Article (Scientific journals)
Pathophysiology of the Nondipping Blood Pressure Pattern.
Huart, Justine; Persu, Alexandre; Lengelé, Jean-Philippe et al.
2023In Hypertension
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Keywords :
diurnal rhythm; hypertension; microbiota; nocturnal; nondipper; pathophysiology; Internal Medicine
Abstract :
[en] The nondipping blood pressure (BP) pattern corresponds to a disruption in the circadian BP rhythm with an insufficient decrease in BP levels during night-time sleep as observed using 24-hour ambulatory BP monitoring. Patients with nondipping BP pattern have poorer renal and cardiovascular outcomes, independent of their average 24-hour BP levels. The pathophysiology of nondipping BP is complex and involves numerous mechanisms: perturbations of (1) the circadian rhythm, (2) the autonomic nervous system, and (3) water and sodium regulation. This review provides an outline of the pathways potentially involved in the nondipping BP profile in different conditions. A recent hypothesis is also discussed involving the role of gut microbiota in the dipping/nondipping patterns, via the fecal diet-derived short chain fatty acids.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Huart, Justine  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
Persu, Alexandre ;  Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires Saint-Luc and Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium (A.P., J.-P.L
Lengelé, Jean-Philippe ;  Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires Saint-Luc and Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium (A.P., J.-P.L ; Department of Nephrology, Grand Hôpital de Charleroi, Gilly, Belgium (J.-P.L
Krzesinski, Jean-Marie  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
Jouret, François  ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie
Stergiou, George ;  Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece (G.S
Language :
English
Title :
Pathophysiology of the Nondipping Blood Pressure Pattern.
Publication date :
06 January 2023
Journal title :
Hypertension
ISSN :
0194-911X
eISSN :
1524-4563
Publisher :
Ovid Technologies (Wolters Kluwer Health), United States
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 February 2023

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