Non-smoker; Oral tongue; Risk factors; Squamous cell carcinoma; Young patients; Humans; Neoplasm Recurrence, Local/epidemiology; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck; Carcinoma, Squamous Cell/epidemiology; Head and Neck Neoplasms; Tongue Neoplasms/epidemiology; Carcinoma, Squamous Cell; Neoplasm Recurrence, Local; Tongue Neoplasms; Otorhinolaryngology; General Medicine
Abstract :
[en] ("[en] BACKGROUND: Incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing, especially in young adults, despite decreasing tobacco and alcohol consumption.
METHODS: This multicentric retrospective study of 185 young adults with OTSCC (median follow-up 43 months), investigated risk factors, tumour characteristics and oncological outcomes according to the smoking status.
RESULTS: Overall, 38% of patients were smokers (S). Non-smokers (NS) were significantly younger than S. Sex ratios were 1.1 for N and 1.8 for S. NS patients were less frequently cannabis or alcohol users than S, but were more likely to have a history of leukoplakia. Second primaries were observed in NS (4.4%) and in S (12.7%). Despite more frequent local relapse in NS (p = 0.018), there was no difference in diagnostic stage and overall survival between groups.
CONCLUSION: OTSCC affects differently young S and NS patients suggesting the existence of a specific clinical entity of OTSCC in non-smoking young adults.","[en] ","")
Disciplines :
Otolaryngology
Author, co-author :
Deneuve, Sophie ; Surgical Oncology Department, Léon Bérard Comprehensive Cancer Center, 28 rue Laennec, 69008, Lyon, France. fdeneuve@club.fr ; INSERM UA8, Radiation: Défense, Santé , Environnement, Lyon, France. fdeneuve@club.fr
Guerlain, Joanne; Head and Neck Department, Gustave Roussy Comprehensive Cancer Center, Villejuif, France
Dupret-Bories, Agnès; Head and Neck Department, Toulouse University Cancer Institute, Toulouse, France
Majoufre, Claire; Maxillofacial Surgery, CHU Bordeaux Pellegrin, Bordeaux, France
Philouze, Pierre; ENT Department, CHU Croix Rousse, Lyon, France
Ceruse, Philippe; ENT Department, CHU Croix Rousse, Lyon, France
Perreard, Marion; ENT Department, CHU Caen, Caen, France
Sigaud, Nicolas; Maxillofacial Surgery, CHU Lyon Sud, Pierre-Bénite, France
Barry, Béatrix; ENT Department, CHU Bichat, Paris, France
Ransy, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'ORL, d'audiophonologie et de chir. cervico-faciale
Schultz, Philippe; ENT Department, CHU Strasbourg, Strasbourg, France
Malard, Olivier; ENT Department, CHU Nantes, Nantes, France
Morinière, Sylvain; ENT Department, CHU Tours, Tours, France
Chatellier, Anne; Maxillofacial Surgery, CHU Caen, Caen, France
De Monès, Erwan; ENT Department, CHU Bordeaux, Bordeaux, France
Folia, Mireille; ENT Department, CHU Dijon, Dijon, France
Virard, François; INSERM U1052-CNRS UMR5286, Cancer Research Center, centre Léon Berard, Lyon 1 University, Lyon, France ; Université de Lyon, Faculté d'Odontologie, Hospices Civils de Lyon, Lyon, France
Fervers, Béatrice; INSERM UA8, Radiation: Défense, Santé , Environnement, Lyon, France ; Cancer and Environnement Department, Léon Bérard Comprehensive Cancer Center, Lyon, France
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