MASK-air; asthma; digital; mHealth; rhinitis; Immunology and Allergy; Immunology; Pulmonary and Respiratory Medicine
Abstract :
[en] MASK-air® , a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air® is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK-air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as-needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom-medication score (ARIA-EAACI-CSMS) has been validated for clinical practice and trials. The implications of the novel MASK-air® results should lead to change management in rhinitis and asthma.
Disciplines :
Public health, health care sciences & services
Author, co-author :
Bousquet, Jean ; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany ; University Hospital Montpellier, Montpellier, France ; Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France
Anto, Josep M; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain ; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain ; Universitat Pompeu Fabra (UPF), Barcelona, Spain ; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Sousa-Pinto, Bernardo; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal ; RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Czarlewski, Wienczyslawa; Medical Consulting Czarlewski, Levallois, France ; MASK-air, Montpellier, France
Bedbrook, Anna; MASK-air, Montpellier, France
Haahtela, Tari; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Klimek, Ludger; Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany ; Center for Rhinology and Allergology, Wiesbaden, Germany
Pfaar, Oliver ; Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany
Kuna, Piotr; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Kupczyk, Maciej; Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
Regateiro, Frederico S; Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal ; ICBR, Coimbra Institute for Clinical and Biomedical Research, CIBB, Faculty of Medicine, University of Coimbra, Coimbra, Portugal ; Institute of Immunology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Samolinski, Boleslaw; Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland
Valiulis, Arunas; Institute of Clinical Medicine and Institute of Health Sciences, Vilnius, Lithuania ; Medical Faculty of Vilnius University, Vilnius, Lithuania
Yorgancioglu, Arzu; Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey
Arnavielhe, Sylvie; GRADeS Occitanie, Toulouse, France
Basagaña, Xavier; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain ; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain ; Universitat Pompeu Fabra (UPF), Barcelona, Spain ; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
Bergmann, Karl C; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany
Bosnic-Anticevich, Sinthia; Quality Use of Respiratory Medicine Group, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia ; Sydney Local Health District, Sydney, NSW, Australia
Brussino, Luisa; Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino, Torino, Italy ; Mauriziano Hospital, Torino, Italy
Canonica, G Walter; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy ; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy
Cardona, Victoria ; Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain ; ARADyAL Research Network, Barcelona, Spain
Cecchi, Lorenzo; SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy
Chaves-Loureiro, Claudia; Pneumology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
Costa, Elisio; UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing, University of Porto (Porto4Ageing), Porto, Portugal
Cruz, Alvaro A; Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Bahia, Brazil
Gemicioglu, Bilun; Cerrahpasa Faculty of Medicine, Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Istanbul, Turkey
Fokkens, Wytske J; Department of Otorhinolaryngology, Amsterdam University Medical Centres, location AMC, Amsterdam, the Netherlands
Ivancevich, Juan Carlos; Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina
Kraxner, Helga; Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary
Kvedariene, Violeta; Faculty of Medicine, Institute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Vilnius University, Vilnius, Lithuania ; Faculty of Medicine, Department of Pathology, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania
Larenas-Linnemann, Désirée E; Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico
Laune, Daniel; KYomed INNOV, Montpellier, France
Louis, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie
Makris, Michael; Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece
Maurer, Marcus; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany
Melén, Erik; Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden ; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
Micheli, Yann; KYomed INNOV, Montpellier, France
Morais-Almeida, Mario; Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal
Mullol, Joaquim ; Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Barcelona, Spain ; Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain
Niedoszytko, Marek; Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
Okamoto, Yoshitaka; Chiba University Hospital, Chiba, Japan ; Chiba Rosai Hospital, Chiba, Japan
Papadopoulos, Nikolaos G; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
Patella, Vincenzo; Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Battipaglia, Salerno, Italy ; Agency of Health ASL, Salerno, Italy
Pham-Thi, Nhân; Ecole Polytechnique Palaiseau, IRBA (Institut de Recherche Bio-Médicale des Armées), Bretigny, France
Rouadi, Philip W; Department of Otolaryngology, Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon ; Department of Otorhinolaryngology, Head and Neck Surgery, Dar Al Shifa Hospital, Salmiya, Kuwait
Sastre, Joaquin; Fundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid, Madrid, Spain
Scichilone, Nicola; PROMISE Department, University of Palermo, Palermo, Italy
Sheikh, Aziz; Usher Institute, The University of Edinburgh, Edinburgh, UK
Sofiev, Mikhail; Finnish Meteorological Institute (FMI), Helsinki, Finland
Taborda-Barata, Luis; Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal ; UBIAir - Clinical & Experimental Lung Centre and CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Toppila-Salmi, Sanna ; Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland
Tsiligianni, Ioanna; International Primary Care Respiratory Group IPCRG, Aberdeen, Scotland ; Health Planning Unit, Faculty of Medicine, Department of Social Medicine, University of Crete, Crete, Greece
Valovirta, Erkka; Department of Lung Diseases and Clinical Immunology, University of Turku, Turku, Finland ; Terveystalo Allergy Clinic, Turku, Finland
Ventura, Maria Teresa ; Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy
Vieira, Rafael José; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal ; RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Zidarn, Mihaela ; University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia ; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Amaral, Rita; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal ; RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Ansotegui, Ignacio J; Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain
Bédard, Annabelle; Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France ; Université Paris-Saclay, UVSQ, University Paris-Sud, Villejuif, France
Benveniste, Samuel; National Center of Expertise in Cognitive Stimulation (CEN STIMCO), Broca Hospital, Paris, France ; Mines ParisTech CRI - PSL Research University, Fontainebleau, France
Bewick, Michael; University of Central Lancashire Medical School, Preston, UK
Bindslev-Jensen, Carsten ; Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark ; Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Finland
Blain, Hubert ; Department of Geriatrics, Montpellier University Hospital, MUSE, Montpellier, France
Bonini, Matteo; Department of Clinical and Surgical Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy ; National Heart and Lung Institute, Royal Brompton Hospital & Imperial College London, London, UK
Bourret, Rodolphe; Centre Hospitalier Valenciennes, Valenciennes, France
Braido, Fulvio; Department of Internal Medicine (DiMI), University of Genoa, Genova, Italy ; IRCCS Ospedale Policlinico San Martino, Genova, Italy
Carreiro-Martins, Pedro; NOVA Medical School/Comprehensive Health Research Centre (CHRC), Lisbon, Portugal ; Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal
Charpin, Denis; Clinique des Bronches, Allergie et Sommeil, Hôpital Nord, Marseille, France
Cherrez-Ojeda, Ivan ; Universidad Espíritu Santo, Samborondón, Ecuador ; Respiralab Research Group, Guayaquil, Guayas, Ecuador
Chivato, Tomas; School of Medicine, University CEU San Pablo, Madrid, Spain
Chu, Derek K; Department of Health Research Methods, Evidence, and Impact & Department of Medicine, McMaster University, Hamilton, ON, Canada
Cingi, Cemal ; Medical Faculty, ENT Department, Eskisehir Osmangazi University, Eskisehir, Turkey
Del Giacco, Stefano; Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy
de Blay, Frédéric; Allergy Division, Chest Disease Department, University Hospital of Strasbourg, Strasbourg, France ; Federation of Translational Medicine, University of Strasbourg, Strasbourg, France
Devillier, Philippe; VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France
De Vries, Govert; Peercode BV, Geldermalsen, The Netherlands
Doulaptsi, Maria; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Crete, Heraklion, Crete, Greece
Doyen, Virginie; Department of Chest Medicine, Centre Hospitalier Universitaire UCL Namur, Namur, Belgique ; Université Catholique de Louvain, Yvoir, Belgium
Dray, Gérard; Ecole des Mines, Alès, France
Fontaine, Jean-François; Allergist, Reims, France
Gomez, R Maximiliano; School of Health Sciences, Catholic University of Salta, Salta, Argentina
Hagemann, Jan; Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany ; Center for Rhinology and Allergology, Wiesbaden, Germany
Heffler, Enrico; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy ; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy
Hofmann, Maja ; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Berlin Institute of Health, Berlin, Germany
Jassem, Ewa; Department of Pneumology, Medical University of Gdańsk, Gdańsk, Poland
Jutel, Marek; Department of Clinical Immunology, Wrocław Medical University, Wrocław, Poland ; ALL-MED Medical Research Institute, Wroclaw, Poland
Keil, Thomas; Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany ; Institute for Clinical Epidemiology and Biometry, University of Wuerzburg, Wuerzburg, Germany ; State Institute of Health, Bavarian Health and Food Safety Authority, Erlangen, Germany
Kritikos, Vicky; Quality Use of Respiratory Medicine Group, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia
Kull, Inger; Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden ; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
Kulus, Marek; Department of Pediatric Respiratory Diseases and Allergology, Medical University of Warsaw, Warsaw, Poland
Lourenço, Olga; Faculty of Health Sciences and CICS - UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
Mathieu-Dupas, Eve; KYomed INNOV, Montpellier, France
Menditto, Enrica; CIRFF, Department of Pharmacy, University of Naples Federico II, Naples, Italy
Mösges, Ralph ; CRI-Clinical Research International-Ltd, Hamburg, Germany
Murray, Ruth; Medical Communication Consultant, Medscript Ltd, Dundalk, Ireland and Wellington, New Zealand ; Research Fellow, OPC, Cambridge, UK
Nadif, Rachel; Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France ; Université Paris-Saclay, UVSQ, University Paris-Sud, Villejuif, France
Neffen, Hugo; Center of Allergy, Immunology and Respiratory Diseases, Santa Fe, Argentina
Nicola, Stefania; Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino, Torino, Italy
O'Hehir, Robyn; Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia
Olze, Heidi; Berlin Institute of Health, Berlin, Germany ; Department of Otorhinolaryngology, Charité-Universitätsmedizin Berlin, Berlin, Germany
Palamarchuk, Yuliia; Finnish Meteorological Institute (FMI), Helsinki, Finland
Pépin, Jean-Louis; Université Grenoble Alpes, Laboratoire HP2, Grenoble, France ; INSERM, U1042, Villejuif, France
Pétré, Benoît ; Université de Liège - ULiège > Département des sciences de la santé publique > Education thérapeutique du patient au service des soins intégrés
Picard, Robert; Conseil Général de l'Economie Ministère de l'Economie, de l'Industrie et du Numérique, Paris, France
Pitsios, Constantinos; Medical School, University of Cyprus, Nicosia, Cyprus
Puggioni, Francesca; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy ; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy
Quirce, Santiago; Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain
Raciborski, Filip; Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland
Reitsma, Sietze; Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, the Netherlands
Roche, Nicolas; Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, Paris, France ; UMR 1016, Institut Cochin, Paris, France
Rodriguez-Gonzalez, Monica; Pediatric Allergy and Clinical Immunology, Hospital Espanol de Mexico, Mexico City, Mexico
Romantowski, Jan; Department of Allergology, Medical University of Gdańsk, Gdansk, Poland
Sá-Sousa, Ana; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal ; RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Serpa, Faradiba S; Asthma Reference Center - School of Medicine of Santa Casa de Misericórdia of Vitória, Vitoria, Espirito Santo, Brazil
Savouré, Marine ; Inserm, Equipe d'Epidémiologie Respiratoire Intégrative, CESP, Villejuif, France ; Université Paris-Saclay, UVSQ, University Paris-Sud, Villejuif, France
Shamji, Mohamed H ; National Heart and Lung Institute, Imperial College, London, UK ; NIHR Imperial Biomedical Research Centre, London, UK
Sova, Milan; Department of Respiratory Medicine and Tuberculosis, University Hospital, Brno, Czech Republic
Sperl, Annette; Center for Rhinology and Allergology, Wiesbaden, Germany
Stellato, Cristiana; Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy
Todo-Bom, Ana; Imunoalergologia, Centro Hospitalar Universitário de Coimbra, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
Tomazic, Peter Valentin; Department of General ORL, H&NS, Medical University of Graz, ENT-University Hospital Graz, Graz, Steiermark, Austria
Vandenplas, Olivier; Department of Chest Medicine, Centre Hospitalier Universitaire UCL Namur, Namur, Belgique ; Université Catholique de Louvain, Yvoir, Belgium
Van Eerd, Michiel; Peercode BV, Geldermalsen, The Netherlands
Vasankari, Tuula; Fihla, Finnish Lung Association, Helsinki, Finland ; University of Turku, Turku, Finland
Viart, Frédéric; ASA - Advanced Solutions Accelerator, Jacou, France
Waserman, Susan; Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada
Fonseca, Joao A; MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal ; CINTESIS - Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal ; RISE - Health Research Network, MEDCIDS, Faculty of Medicine, University of Porto, Porto, Portugal
Zuberbier, Torsten; Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany ; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany
The authors thank Ms Véronique Pretschner for submitting the paper. MASK‐air has been supported by Charité Universitätsmedizin Berlin, EU grants (EU Structural and Development Funds Languedoc Roussillon and Region PACA; POLLAR: EIT Health; Twinning: EIP on AHA; Twinning DHE: H2020; Catalyse: Horizon Europe) and educational grants from Mylan‐Viatris, ALK, GSK, Novartis, Stallergènes‐Greer and Uriach. None for the study. ®
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