Article (Scientific journals)
Incidence of falls and fall-related injuries and their predictive factors in frail older persons with cancer: a multicenter study.
Kenis, Cindy; Decoster, Lore; Flamaing, Johan et al.
2022In BMC Geriatrics, 22 (1), p. 877
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Keywords :
Cancer; Fall-related injuries; Falls; Frailty; Geriatric assessment; Older persons; Humans; Aged; Aged, 80 and over; Accidental Falls/prevention & control; Incidence; Frail Elderly; Activities of Daily Living; Prospective Studies; Fear; Frailty/diagnosis; Frailty/epidemiology; Neoplasms/diagnosis; Neoplasms/epidemiology; Neoplasms/therapy; Accidental Falls; Neoplasms; Geriatrics and Gerontology
Abstract :
[en] [en] BACKGROUND: Falls and fall-related injuries are a major public health problem. Data on falls in older persons with cancer is limited and robust data on falls within those with a frailty profile are missing. The aim of this study is to investigate the incidence and predictive factors for falls and fall-related injuries in frail older persons with cancer. METHODS: This study is a secondary data analysis from data previously collected in a large prospective multicenter observational cohort study in older persons with cancer in 22 Belgian hospitals (November 2012-February 2015). Patients ≥70 years with a malignant tumor and a frailty profile based on an abnormal G8 score were included upon treatment decision and evaluated with a Geriatric Assessment (GA). At follow-up, data on falls and fall-related injuries were documented. RESULTS: At baseline 2141 (37.2%) of 5759 included patients reported at least one fall in the past 12 months, 1427 patients (66.7%) sustained an injury. Fall-related data of 3681 patients were available at follow-up and at least one fall was reported by 769 patients (20.9%) at follow-up, of whom 289 (37.6%) fell more than once and a fall-related injury was reported by 484 patients (62.9%). Fear of falling was reported in 47.4% of the patients at baseline and in 55.6% of the patients at follow-up. In multivariable analysis, sex and falls history in the past 12 months were predictive factors for both falls and fall-related injuries at follow-up. Other predictive factors for falls, were risk for depression, cognitive impairment, dependency in activities of daily living, fear of falling, and use of professional home care. CONCLUSION: Given the high number of falls and fall-related injuries and high prevalence of fear of falling, multifactorial falls risk assessment and management programs should be integrated in the care of frail older persons with cancer. Further studies with long-term follow-up, subsequent impact on cancer treatment and interventions for fall prevention, and integration of other important topics like medication and circumstances of a fall, are warranted. TRIAL REGISTRATION: B322201215495.
Disciplines :
Oncology
Author, co-author :
Kenis, Cindy;  Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium ; Department of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium ; Department of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven - University of Leuven, Leuven, Belgium
Decoster, Lore;  Department of Medical Oncology, Oncologisch Centrum, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
Flamaing, Johan;  Department of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium ; Department of Public Health and Primary Care, Gerontology and Geriatrics, KU Leuven - University of Leuven, Leuven, Belgium
Debruyne, Philip R;  Department of Medical Oncology, Kortrijk Cancer Centre, AZ Groeninge, Kortrijk, Belgium & Medical Technology Research Centre (MTRC), School of Life Sciences, Faculty of Science and Engineering, Anglia Ruskin University, Cambridge, UK
De Groof, Inge;  Department of Geriatric Medicine, St. Augustinus, Wilrijk, Belgium
Focan, Christian;  Department of Oncology, Clinique CHC Montlégia, Liège, Belgium
Cornélis, Frank;  Department of Medical Oncology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels, Belgium
Verschaeve, Vincent;  Department of Medical Oncology, GHDC Grand Hôpital de Charleroi, Charleroi, Belgium
Bachmann, Christian;  Department of Geriatric Medicine, AZ Sint-Lucas, Ghent, Belgium
Bron, Dominique;  Department of Hematology, ULB Institut Jules Bordet, Brussels, Belgium
Van den Bulck, Heidi;  Department of Medical Oncology, Imelda hospital, Bonheiden, Belgium
Schrijvers, Dirk;  Department of Medical Oncology, ZNA Middelheim, Antwerp, Belgium
Langenaeken, Christine;  Department Medical Oncology, AZ Klina, Brasschaat, Belgium
Specenier, Pol;  Department of Medical Oncology, University Hospital Antwerp, Antwerp, Belgium
Jerusalem, Guy  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service d'oncologie médicale
Praet, Jean-Philippe;  Department of Geriatric Medicine, CHU St-Pierre, Free Universities Brussels, Brussels, Belgium
De Cock, Jessie;  Department of Geriatric Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
Lobelle, Jean-Pierre;  Department of Oncology, Laboratory of Experimental Oncology, KU Leuven - University of Leuven, Leuven, Belgium
Wildiers, Hans;  Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium ; Department of Oncology, KU Leuven - University of Leuven, Leuven, Belgium
Milisen, Koen ;  Department of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium. koen.milisen@kuleuven.be ; Department of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven - University of Leuven, Leuven, Belgium. koen.milisen@kuleuven.be
More authors (10 more) Less
Language :
English
Title :
Incidence of falls and fall-related injuries and their predictive factors in frail older persons with cancer: a multicenter study.
Publication date :
19 November 2022
Journal title :
BMC Geriatrics
eISSN :
1471-2318
Publisher :
BioMed Central Ltd, England
Volume :
22
Issue :
1
Pages :
877
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FOD Volksgezondheid - Federale Overheidsdienst Volksgezondheid - Veiligheid van de Voetselketen en Leefmilieu [BE]
Funding text :
This study was funded by the Cancer Plan 2012–2015, a grant provided by the Federal Public Service of Health, Food Chain Safety and Environment, Belgium (KPC_24_A_025).HW is a recipient of a grant of the ‘Fonds Voor Wetenschappelijk Onderzoek Vlaanderen’ (1802211 N).
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