[en] ("[en] BACKGROUND AND PURPOSE: The frequency of seizures is an important factor that can alter functional brain connectivity. Analysis of this factor in patients with epilepsy is complex because of disease- and medication-induced confounders. Because patients with hot-water epilepsy generally are not on long-term drug therapy, we used seed-based connectivity analysis in these patients to assess connectivity changes associated with seizure frequency without confounding from antiepileptic drugs.
MATERIALS AND METHODS: Resting-state fMRI data from 36 patients with hot-water epilepsy (18 with frequent seizures [>2 per month] and 18 with infrequent seizures [≤2 per month]) and 18 healthy age- and sex-matched controls were analyzed for seed-to-voxel connectivity by using 106 seeds. Voxel wise paired t-test analysis (P < .005, corrected for false-discovery rate) was used to identify significant intergroup differences between these groups.
RESULTS: Connectivity analysis revealed significant differences between the 2 groups (P < .001). Patients in the frequent-seizure group had increased connectivity within the medial temporal structures and widespread areas of poor connectivity, even involving the default mode network, in comparison with those in the infrequent-seizure group. Patients in the infrequent-seizure group had focal abnormalities with increased default mode network connectivity and decreased left entorhinal cortex connectivity.
CONCLUSIONS: The results of this study suggest that seizure frequency can alter functional brain connectivity, which can be visualized by using resting-state fMRI. Imaging features such as diffuse network abnormalities, involvement of the default mode network, and recruitment of medial temporal lobe structures were seen only in patients with frequent seizures. Future studies in more common epilepsy groups, however, will be required to further establish this finding.","[en] ","")
Disciplines :
Neurology
Author, co-author :
Bharath, R D; From the Departments of Neuroimaging and Interventional Radiology (R.D.B., R.P., L.G., A.G.) Advanced Brain Imaging Facility (R.D.B., R.P.), Cognitive Neuroscience Center, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India
Sinha, S; Neurology (S.S., K.R., G.C., P.S
Panda, Rajanikant ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; From the Departments of Neuroimaging and Interventional Radiology (R.D.B., R.P., L.G., A.G.) Advanced Brain Imaging Facility (R.D.B., R.P.), Cognitive Neuroscience Center, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India
Raghavendra, K; Neurology (S.S., K.R., G.C., P.S
George, L; From the Departments of Neuroimaging and Interventional Radiology (R.D.B., R.P., L.G., A.G
Chaitanya, G; Neurology (S.S., K.R., G.C., P.S
Gupta, A; From the Departments of Neuroimaging and Interventional Radiology (R.D.B., R.P., L.G., A.G
Morgan VL, Rogers BP, Sonmezturk HH, et al. Cross hippocampal influence in mesial temporal lobe epilepsy measured with high temporal resolution functional magnetic resonance imaging. Epilepsia 2011;52:1741-49 CrossRef Medline
Bettus G, Guedj E, Joyeux F, et al. Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms. Hum Brain Mapp 2009;30:1580-91 CrossRef Medline
Bettus G, Bartolomei F, Confort-Gouny S, et al. Role of resting state functional connectivity MRI in presurgical investigation of mesial temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 2010;81: 1147-54 CrossRef Medline
Pereira FR, Alessio A, Sercheli MS, et al. Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI. BMC Neurosci 2010;11:66 CrossRef Medline
Pittau F, Grova C, Moeller F, et al. Patterns of altered functional connectivity in mesial temporal lobe epilepsy. Epilepsia 2012;53: 1013-23 CrossRef Medline
Zhang Z, Lu G, Zhong Y, et al. Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy. Brain Res 2010;1323:152-60 CrossRef Medline
Jehi LE. Functional connectivity in mesial temporal lobe epilepsy: a dynamic concept. Epilepsy Curr 2012;12:238-40 CrossRef Medline
Liao W, Zhang Z, Pan Z, et al. Altered functional connectivity and small-world in mesial temporal lobe epilepsy. PLoS One 2010;5: e8525 CrossRef Medline
Morgan VL, Sonmezturk HH, Gore JC, et al. Lateralization of temporal lobe epilepsy using resting functional magnetic resonance imaging connectivity of hippocampal networks. Epilepsia 2012;53: 1628-35 CrossRef Medline
Maccotta L, He BJ, Snyder AZ, et al. Impaired and facilitated functional networks in temporal lobe epilepsy. Neuroimage Clin 2013;2: 862-72 CrossRef Medline
van Dellen E, Douw L, Baayen JC, et al. Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordings. PLoS One 2009;4:e8081 CrossRef Medline
Zhang Z, Lu G, Zhong Y, et al. fMRI study of mesial temporal lobe epilepsy using amplitude of low-frequency fluctuation analysis. Hum Brain Mapp 2010;31:1851-61 CrossRef Medline
Vlooswijk MC, Jansen JF, Majoie HJ, et al. Functional connectivity and language impairment in cryptogenic localization-related epilepsy. Neurology 2010;75:395-402 CrossRef Medline
Wang Z, Lu G, Zhang Z, et al. Altered resting state networks in epileptic patients with generalized tonic-clonic seizures. Brain Res 2011;1374:134-41 CrossRef Medline
Weaver KE, Chaovalitwongse WA, Novotny EJ, et al. Local functional connectivity as a pre-surgical tool for seizure focus identification in non-lesion, focal epilepsy. Front Neurol 2013;4:43 CrossRef Medline
Fahoum F, Lopes R, Pittau F, et al. Widespread epileptic networks in focal epilepsies: EEG-fMRI study. Epilepsia 2012;53:1618-27 CrossRef Medline
Laufs H, Lengler U, Hamandi K, et al. Linking generalized spikeand-wave discharges and resting state brain activity by using EEG/fMRI in a patient with absence seizures. Epilepsia 2006;47:444-48 CrossRef Medline
Moeller F, LeVan P, Muhle H, et al. Absence seizures: individual patterns revealed by EEG-fMRI. Epilepsia 2010;51:2000-10 CrossRef Medline
Walker MC, White HS, Sander JW. Disease modification in partial epilepsy. Brain 2002;125:1937-50 CrossRef Medline
Morimoto K, Fahnestock M, Racine RJ. Kindling and status epilepticus models of epilepsy: rewiring the brain. Prog Neurobiol 2004;73: 1-60 CrossRef Medline
Cavazos JE, Golarai G, Sutula TP. Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence. J Neurosci 1991;11:2795-803 Medline
Sutula T, Koch J, Golarai G, et al. NMDA receptor dependence of kindling and mossy fiber sprouting: evidence that the NMDA receptor regulates patterning of hippocampal circuits in the adult brain. J Neurosci 1996;16:7398-406 Medline
Hauser WA, Lee JR. Do seizures beget seizures? Prog Brain Res 2002; 135:215-19 CrossRef Medline
Widjaja E, Zamyadi M, Raybaud C, et al. Impaired default mode network on resting-state fMRI in children with medically refractory epilepsy. AJNR Am J Neuroradiol 2013;34:552-57 CrossRef Medline
Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia 2010;51:676-85 CrossRef Medline
Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia 2014;55:475-82 CrossRef Medline
Tzourio-Mazoyer N, Landeau B, Papathanassiou D, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002;15:273-89 CrossRef Medline
Fornito A, Zalesky A, Bullmore ET. Network scaling effects in graph analytic studies of human resting-state fMRI data. Front Syst Neurosci 2010;4:22 CrossRef Medline
Zalesky A, Fornito A, Harding IH, et al. Whole-brain anatomical networks: does the choice of nodes matter? Neuroimage 2010;50: 970-83 CrossRef Medline
Whitfield-Gabrieli S, Ford JM. Default mode network activity and connectivity in psychopathology. Annu Rev Clin Psychol 2012;8: 49-76 CrossRef Medline
Behzadi Y, Restom K, Liau J, et al. A component based noise correction method (CompCor) forBOLDand perfusion based fMRI. Neuroimage 2007;37:90-101 CrossRef Medline
Whitfield-Gabrieli S, Nieto-Castanon A. Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connect 2012;2:125-41 CrossRef Medline
Woodward ND, Rogers B, Heckers S. Functional resting-state networks are differentially affected in schizophrenia. Schizophr Res 2011;130:86-93 CrossRef Medline
Satishchandra P. Hot-water epilepsy. Epilepsia 2003;44:29-32 CrossRef Medline
Luo C, Li Q, Lai Y, et al. Altered functional connectivity in default mode network in absence epilepsy: a resting-state fMRI study. Hum Brain Mapp 2011;32:438-49 CrossRef Medline
Luo C, Li Q, Xia Y, et al. Resting state basal ganglia network in idiopathic generalized epilepsy. Hum Brain Mapp 2012;33:1279-94 CrossRef Medline
Bai X, Guo J, Killory B, et al. Resting functional connectivity between the hemispheres in childhood absence epilepsy. Neurology 2011;76:1960-67 CrossRef Medline
Killory BD, Bai X, Negishi M, et al. Impaired attention and network connectivity in childhood absence epilepsy. Neuroimage 2011;56: 2209-17 CrossRef Medline
Maneshi M, Moeller F, Fahoum F, et al. Resting-state connectivity of the sustained attention network correlates with disease duration in idiopathic generalized epilepsy. PLoS One 2012;7:e50359 CrossRef Medline
Satishchandra P, Shivaramakrishana A, Kaliaperumal VG, et al. Hotwater epilepsy: a variant of reflex epilepsy in southern India. Epilepsia 1988;29:52-56 CrossRef Medline
Satishchandra P, Ullal GR, Shankar SK. Hot water epilepsy. Adv Neurol 1998;75:283-93 Medline
Szymonowicz W, Meloff K. Hot water epilepsy. Can J Neurol Sci 1978;5:247-51 Medline
Meghana A, Sinha S, Sathyaprabha TN, et al. Hot water epilepsy clinical profile and treatment-a prospective study. Epilepsy Res 2012;102:160-66 CrossRef Medline
Patel M, Satishchandra P, Saini J, et al. Eating epilepsy: phenotype, MRI, SPECT and video-EEG observations. Epilepsy Res 2013;107: 115-20 CrossRef Medline
Sandhya M, Bharath RD, Panda R, et al. Understanding the pathophysiology of reflex epilepsy using simultaneous EEG-fMRI. Epileptic Disord 2014;16:19-29 CrossRef Medline
Ullal GR, Satishchandra P, Kalladka D, et al. Kindling & mossy fibre sprouting in the rat hippocampus following hot water induced hyperthermic seizures. Indian J Med Res 2006;124:331-42 Medline
Greicius MD, Flores BH, Menon V, et al. Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol Psychiatry 2007;62:429-37 CrossRef Medline