Double-Blind Method; Humans; Lactobacillus; Peri-Implantitis; Pilot Projects; Probiotics; Lactobacilli reuteri; debridement; dental plaque; gingival bleeding on probing; peri-implantitis; probiotics; therapy
Abstract :
[en] OBJECTIVES: Examine the clinical and microbiological benefits of a dual-strain Lactobacillus reuteri probiotic on the non-surgical therapy of initial peri-implantitis. MATERIALS AND METHODS: This randomized, double-blind study targeted patients with initial peri-implantitis, that is peri-implantitis with a maximum mean probing pocket depth of 6 mm and maximum 3 mm bone loss compared with loading. A full-mouth prophylaxis was performed and the peri-implantitis sites were debrided. Subsequently, local application of the study drops was carried out at the peri-implantitis sites and the study lozenges were handed out. The patients in the probiotic group received drops and lozenges containing L. reuteri (ATCC PTA 5289 & DSM 17938), those in the control group received placebo products. At the implant level the measurements of interest were bleeding, probing pocket depth and plaque. Full-mouth bleeding and plaque scores were also recorded. Microbiological samples were taken from the tongue, saliva and subgingivally around the implants. RESULTS: All clinical parameters were significantly decreased after 12 and 24 weeks. At the implant level the only statistically significant difference was a greater decrease in plaque levels in the probiotic versus the control group (p = .002 at 24 weeks). At the full-mouth level, the only intergroup difference was the greater decrease in full-mouth bleeding on probing sites in the probiotic group compared with the control group (p < .001 at 24 weeks). Concerning the microbiological outcomes, no significant differences could be found at any time point, neither intra- nor intergroup. CONCLUSIONS: No adjunctive effects of the use of L. reuteri probiotics in the treatment of peri-implantitis were found.
Research center :
d‐BRU - Dental Biomaterials Research Unit - ULiège [BE]
Disciplines :
Dentistry & oral medicine
Author, co-author :
Laleman, Isabelle ; Centre Hospitalier Universitaire de Liège - CHU > > Service de parodontologie, chirurgie bucco-dentaire et chirurgie implantaire ; Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals
Pauwels, Martine; Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals
Quirynen, Marc; Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals
Teughels, Wim; Department of Oral Health Sciences, KU Leuven & Dentistry, University Hospitals
Language :
English
Title :
The usage of a lactobacilli probiotic in the non-surgical therapy of peri-implantitis: A randomized pilot study.
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