Adolescent; Female; Humans; Magnetic Resonance Imaging; Optic Nerve/diagnostic imaging; Optic Nerve/pathology; Brain Neoplasms; Germinoma; Neoplasms, Germ Cell and Embryonal; Oncology; Hematology; Pediatrics, Perinatology and Child Health
Abstract :
[en] Infiltration of the optic pathway by germ cell tumors is exceptional and can lead to confusion with glioma or inflammatory conditions. We present the case of a 14-year-old girl with an optic nerve germinoma extending to the hypothalamus and manifesting as panhypopituitarism and visual loss. The patient experienced spontaneous regression of the lesion followed by secondary deterioration requiring treatment. Four other cases of spontaneously regressing intracranial germinoma followed by regrowth have been reported in the literature. This report highlights the importance of clinical and radiologic monitoring of intracranial germinoma, even in the event of initial spontaneous improvement.
Disciplines :
Pediatrics
Author, co-author :
Geurten, Claire ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pédiatrie ; Departments of Paediatric Haematology/Oncology
Pavon-Mengual, Miriam; Departments of Paediatric Haematology/Oncology
Lo, William B; Paediatric Neuro-Surgery
Bowen, Claire; Pathology
Gagen, Richard; Radiology
Stirling, Heather; Children's and Adolescent Services
Neuling, Kim; Children's and Adolescent Services
Painter, Sally L; Ophthalmology
Williams, Jerald; Ophthalmology ; Department of Ophthalmology, University Hospital Coventry and Warwickshire, Coventry, United Kingdom
Carr, Bryony; Neurophysiology, Birmingham Women and Children's NHS Foundation Trust, Birmingham
English, Martin; Departments of Paediatric Haematology/Oncology
Language :
English
Title :
Optic Nerve Germinoma and Transient Spontaneous Regression-More Than Meets the Eye.
Publication date :
01 July 2022
Journal title :
Journal of Pediatric Hematology/Oncology
ISSN :
1077-4114
eISSN :
1536-3678
Publisher :
Ovid Technologies (Wolters Kluwer Health), United States
Cohen DN, Steinberg M, Buchwald R,. Suprasellar germinomas: diagnostic confusion with optic gliomas. Case Rep J Neurosurg. 1974; 41: 490-493.
Nakajima T, Kumabe T, Jokura H,. Recurrent germinoma in the optic nerve: report of two cases. Neurosurgery. 2001; 48: 214-218.
Woo PYM, Kakaizada S, Chan CCY,. Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. Br J Neurosurg. 2018. Doi: 10.1080/02688697.2018.1519110.
Mascalchi M, Roncaroli F, Salvi F,. Transient regression of an intracranial germ cell tumour after intravenous steroid administration: a case report. J Neurol Neurosurg Psychiatry. 1998; 64: 670-672.
Ide M, Jimbo M, Yamamoto M,. Spontaneous regression of primary intracranial germinoma. A case report. Cancer. 1997; 79: 558-563.
Zhang S, Li Q, Ju Y,. Spontaneous regression in intracranial germinoma: case report and literature review. World Neurosurg. 2019; 131: e32-e37.
Kagawa N, Hirayama R, Fukuya S,. Diagnostic exposure to low-dose radiation and spontaneous regression in intracranial germ cell tumors. Neuro Oncol. 2018; 20 (suppl 2): i87.
