[en] Klebsiella pneumoniae is on the “critical priority” list for the discovery of new control methods due to its antimicrobial resistance. Responsible of some urinary tract infections (UTIs), the bacteriophage therapy represents a promising alternative against the bacteria. The aim of this study was to isolate and characterize new bacteriophages against a K. pneumoniae isolated from UTI and to assess their efficacy in vitro and in vivo in a Galleria (G.) mellonella larvae model.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Laforêt, Fanny ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH)
Antoine, Céline ; Université de Liège - ULiège > Fundamental and Applied Research for Animals and Health (FARAH)
Pirnay, Jean-Paul; Laboratory for Molecular and Cellular Technology (LabMCT), Astrid Military Hospital, Neder-over-Heembeek, Belgium
Brisse, Sylvain; Institut Pasteur, Université de Paris, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France
Fall, Abdoulaye; Genalyse Partner SA, Herstal, Belgium
Duprez, Jean-Noël ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI)
Delcenserie, Véronique ✱; Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Gestion de la qualité dans la chaîne alimentaire
Thiry, Damien ✱; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Bactériologie vétérinaire et maladies bactériennes animales
✱ These authors have contributed equally to this work.
Language :
English
Title :
Characterization and in vivo assessment of two newly isolated bacteriophages against a ST13 urinary tract infection Klebsiella pneumoniae strain
