Allogeneic hematopoietic cell transplantation; BK polyomavirus; Cidofovir; Endovesical instillation; Hemorrhagic cystitis; Biochemistry, Genetics and Molecular Biology (all); General Biochemistry, Genetics and Molecular Biology; General Medicine
Abstract :
[en] ("[en] BACKGROUND: Hemorrhagic cystitis (HC) with BK polyomavirus (BKPyV) is a common complication after allogeneic hematopoietic cell transplantation (alloHCT) that may lead to severe discomfort for the patient and significant morbidity (urinary obstruction, increased transfusion requirements and prolonged hospitalization). So far, there is no clear consensus on how to manage this complication.
PATIENTS AND METHODS: Here, we report a single-center case series of 9 patients (4 children and 5 adults) treated with cidofovir endovesical (EV) instillation(s) for BKPyV-HC after alloHCT. EV Cidofovir was administered at a dose of 5 mg/kg, for 1 to 3 instillations (with a minimum delay between 2 successive doses of 5 days).
RESULTS: Eight out of the 9 treated patients with EV Cidofovir achieved a complete resolution of HC after 1-3 instillation(s), without recurrence of symptomatic infection within the next 3 months. Only 1 adult patient did not improve after treatment and developed severe morbidity (emphysematous cystitis).
CONCLUSION: Although this single-center case series of EV cidofovir for BKPyV HC after alloHCT shows encouraging results, only large prospective studies will definitively establish the effectiveness of this therapy.","[en] ","")
Disciplines :
Hematology
Author, co-author :
Voisot, Adrien; Department of Clinical Hematology, University Hospital of Liège, CHU Sart-Tilman, 4000 Liège, Belgium
Triffaux, François ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'urologie
Roland, Isabelle ; Centre Hospitalier Universitaire de Liège - CHU > > Service production et essais cliniques
Meex, Cécile ; Centre Hospitalier Universitaire de Liège - CHU > > Service de microbiologie clinique
Detrembleur, Nancy ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'anatomie et cytologie pathologiques
Baron, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
WILLEMS, Evelyne ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
WALTREGNY, David ; Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Service d'urologie
Beguin, Yves ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Servais, Sophie ; Centre Hospitalier Universitaire de Liège - CHU > > Service d'hématologie clinique
Language :
English
Title :
Endovesical instillation of Cidofovir in the treatment of BK polyomavirus hemorrhagic cystitis after allogeneic hematopoietic cell transplantation.
S Servais is Postdoctoral Researcher at the Belgian Foundation against Cancer (FBC). F Baron is Senior Research Associate at the National Fund for Scientific Research (FNRS) Belgium. The study was supported by funds from the Belgian Foundation against Cancer (FBC), the National Fund for Scientific Research (FNRS), the Anti-Cancer Center and the Leon Fredericq Foundation from the University of Liege.
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