[en] Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders. Video abstract.
Disciplines :
Microbiology
Author, co-author :
Han, Hui ; Université de Liège - ULiège > TERRA Research Centre ; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
Yi, Bao; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
Zhong, Ruqing; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
Wang, Mengyu; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
Zhang, Shunfen; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
Ma, Jie; College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China
Yin, Yulong; College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China ; Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125, China
Yin, Jie; College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China. yinjie2014@126.com
Chen, Liang; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. chenliang01@caas.cn
Zhang, Hongfu; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. zhanghongfu@caas.cn ; College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China. zhanghongfu@caas.cn
Language :
English
Title :
From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators.
NSCF - National Natural Science Foundation of China [CN]
Funding text :
The authors acknowledge the financial support from the National Natural Science Foundation (31702119, 31672428), Agricultural Science and Technology Innovation Program (CAAS-ZDRW202006-02, ASTIP-IAS07), and Central Public-interest Scientific Institution Basal Research Fund (Y2021GH01-4) in China.
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