ATP-Dependent Chromatin Remodellers in Inner Ear Development.

Chromatin; Transcription Factors; 8L70Q75FXE (Adenosine Triphosphate); Humans; Transcription Factors/metabolism; Chromatin Assembly and Disassembly; Adenosine Triphosphate/metabolism; Hearing Loss, Sensorineural; cochlea; development; differentiation; epigenetic; hair cells

Abstract :

[en] During transcription, DNA replication and repair, chromatin structure is constantly modified to reveal specific genetic regions and allow access to DNA-interacting enzymes. ATP-dependent chromatin remodelling complexes use the energy of ATP hydrolysis to modify chromatin architecture by repositioning and rearranging nucleosomes. These complexes are defined by a conserved SNF2-like, catalytic ATPase subunit and are divided into four families: CHD, SWI/SNF, ISWI and INO80. ATP-dependent chromatin remodellers are crucial in regulating development and stem cell biology in numerous organs, including the inner ear. In addition, mutations in genes coding for proteins that are part of chromatin remodellers have been implicated in numerous cases of neurosensory deafness. In this review, we describe the composition, structure and functional activity of these complexes and discuss how they contribute to hearing and neurosensory deafness.

Disciplines :

Biochemistry, biophysics & molecular biology
Otolaryngology

Author, co-author :

Chohra, Ilyas ; Université de Liège - ULiège > GIGA > GIGA Stem Cells - Developmental Neurobiology ; Developmental Neurobiology Unit, GIGA-Stem Cells, Av. Hippocrate 15 B, 4000

Chung, Keshi ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie ; Developmental Neurobiology Unit, GIGA-Stem Cells, Av. Hippocrate 15 B, 4000

Giri, Subhajit ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie ; Developmental Neurobiology Unit, GIGA-Stem Cells, Av. Hippocrate 15 B, 4000

Malgrange, Brigitte ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie ; Developmental Neurobiology Unit, GIGA-Stem Cells, Av. Hippocrate 15 B, 4000 Liège

Language :

English

Title :

ATP-Dependent Chromatin Remodellers in Inner Ear Development.

Publication date :

07 February 2023

Journal title :

Cells

eISSN :

2073-4409

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Basel, Ch

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

Funding number :

FNRS-PDR/Fund for Scientific Research/; FLF-005/Fonds Leon fredericq/; FSR-R.CFRA.3775/University of Liège/

Available on ORBi :

since 13 March 2023

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