[en] ("[en] BACKGROUND: Previous literature on the determinants of diaphragm dysfunction in septic patients is limited. The goal of this study is to assess diaphragm dysfunction in terms of its prevalence and its potential associated factors in septic intensive care unit (ICU) patients.
METHODS: This prospective and observational study was conducted between June 2015 and July 2019. Ultrasound measures of diaphragm thickness were performed daily on septic patients. The primary outcome was the prevalence of diaphragm dysfunction at baseline and during the ICU stay. The secondary outcome was the diaphragm thickness. Possible associated factors were prospectively recorded.
RESULTS: Fifty patients were enrolled in the study. The prevalence of diaphragm dysfunction was 58%. No diaphragm atrophy was found during the ICU stay. Diaphragm dysfunction was associated with the alteration of consciousness, intra-abdominal sepsis, hypnotics and opioids, and mechanical ventilation. Administration of hypnotics, opioids, and steroids was associated with a decreased diaphragm thickening fraction. Diaphragm dysfunction had no impact on patient outcomes.
CONCLUSIONS: Our data reveal a high prevalence of diaphragm dysfunction in septic patients at the onset of sepsis. Administration of hypnotics, opioids, and steroids was associated with the alteration of diaphragm function as well as intra-abdominal sepsis.","[en] ","")
Disciplines :
Anesthesia & intensive care
Author, co-author :
Le Neindre, Aymeric ; Respiratory Intensive Care and Clinical Research Units, Hôpital Forcilles, Férolles-Attilly, France, LNC UMR1231, University of Bourgogne Franche-Comté, Dijon, France. Electronic address: aymeric.leneindre@gmail.com
Wormser, Johan ; Intensive Care Unit, Groupe Hospitalier Paris Saint-Joseph, Paris, France
Luperto, Marta; Intensive Care Unit, Hôpital Antoine Béclère, Clamart, France
Bruel, Cédric; Intensive Care Unit, Groupe Hospitalier Paris Saint-Joseph, Paris, France
Misset, Benoît ; Centre Hospitalier Universitaire de Liège - CHU > > Service des soins intensifs
Bouhemad, Belaid; LNC UMR1231, University of Bourgogne Franche-Comté, Dijon, France, Department of Anesthesiology and Intensive Care, University Hospital of Dijon, Dijon, France
Philippart, François; Intensive Care Unit, Groupe Hospitalier Paris Saint-Joseph, Paris, France, Institute for Integrative Cell Biology, Microbiology: Endotoxins, Structures and Host Response, Gif-sur-Yvette, France
Language :
English
Title :
Diaphragm function in patients with sepsis and septic shock: A longitudinal ultrasound study.
Publication date :
07 March 2022
Journal title :
Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
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