity, as demonstrated by inhibition of LPS-induced NO production in raw 264.7 murine macrophages (IC50 = 74–101 μM).
Disciplines :
Chemistry
Author, co-author :
Lavoie, Serge ; Centre de recherche sur la boréalie (CREB), Laboratoire d'analyse et de séparation des essences végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada
Pierra, Julie ; Centre de recherche sur la boréalie (CREB), Laboratoire d'analyse et de séparation des essences végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada
Legault, Jean; Centre de recherche sur la boréalie (CREB), Laboratoire d'analyse et de séparation des essences végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada
Raminoson, Diamondra ; Centre de recherche sur la boréalie (CREB), Laboratoire d'analyse et de séparation des essences végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada
Lion, Quentin ; Université de Liège - ULiège > GIGA > GIGA Stem Cells - Medical Chemistry ; Centre de recherche sur la boréalie (CREB), Laboratoire d'analyse et de séparation des essences végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada
Mshvildadze, Vakhtang; Centre de recherche sur la boréalie (CREB), Laboratoire d'analyse et de séparation des essences végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada
Pichette, André ; Centre de recherche sur la boréalie (CREB), Laboratoire d'analyse et de séparation des essences végétales (LASEVE), Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Canada
Language :
English
Title :
Isolation and characterization of triterpenoid saponins from leaves of Aralia nudicaulis L
The authors thank Mr. Patrick Nadeau for plant identification. Also, Julia Kubanek and Les Gelbaum (Georgia Institute of Technology) are kindly acknowledged for the high-field NMR spectroscopy experiments. Finally, we thank Karl Girard-Lalancette and Audrey Bélanger for the pharmacological assays.
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