Pathophysiology of the Nondipping Blood Pressure Pattern.

[en] The nondipping blood pressure (BP) pattern corresponds to a disruption in the circadian BP rhythm with an insufficient decrease in BP levels during night-time sleep as observed using 24-hour ambulatory BP monitoring. Patients with nondipping BP pattern have poorer renal and cardiovascular outcomes, independent of their average 24-hour BP levels. The pathophysiology of nondipping BP is complex and involves numerous mechanisms: perturbations of (1) the circadian rhythm, (2) the autonomic nervous system, and (3) water and sodium regulation. This review provides an outline of the pathways potentially involved in the nondipping BP profile in different conditions. A recent hypothesis is also discussed involving the role of gut microbiota in the dipping/nondipping patterns, via the fecal diet-derived short chain fatty acids.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Huart, Justine ; Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie

Persu, Alexandre ; Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires Saint-Luc and Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium (A.P., J.-P.L

Lengelé, Jean-Philippe ; Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires Saint-Luc and Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium (A.P., J.-P.L ; Department of Nephrology, Grand Hôpital de Charleroi, Gilly, Belgium (J.-P.L

Krzesinski, Jean-Marie ; Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie

Jouret, François ; Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie

Stergiou, George ; Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece (G.S

Language :

English

Title :

Pathophysiology of the Nondipping Blood Pressure Pattern.

Publication date :

06 January 2023

Journal title :

Hypertension

ISSN :

0194-911X

eISSN :

1524-4563

Publisher :

Ovid Technologies (Wolters Kluwer Health), United States

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.122.19996

Available on ORBi :

since 07 February 2023

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Bibliography

Birkenhäger AM, Van der Meiracker AH,. Causes and consequences of a non-dipping blood pressure profile. Neth J Med. 2007; 65: 127-131.
Stergiou GS, Palatini P, Parati G, O'Brien E, Januszewicz A, Lurbe E, Persu A, Mancia G, Kreutz R,. 2021 European society of hypertension practice guidelines for office and out-of-office blood pressure measurement. J Hypertens. 2021; 39: 1293-1302. doi: 10.1097/hjh.0000000000002843
O'Brien E, Parati G, Stergiou G, Asmar R,. European society of hypertension position paper on ambulatory blood pressure monitoring. J Hypertens. 2013; 31: 1731-1768. doi: 10.1097/HJH.0b013e328363e964
Stergiou GS, Baibas NM, Gantzarou AP, Skeva II,. Reproducibility of home, ambulatory, and clinic blood pressure: implications for the design of trials for the assessment of antihypertensive drug efficacy. Am J Hypertens. 2002; 15 (2 I): 101-104. doi: 10.1016/s0895-7061(01)02324-x
Bo Y, Kwok KO, Chung VCH, Yu C-P, Tsoi KK-F, Wong SY-S,. Short-term reproducibility of ambulatory blood pressure measurements: a systematic review and meta-analysis of 35 observational studies. J Hypertens. 2020; 38: 2095-2109. doi: 10.1097/hjh.0000000000002522
Hinderliter AL, Routledge FS, Blumenthal JA, Koch G,. Reproducibility of blood pressure dipping: relation to day-to-day variability in sleep quality. J Am Soc Hypertens. 2013; 7: 432-439. doi: 10.1016/j.jash.2013.06.001
Stergiou GS, Malakos JS, Zourbaki AS, Achimastos AD, Mountokalakis TD,. Blood pressure during siesta: effect on 24-h ambulatory blood pressure profiles analysis. J Hum Hypertens. 1997; 11: 125-131. doi: 10.1038/sj.jhh.1000383
Gatzka CD, Schmieder RE,. Improved classification of dippers by individualized analysis of ambulatory blood pressure profiles. Am J Hypertens. 1995; 8: 666-671. doi: 10.1016/0895-7061(95)00123-7
Cosgrave J, Phillips J, Haines R, Foster RG, Steinsaltz D, Wulff K,. Revisiting nocturnal heart rate and heart rate variability in insomnia: a polysomnography-based comparison of young self-reported good and poor sleepers. J Sleep Res. 2021; 30: e13278. doi: 10.1111/jsr.13278
O'Brien E, Sheridan J, O'Malley K,. Dippers and non-dippers. Lancet. 1988; 332: 397. doi: 10.1016/s0140-6736(88)92867-x
Fabbian F, Smolensky MH, Tiseo R, Pala M, Manfredini R, Portaluppi F,. Dipper and non-dipper blood pressure 24-hour patterns: circadian rhythm-dependent physiologic and pathophysiologic mechanisms. Chronobiol Int. 2013; 30: 17-30. doi: 10.3109/07420528.2012.715872
Davidson MB, Hix JK, Vidt DG, Brotman DJ,. Association of impaired diurnal blood pressure variation with a subsequent decline in glomerular filtration rate. Arch Intern Med. 2006; 166: 846-852. doi: 10.1001/archinte.166.8.846
Sweiker R, Eber B, Schumacher M, Toplak H, Klein W,. "Non-dipping" related to cardiovascular events in essential hypertensive patients. Acta Med Austriaca. 1994; 21: 86-89.
Mallion JM, Baguet JP, Mancia G,. European society of hypertension scientific newsletter: clinical value of ambulatory blood pressure monitoring. J Hypertens. 2006; 24: 2327-2330. doi: 10.1097/01.hjh.0000249720.05006.d5
Salvetti M, Muiesan ML, Rizzoni D, Bettoni G, Monteduro C, Corbellini C, Viola S, Agabiti-Rosei E,. Night time blood pressure and cardiovascular structure in a middle-aged general population in northern Italy: the vobarno study. J Hum Hypertens. 2001; 15: 879-885. doi: 10.1038/sj.jhh.1001286
Rahman A, Hasan AU, Nishiyama A, Kobori H,. Altered circadian timing system-mediated non-dipping pattern of blood pressure and associated cardiovascular disorders in metabolic and kidney diseases. Int J Mol Sci. 2018; 19: 400. doi: 10.3390/ijms19020400
Poant L, Cerghizan A, Pop D,. Blood pressure pattern and heart rate variability in normotensive patients with type 2 diabetes mellitus. Rom J Intern Med. 2010; 48: 321-327.
Ohkubo T, Hozawa A, Yamaguchi J, Kikuya M, Ohmori K, Michimata M, Matsubara M, Hashimoto J, Hoshi H, Araki T,. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the ohasama study. J Hypertens. 2002; 20: 2183-2189. doi: 10.1097/00004872-200211000-00017
Androulakis E, Papageorgiou N, Chatzistamatiou E, Kallikazaros I, Stefanadis C, Tousoulis D,. Improving the detection of preclinical organ damage in newly diagnosed hypertension: nocturnal hypertension versus non-dipping pattern. J Hum Hypertens. 2015; 29: 689-695. doi: 10.1038/jhh.2015.5
Dolan E, Stanton A, Thijs L, Hinedi K, Atkins N, McClory S, Hond ED, McCormack P, Staessen JA,. Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the dublin outcome study. Hypertension. 2005; 46: 156-161. doi: 10.1161/01.hyp.0000170138.56903.7a
Hansen TW, Li Y, Boggia J, Thijs L, Richart T, Staessen JA,. Predictive role of the nighttime blood pressure. Hypertension. 2011; 57: 3-10. doi: 10.1161/HYPERTENSIONAHA.109.133900
Cuspidi C, Tadic M, Sala C, Gherbesi E, Grassi G, Mancia G,. Extreme dipping: is the cardiovascular risk increased? an unsolved issue. J Hypertens. 2019; 37: 1917-1926. doi: 10.1097/hjh.0000000000002099
Bilo G, Grillo A, Guida V, Parati G,. Morning blood pressure surge: pathophysiology, clinical relevance and therapeutic aspects. Integr Blood Press Control. 2018; 11: 47-56. doi: 10.2147/IBPC.S130277
Kario K, Pickering TG, Umeda Y, Hoshide S, Hoshide Y, Morinari M, Murata M, Kuroda T, Schwartz JE,. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study. Circulation. 2003; 107: 1401-1406. doi: 10.1161/01.cir.0000056521.67546.aa
Muller JE,. Circadian variation in cardiovascular events. Am J Hypertens. 1999; 12: 35S-42S. doi: 10.1016/s0895-7061(98)00278-7
Cho MC,. Clinical significance and therapeutic implication of nocturnal hypertension: relationship between nighttime blood pressure and quality of sleep. Korean Circ J. 2019; 49: 818-828. doi: 10.4070/kcj.2019.0245
Pickering TG, Kario K,. Nocturnal non-dipping: what does it augur?. Curr Opin Nephrol Hypertens. 2001; 10: 611-616. doi: 10.1097/00041552-200109000-00010
Huart J, Cirillo A, Taminiau B,. Human stool metabolome differs upon 24 h blood pressure levels and blood pressure dipping status: a prospective longitudinal study. Metabolites. 2021; 11: 282. doi: 10.3390/metabo11050282
Coca A,. Circadian rhythm and blood pressure control: physiological and pathophysiological factors. JHypertens, Suppl. 1994; 12: S13.
Mahabala C, Kamath P, Bhaskaran U, Pai ND, Pai AU,. Antihypertensive therapy: nocturnal dippers and nondippers. do we treat them differently?. Vasc Health Risk Manag. 2013; 9: 125-133. doi: 10.2147/VHRM.S33515
Middeke M, Klüglich M, Holzgreve H,. Circadian blood pressure rhythm in primary and secondary hypertension. Chronobiol Int. 1991; 8: 451-459. doi: 10.3109/07420529109059181
Zelinka T, Štrauch B, Pecen L, Widimský J,. Diurnal blood pressure variation in pheochromocytoma, primary aldosteronism and Cushing's syndrome. J Hum Hypertens. 2004; 18: 107-111. doi: 10.1038/sj.jhh.1001644
Letizia C, Ferrari P, Cotesta D, Caliumi C, Cianci R, Cerci S, Petramala L, Celi M, Minisola S, D'Erasmo E,. Ambulatory monitoring of blood pressure (AMBP) in patients with primary hyperparathyroidism. J Hum Hypertens. 2005; 19: 901-906. doi: 10.1038/sj.jhh.1001907
Agyemang C, Bhopal R, Bruijnzeels M, Redekop WK,. Does nocturnal blood pressure fall in people of African and South Asian descent differ from that in European white populations? a systematic review and meta-analysis. J Hypertens. 2005; 23: 913-920. doi: 10.1097/01.hjh.0000166827.94699.f9
Stergiou GS, Palatini P, Modesti PA, Asayama K, Asmar R, Bilo G, de la Sierra A, Dolan E, Head G, Kario K,. Seasonal variation in blood pressure: evidence, consensus and recommendations for clinical practice. consensus statement by the European society of hypertension working group on blood pressure monitoring and cardiovascular variability. J Hypertens. 2020; 38: 1235-1243. doi: 10.1097/hjh.0000000000002341
Fava C, Burri P, Almgren P, Arcaro G, Groop L, Lennarthulthen U, Melander O,. Dipping and variability of blood pressure and heart rate at night are heritable traits. Am J Hypertens. 2005; 18: 1402-1407. doi: 10.1016/j.amjhyper.2005.05.011
Norcliffe-Kaufmann L, Slaugenhaupt SA, Kaufmann H,. Familial dysautonomia: history, genotype, phenotype and translational research. Prog Neurobiol. 2017; 152: 131-148. doi: 10.1016/j.pneurobio.2016.06.003
Rimpelä JM, Pörsti IH, Jula A, Lehtimaki T,. Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients. BMC Med Genet. 2018; 19: 1-11. doi: 10.1186/S12881-018-0624-7/FIGURES/3
Tochikubo O, Minamisawa K, Miyakawa T, Miyajima E, Fujiki Y, Ishii M,. Blood pressure during sleep: antihypertensive medication. Am J Cardiol. 1991; 67: B18-B18B25. doi: 10.1016/0002-9149(91)90816-4
Agarwal R,. Regulation of circadian blood pressure: from mice to astronauts. Curr Opin Nephrol Hypertens. 2010; 19: 51-58. doi: 10.1097/mnh.0b013e3283336ddb
Bisognano JD, Bakris G, Nadim MK,. Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled rheos pivotal trial. J Am Coll Cardiol. 2011; 58: 765-773. doi: 10.1016/j.jacc.2011.06.008
Cavelaars M, Tulen JHM, Van Bemmel JH, Mulder PGH, Van Den Meiracker AH,. Reproducibility of intra-arterial ambulatory blood pressure: effects of physical activity and posture. J Hypertens. 2004; 22: 1105-1112. doi: 10.1097/00004872-200406000-00010
Veerman DP, Imholz BPM, Wieling W, Wesseling KH, Van Montfrans GA,. Circadian profile of systemic hemodynamics. Hypertension. 1995; 26: 55-59. doi: 10.1161/01.hyp.26.1.55
Torretti J,. Sympathetic control of renin release. Annu Rev Pharmacol Toxicol. 1982; 22: 167-192. doi: 10.1146/annurev.pa.22.040182.001123
Buijs RM, La Fleur SE, Wortel J, van Heyningen C, Zuiddam L, Mettenleiter TC, Kalsbeek A, Nagai K, Niijima A,. The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons. J Comp Neurol. 2003; 464: 36-48. doi: 10.1002/cne.10765
Zeman M, Dulková K, Bada V, Herichová I,. Plasma melatonin concentrations in hypertensive patients with the dipping and non-dipping blood pressure profile. Life Sci. 2005; 76: 1795-1803. doi: 10.1016/j.lfs.2004.08.034
White WB,. Ambulatory blood pressure monitoring: dippers compared with non-dippers. Blood Press Monit. 2000; 5: S17-S24. doi: 10.1097/00126097-200005001-00004
Golombek DA, Rosenstein RE,. Physiology of circadian entrainment. Physiol Rev. 2010; 90: 1063-1102. doi: 10.1152/physrev.00009.2009
Ekmekcioglu C, Thalhammer T, Humpeler S, Mehrabi MR, Glogar HD, Hölzenbein T, Markovic O, Leibetseder VJ,. The melatonin receptor subtype MT2 is present in the human cardiovascular system. J Pineal Res. 2003; 35: 40-44. doi: 10.1034/j.1600-079x.2003.00051.x
Poirel VJ, Cailotto C, Streicher D, Pévet P, Masson-Pévet M, Gauer F,. MT1 melatonin receptor mRNA tissular localization by PCR amplification. Neuro Endocrinol Lett. 2003; 24: 33-38.
Simko F, Reiter RJ, Pechanova O, Paulis L,. Experimental models of melatonin-deficient hypertension. Front Biosci. 2013; 18: 616-625. doi: 10.2741/4125
Zisapel N,. New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Br J Pharmacol. 2018; 175: 3190-3199. doi: 10.1111/bph.14116
Claustrat B, Brun J, Chazot G,. The basic physiology and pathophysiology of melatonin. Sleep Med Rev. 2005; 9: 11-24. doi: 10.1016/j.smrv.2004.08.001
Jonas M, Garfinkel D, Zisapel N, Laudon M, Grossman E,. Impaired nocturnal melatonin secretion in non-dipper hypertensive patients. Blood Press. 2003; 12: 19-24.
Obayashi K, Saeki K, Iwamoto J, Okamoto N, Tomioka K, Nezu S, Ikada Y, Kurumatani N,. Nocturnal urinary melatonin excretion is associated with non-dipper pattern in elderly hypertensives. Hypertens Res. 2013; 36: 736-740. doi: 10.1038/hr.2013.20
Scheer FAJL, Van Montfrans GA, Van Someren EJW, Mairuhu G, Buijs RM,. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension. 2004; 43 (2 I): 192-197. doi: 10.1161/01.HYP.0000113293.15186.3b
Cavallo A, Daniels SR, Dolan LM, Bean JA, Khoury JC,. Blood pressure-lowering effect of melatonin in type 1 diabetes. J Pineal Res. 2004; 36: 26 - 2266. doi: 10.1111/j.1600-079x.2004.00126.x
Mozdzan M, Mozdzan M, Chaułbiński M, Wojdan K, Broncel M,. The effect of melatonin on circadian blood pressure in patients with type 2 diabetes and essential hypertension. Arch Med Sci. 2014; 10 (4): 669-675. doi: 10.5114/aoms.2014.44858
Brandenberger G, Follenius M, Goichot B, Saini J, Spiegel K, Ehrhart CSJ,. Twenty-four-hour profiles of plasma renin activity in relation to the sleep-wake cycle. J Hypertens. 1994; 12: 277-283.
Clark LA, Denby L, Pregibon D,. A quantitative analysis of the effects of activity and time of day on the diurnal variations of blood pressure. J Chronic. Dis. 1987; 40: 671-681. doi: 10.1016/0021-9681(87)901032
O'Shea JC, Murphy MB,. Nocturnal blood pressure dipping: a consequence of diurnal physical activity blipping?. Am J Hypertens. 2000; 13: 601-606. doi: 10.1016/s0895-7061(99)0
Lusardi P, Zoppi A, Preti P, Pesce RM, Piazza E, Fogari R,. Effects of insufficient sleep on blood pressure in hypertensive patients: a 24-h study. Am J Hypertens. 1999; 12: 63-68. doi: 10.1016/s0895-7061(98)00200-3
Bao X, Nelesen RA, Loredo JS, Dimsdale JE, Ziegler MG,. Blood pressure variability in obstructive sleep apnea: role of sympathetic nervous activity and effect of continuous positive airway pressure. Blood Press Monit. 2002; 7: 301-307. doi: 10.1097/00126097-200212000-00002
Portaluppi F, Cortelli P, Provini F, Plazzi G, Manfredini ELR,. Alterations of sleep and circadian blood pressure profile. Blood Press Monit. 1997; 2: 301-313.
Somers VK, Dyken ME, Mark AL, Abboud FM,. Sympathetic-nerve activity during sleep in normal subjects. N Engl J Med. 1993; 328: 303-307. doi: 10.1056/nejm199302043280502
Pedullaa M, Silvestri R, Lasco A,. Sleep structure in essential hypertensive patients: differences between dippers and non-dippers. Blood Press. 1995; 4: 232-237. doi: 10.3109/08037059509077600
Brandenberger G, Follenius M, Simon C, Ehrhart J, Libert JP,. Nocturnal oscillations in plasma renin activity and REM-NREM sleep cycles in humans: a common regulatory mechanism?. Sleep. 1988; 11: 242-250. doi: 10.1093/sleep/11.3.242
Suzuki M, Guilleminault C, Otsuka K, Shiomi T,. Blood pressure "dipping" and "non-dipping" in obstructive sleep apnea syndrome patients. Sleep. 1996; 19: 382-387. doi: 10.1093/sleep/19.5.382
Sinha AD, Agarwal R,. The complex relationship between CKD and ambulatory blood pressure patterns. Adv Chronic Kidney Dis. 2015; 22: 102-107. doi: 10.1053/j.ackd.2015.01.003
Pepin JL, Borel AL, Tamisier R, Baguet JP, Levy P, Dauvilliers Y,. Hypertension and sleep: overview of a tight relationship. Sleep Med Rev. 2014; 18: 509-519. doi: 10.1016/j.smrv.2014.03.003
Wolf J, Hering D, Narkiewicz K,. Non-dipping pattern of hypertension and obstructive sleep apnea syndrome. Hypertens Res. 2010; 33: 867-871. doi: 10.1038/hr.2010.153
Cuspidi C, Tadic M, Sala C, Gherbesi E, Grassi G, Mancia G,. Blood pressure non-dipping and obstructive sleep apnea syndrome: a meta-analysis. J Clin Med. 2019; 8: 1367. doi: 10.3390/jcm8091367
Panza JA, Epstein SE, Quyyumi AA,. Circadian variation in vascular tone and its relation to α-sympathetic vasoconstrictor activity. N Engl J Med. 1991; 325: 986-990. doi: 10.1056/nejm199110033251402
Dodt C, Breckling U, Derad I, Fehm HL, Born J,. Plasma epinephrine and norepinephrine concentrations of healthy humans associated with nighttime sleep and morning arousal. Hypertension. 1997; 30: 71-76. doi: 10.1161/01.hyp.30.1.71
Narkiewicz K, Winnicki M, Schroeder K, Phillips BG, Kato M, Cwalina E, Somers VK,. Relationship between muscle sympathetic nerve activity and diurnal blood pressure profile. Hypertension. 2002; 39: 168-172. doi: 10.1161/hy1201.097302
Nitsche B, Perschak H, Curt A, Dietz V,. Loss of circadian blood pressure variability in complete tetraplegia. J Hum Hypertens. 1996; 10: 311-317.
Munakata M, Kameyama J, Kanazawa M, Nunokawa T, Moriai N, Yoshinaga K,. Circadian blood pressure rhythm in patients with higher and lower spinal cord injury: simultaneous evaluation of autonomic nervous activity and physical activity. J Hypertens. 1997; 15: 1745-1749. doi: 10.1097/00004872-199715120-00083
Portaluppi F, Bagni B, Uberti ED,. Circadian rhythms of atrial natriuretic peptide, renin, aldosterone, cortisol, blood pressure and heart rate in normal and hypertensive subjects. J Hypertens. 1990; 8: 85-95. doi: 10.1097/00004872-199001000-00013
Kala R, Fyhrquist F, Eisalo A,. Diurnal variation of plasma angiotensin II in man. Scand J Clin Lab Invest. 1973; 31: 363-365. doi: 10.3109/00365517309084318
Goldstein DS, Holmes C, Cannon RO, Eisenhofer G, Kopin IJ,. Sympathetic cardioneuropathy in dysautonomias. N Engl J Med. 1997; 336: 696-702. doi: 10.1056/nejm199703063361004
Kronenberg MW, Forman MB, Onrot J, Robertson D,. Enhanced left ventricular contractility in autonomic failure: assessment using pressure-volume relations. J Am Coll Cardiol. 1990; 15: 1334-1342. doi: 10.1016/s0735-1097(10)80023-3
Shannon JR, Jordan J, Diedrich A, Pohar B, Black BK, Robertson D, Biaggioni I,. Sympathetically mediated hypertension in autonomic failure. Circulation. 2000; 101: 2710-2715. doi: 10.1161/01.cir.101.23.2710
Nelson JA, Alsayed M, Milas M,. The role of parathyroidectomy in treating hypertension and other cardiac manifestations of primary hyperparathyroidism. Gland Surg. 2020; 9: 136-141. doi: 10.21037/gs.2019.12.12
Johansson M, Elam M, Rundqvist B, Eisenhofer G, Herlitz H, Lambert G, Friberg P,. Increased sympathetic nerve activity in renovascular hypertension. Circulation. 1999; 99: 2537-2542. doi: 10.1161/01.cir.99.19.2537
Reeves RA, Shapiro AP, Thompson ME, Johnsen AM,. Loss of nocturnal decline in blood pressure after cardiac transplantation. Circulation. 1986; 73: 401-408. doi: 10.1161/01.cir.73.3.401
Yasuda G, Hasegawa K, Kuji T, Ogawa N, Shimura G, Umemura S, Tochikubo O,. Effects of doxazosin on ambulatory blood pressure and sympathetic nervous activity in hypertensive Type 2 diabetic patients with overt nephropathy. Diabet Med. 2005; 22: 1394-1400. doi: 10.1111/j.1464-5491.2005.01636.x
Krum H, Schlaich M, Whitbourn R, Sobultka PA,. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009; 373: 1275-1281. doi: 10.1016/S0140-6736(09)60566-3
Vallelonga F, Maule S,. Diagnostic and therapeutical management of supine hypertension in autonomic failure: a review of the literature. J Hypertens. 2019; 37: 1102-1111. doi: 10.1097/hjh.0000000000002008
Sachdeva A, Weder AB,. Nocturnal sodium excretion, blood pressure dipping, and sodium sensitivity. Hypertension. 2006; 48: 527-533. doi: 10.1161/01.HYP.0000240268.37379.7c
Kimura G, Dohi Y, Fukuda M,. Salt sensitivity and circadian rhythm of blood pressure: the keys to connect CKD with cardiovascular events. Hypertens Res. 2010; 33: 515-520. doi: 10.1038/hr.2010.47
Fujii T, Uzu T, Nishimura M, Takeji M, Kuroda S, Nakamura S, Inenaga T, Kimura G,. Circadian rhythm of natriuresis is disturbed in nondipper type of essential hypertension. Am J Kidney Dis. 1999; 33: 29-35. doi: 10.1016/s0272-6386(99)70254-4
Creager MA, Roddy MA, Holland KM, Hirsch AT, Dzau VJ,. Sodium depresses arterial baroreceptor reflex function in normotensive humans. Hypertension. 1991; 17: 989-996. doi: 10.1161/01.hyp.17.6.989
Higashi Y, Nakagawa K, Kimura M, Noma K, Hara K, Sasaki S, Goto C, Oshima T, Chayama K, Yoshizumi M,. Circadian variation of blood pressure and endothelial function in patients with essential hypertension: a comparison of dippers and non-dippers. J Am Coll Cardiol. 2002; 40: 2039-2043. doi: 10.1016/s0735-1097(02)02535-4
Chen PY, Sanders PW,. L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. J Clin Invest. 1991; 88: 1559-1567. doi: 10.1172/jci115467
Marcantoni C, Ma LJ, Federspiel C, Fogo AB,. Hypertensive nephrosclerosis in African Americans versus caucasians. Kidney Int. 2002; 62: 172-180. doi: 10.1046/j.1523-1755.2002.00420.x
Eisner GM,. Hypertension: racial differences. Am J Kidney Dis. 1990; 16: 35-40.
Pareek AK, Messerli FH, Chandurkar NB, Dharmadhikari SK, Godbole AV, Kshirsagar PP, Agarwal MA,. Efficacy of low-dose chlorthalidone and hydrochlorothiazide as assessed by 24-h ambulatory blood pressure monitoring. J Am Coll Cardiol. 2016; 67: 379-389. doi: 10.1016/j.jacc.2015.10.083
Uzu T, Ishikawa K, Fujii T, Nakamura S, Inenaga T, Kimura G,. Sodium restriction shifts circadian rhythm of blood pressure from nondipper to dipper in essential hypertension. Circulation. 1997; 96: 1859-1862. doi: 10.1161/01.cir.96.6.1859
Uzu T, Kimura G,. Diuretics shift circadian rhythm of blood pressure from nondipper to dipper in essential hypertension. Circulation. 1999; 100: 1635-1638. doi: 10.1161/01.cir.100.15.1635
Yang T, Santisteban MM, Rodriguez V, Li E, Ahmari N, Carvajal JM, Zadeh M, Gong M, Qi Y,. Gut dysbiosis is linked to hypertension novelty and significance. Hypertension. 2015; 65: 1331-1340. doi: 10.1161/hypertensionaha.115.05315
Yan Q, Gu Y, Li X,. Alterations of the gut microbiome in hypertension. Front Cell Infect Microbiol. 2017; 7: 381. doi: 10.3389/fcimb.2017.00381
Li J, Zhao F, Wang Y,. Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome. 2017; 5: 14. doi: 10.1186/s40168-016-0222-x
Kim S, Goel R, Kumar A,. Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure. Clin Sci (Lond). 2018; 132: 701-718. doi: 10.1042/CS20180087
Meijers B, Jouret F, Evenepoel P,. Linking gut microbiota to cardiovascular disease and hypertension: lessons from chronic kidney disease. Pharmacol Res. 2018; 133: 101-107. doi: 10.1016/j.phrs.2018.04.023
Butel M-J,. Probiotics, gut microbiota and health. Méd Mal Infect. 2014; 44: 1-8. doi: 10.1016/j.medmal.2013.10.002
Robles Alonso V, Guarner F,. Linking the gut microbiota to human health. Br J Nutr. 2013; 109: S21-S26. doi: 10.1017/s0007114512005235
Raizada MK, Joe B, Bryan NS, Chang EB, Dewhirst FE, Borisy GG, Galis ZS,. Report of the national heart, lung, and blood institute working group on the role of microbiota in blood pressure regulation. Hypertension. 2017; 70: 479-485. doi: 10.1161/hypertensionaha.117.09699
Van Hul M, Geurts L, Plovier H, Druart C,. Reduced obesity, diabetes, and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier. Am J Physiol Metab. 2018; 314: E334-E352. doi: 10.1152/ajpendo.00107.2017
Duparc T, Plovier H, Marrachelli VG, Hull MV,. Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism. Gut. 2017; 66: 620-632. doi: 10.1136/gutjnl-2015-310904
Chakraborty S, Mandal J, Cheng X, Galla S, Hindupur A, Saha P, Yeoh BS, Mell B, Yeo J-Y,. Diurnal timing dependent alterations in gut microbial composition are synchronously linked to salt-sensitive hypertension and renal damage. Hypertension. 2020; 76: 59-72. doi: 10.1161/hypertensionaha.120.14830
Bartolomaeus H, Markó L, Wilck N, Luft FC, Forslund SK, Muller DN,. Precarious symbiosis between host and microbiome in cardiovascular health. Hypertension. 2019; 73: 926-935. doi: 10.1161/hypertensionaha.119.11786
Miyamoto J, Kasubuchi M, Nakajima A, Irie J, Itoh H, Kimura I,. The role of short-chain fatty acid on blood pressure regulation. Curr Opin Nephrol Hypertens. 2016; 25: 379-383. doi: 10.1097/mnh.0000000000000246
de la Cuesta-Zuluaga J, Mueller NT, Álvarez-Quintero R,. Higher fecal short-chain fatty acid levels are associated with gut microbiome dysbiosis, obesity, hypertension and cardiometabolic disease risk factors. Nutrients. 2019; 11: 51. doi: 10.3390/nu11010051
Pluznick JL,. Microbial short-chain fatty acids and blood pressure regulation. Curr Hypertens Rep. 2017; 19: 25. doi: 10.1007/s11906-017-0722-5
Huart J, Leenders J, Taminiau B, Descy J, Saint-Remy A, Daube G, Krzesinski J-M, Melin P, de Tullio P,. Gut microbiota and fecal levels of short-chain fatty acids differ upon 24-hour blood pressure levels in men. Hypertension. 2019; 74: 1005-1013. doi: 10.1161/hypertensionaha.118.12588
Sun S, Lulla A, Sioda M, Winglee K, Wu MC, Jacobs DR, Shikany JM,. Gut Microbiota composition and blood pressure. Hypertension. 2019; 73: 998-1006. doi: 10.1161/hypertensionaha.118.12109
Huart J, Cirillo A, Saint-Remy A, Krzesinski JM, de Tullio P, Jouret F,. The faecal abundance of short chain fatty acids is increased in men with a non-dipping blood pressure profile. Acta Cardiol. 2021; 77: 1-4. doi: 10.1080/00015385.2021.1901020
Hermida RC, Ayala DE, Mojón A, Fernández JR,. Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study. Chronobiol Int. 2010; 27: 1629-1651. doi: 10.3109/07420528.2010.510230
Hermida RC, Crespo JJ, Domínguez-Sardiña M,. Bedtime hypertension treatment improves cardiovascular risk reduction: the hygia chronotherapy trial. Eur Heart J. 2020; 41: 4565-4576. doi: 10.1093/eurheartj/ehz754
Kreutz R, Kjeldsen SE, Burnier M, Narkiewicz K, Oparil S, Mancia G,. Disregard the reported data from the HYGIA project: blood pressure medication not to be routinely dosed at bedtime. J Hypertens. 2020; 38: 2144-2145. doi: 10.1097/hjh.0000000000002671
Turgeon RD, Althouse AD, Cohen JB, Enache B, Hogenesch JB, Johansen ME, Mehta R, Meyerowitz-Katz G,. Lowering nighttime blood pressure with bedtime dosing of antihypertensive medications: controversies in hypertension-con side of the argument. Hypertension. 2021; 78: 871-878. doi: 10.1161/hypertensionaha.121.16501
Burnier M, Kreutz R, Narkiewicz K, Kjeldsen S, Oparil S, Mancia G,. Circadian variations in blood pressure and their implications for the administration of antihypertensive drugs: is dosing in the evening better than in the morning?. J Hypertens. 2020; 38: 1396-1406. doi: 10.1097/hjh.0000000000002532
Oxlund CS, Henriksen JE, Tarnow L, Schousboe K, Gram J, Jacobsen IA,. Lowdose spironolactone reduces blood pressure in patients with resistant hypertension and type 2 diabetes mellitus: a double blind randomized clinical trial. J Hypertens. 2013; 31: 2094-2102. doi: 10.1097/hjh.0b013e3283638b1a
Kario K, Okada K, Kato M, Nishizawa M, Yoshida T, Asano T, Uchiyama K, Niijima Y, Katsuya T, Urata H,. Twenty-four-hour blood pressure-lowering effect of a sodium-glucose cotransporter 2 inhibitor in patients with diabetes and uncontrolled nocturnal hypertension: results from the randomized, placebo-controlled SACRA study. Circulation. 2019; 139: 2089-2097. doi: 10.1161/circulationaha.118.037076