[en] ("[en] BACKGROUND: Patients with Parkinson's disease (PD) may develop several gait disturbances during the course of illness and Freezing of gait (FOG) is one of them. Several neuroimaging studies have been conducted to identify the neural correlates of FOG but results have not been uniform. Resting state functional MRI (rs-fMRI) is relatively less explored in PD patients with FOG. This study aims to compare the whole brain resting state connectivity of PD patients with and without FOG using rs-fMRI.
METHODS: rs-fMRI was obtained for 28 PD patients (15 with and 13 patients without FOG) who were matched for various demographic and clinical characteristics. Seed to voxel analysis was performed at whole brain level and compared between the two groups.
RESULTS: When compared to patients without FOG, the patients with FOG had reduced functional connectivity across multiple seeds. Major finding was reduced inter-hemispheric connectivity of left parietal opercular cortex with multiple regions of the brain primarily involving the primary somatosensory and auditory areas, which also negatively correlated with the FOGQ scores.
CONCLUSION: Our findings suggest that alterations in the resting state functional connectivity of the opercular parietal cortex may be one of the substrates of FOG. Reduced interhemispheric connectivity probably is the reason for impairment of control and coordination in bilateral leg movements while walking.","[en] ","")
Disciplines :
Neurology
Author, co-author :
Lenka, Abhishek; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India, Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Naduthota, Rajini M; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Jha, Menka; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Panda, Rajanikant ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Prajapati, Arvind ; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Jhunjhunwala, Ketan; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India, Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Saini, Jitender; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Yadav, Ravi; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Bharath, Rose Dawn; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India. Electronic address: drrosedawn@yahoo.com
Pal, Pramod Kumar; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India. Electronic address: pal.pramod@rediffmail.com
Language :
English
Title :
Freezing of gait in Parkinson's disease is associated with altered functional brain connectivity.
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