[en] [en] BACKGROUND: The relationships among gastric lymphoid follicular hyperplasia (GLFH), Helicobacter-like organisms (HLOs), and clinical signs have not been established in dogs.
OBJECTIVES: To evaluate the epidemiologic, clinical, endoscopic, and histopathologic findings associated with GLFH in dogs, and determine the association of GLFH with HLOs and the French Bulldog (FB) breed.
ANIMALS: Two hundred eighty-eight dogs that underwent gastroscopy between 2013 and 2016.
METHODS: Retrospective, cross-sectional study. Gastric biopsy samples were reviewed and scored for inflammation and HLOs. Dogs were divided into 3 groups: group 1 (63 FBs), group 2 (45 non-FB brachycephalic dogs), and group 3 (180 nonbrachycephalic dogs). Variables were evaluated for their association with GLFH.
RESULTS: Univariate analysis determined that intact males, young age, vomiting, gastroscopic findings (discoloration, hemorrhage, and ulcers), and histopathologic findings (gastric lamina propria lymphocytic infiltration and HLO score) were associated with GLFH (P ≤ .03). In the multivariate analysis, GLFH was associated with the HLO score (odds ratio [OR] > 5 for HLO scores 1-2 and >15 for HLO score of 3; P < .001), with vomiting (OR > 4; P = .01) but not with FB breed (P = .76) and age (P = .1). The HLO score was associated with younger age (P < .001).
CONCLUSION AND CLINICAL IMPORTANCE: The HLO score was associated with a high GLFH score. Vomiting was associated with GLFH. Helicobacter-like organisms are highly prevalent in young dogs and GLFH is indirectly associated with this factor. Clinical relevance of the identification of GLFH and HLO remains to be determined.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Biénès, Tom ; Centre Hospitalier Vétérinaire Fregis, Arcueil, France ; Department of Clinical Sciences, Faculty of Veterinary Medicine, FARAH, University of Liège, Liège, Belgium
Leal, Rodolfo Oliveira ; Centre Hospitalier Vétérinaire Fregis, Arcueil, France ; CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal ; Hospital Escolar Veterinário-Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal
Domínguez-Ruiz, Marina; Centre Hospitalier Vétérinaire Fregis, Arcueil, France ; Hospital Clínico Veterinario de la Universidad Alfonso X el Sabio, Universidad Alfonso X el Sabio, Madrid, Spain
De Carvalho, Rodolfo Elvas; Centre Hospitalier Vétérinaire Fregis, Arcueil, France
Fernandes Rodrigues, Nina ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH) > FARAH: Médecine vétérinaire comparée
Dally, Claire; LAPVSO Laboratory, Toulouse, France
Husson, Jean-Charles; LAPVSO Laboratory, Toulouse, France
Le Boedec, Kevin ; Centre Hospitalier Vétérinaire Fregis, Arcueil, France
Hernandez, Juan ; Centre Hospitalier Vétérinaire Fregis, Arcueil, France ; Oniris, Department of Clinical Sciences, Nantes-Atlantic College of Veterinary Medicine and Food Sciences, Nantes, France
Language :
English
Title :
Association of gastric lymphofollicular hyperplasia with Helicobacter-like organisms in dogs.
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