brain plasticity; hyper connectivity; longitudinal study; mild traumatic brain injury; resting state functional connectivity; time varying changes; Neuropsychology and Physiological Psychology; Neurology; Psychiatry and Mental Health; Biological Psychiatry; Behavioral Neuroscience
Abstract :
[en] Brains reveal amplified plasticity as they recover from an injury. We aimed to define time dependent plasticity changes in patients recovering from mild traumatic brain injury (mTBI). Twenty-five subjects with mild head injury were longitudinally evaluated within 36 h, 3 and 6 months using resting state functional connectivity (RSFC). Region of interest (ROI) based connectivity differences over time within the patient group and in comparison with a healthy control group were analyzed at p < 0.005. We found 33 distinct ROI pairs that revealed significant changes in their connectivity strength with time. Within 3 months, the majority of the ROI pairs had decreased connectivity in mTBI population, which increased and became comparable to healthy controls at 6 months. Within this diffuse decreased connectivity in the first 3 months, there were also few regions with increased connections. This hyper connectivity involved the salience network and default mode network within 36 h, and lingual, inferior frontal and fronto-parietal networks at 3 months. Our findings in a fairly homogenous group of patients with mTBI evaluated during the 6 month window of recovery defines time varying brain connectivity changes as the brain recovers from an injury. A majority of these changes were seen in the frontal and parietal lobes between 3 and 6 months after injury. Hyper connectivity of several networks supported normal recovery in the first 6 months and it remains to be seen in future studies whether this can predict an early and efficient recovery of brain function.
Disciplines :
Neurology
Author, co-author :
Bharath, Rose D; Advanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences Bangalore, India , Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India
Munivenkatappa, Ashok; Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences Bangalore, India
Gohel, Suril; Department of Biomedical Engineering, New Jersey Institute of Technology, University Heights Newark, NJ, USA
Panda, Rajanikant ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Advanced Brain Imaging Facility, Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences Bangalore, India , Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India
Saini, Jitender; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences Bangalore, India
Rajeswaran, Jamuna; Neuropsychology Unit, Department of Clinical Psychology, National Institute of Mental Health and Neurosciences Bangalore, India
Shukla, Dhaval; Department of Neurosurgery, National Institute of Mental Health and Neurosciences Bangalore, India
Bhagavatula, Indira D; Department of Neurosurgery, National Institute of Mental Health and Neurosciences Bangalore, India
Biswal, Bharat B; Department of Biomedical Engineering, New Jersey Institute of Technology, University Heights Newark, NJ, USA
Language :
English
Title :
Recovery of resting brain connectivity ensuing mild traumatic brain injury.
Publication date :
2015
Journal title :
Frontiers in Human Neuroscience
eISSN :
1662-5161
Publisher :
Frontiers Media S. A, Switzerland
Volume :
9
Issue :
September
Pages :
513
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Ministry of Science and Technology. Department of Science and Technology [IN]
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