[en] ("[en] BACKGROUND: Patients with Parkinson's disease (PD) may develop several gait disturbances during the course of illness and Freezing of gait (FOG) is one of them. Several neuroimaging studies have been conducted to identify the neural correlates of FOG but results have not been uniform. Resting state functional MRI (rs-fMRI) is relatively less explored in PD patients with FOG. This study aims to compare the whole brain resting state connectivity of PD patients with and without FOG using rs-fMRI.
METHODS: rs-fMRI was obtained for 28 PD patients (15 with and 13 patients without FOG) who were matched for various demographic and clinical characteristics. Seed to voxel analysis was performed at whole brain level and compared between the two groups.
RESULTS: When compared to patients without FOG, the patients with FOG had reduced functional connectivity across multiple seeds. Major finding was reduced inter-hemispheric connectivity of left parietal opercular cortex with multiple regions of the brain primarily involving the primary somatosensory and auditory areas, which also negatively correlated with the FOGQ scores.
CONCLUSION: Our findings suggest that alterations in the resting state functional connectivity of the opercular parietal cortex may be one of the substrates of FOG. Reduced interhemispheric connectivity probably is the reason for impairment of control and coordination in bilateral leg movements while walking.","[en] ","")
Disciplines :
Neurology
Author, co-author :
Lenka, Abhishek; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India, Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Naduthota, Rajini M; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Jha, Menka; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Panda, Rajanikant ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Prajapati, Arvind ; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Jhunjhunwala, Ketan; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India, Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Saini, Jitender; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Yadav, Ravi; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
Bharath, Rose Dawn; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India. Electronic address: drrosedawn@yahoo.com
Pal, Pramod Kumar; Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India. Electronic address: pal.pramod@rediffmail.com
Language :
English
Title :
Freezing of gait in Parkinson's disease is associated with altered functional brain connectivity.
Jankovic J. Parkinson's disease: clinical features and diagnosis. J. Neurol. Neurosurg. Psychiatry 2008, 79:368-376. 10.1136/jnnp.2007.131045.
Giladi N., Nieuwboer A. Understanding and treating freezing of gait in Parkinsonism, proposed working definition, and setting the stage. Mov. Disord. 2008, 23:302-305. 10.1002/mds.21927.
Amboni M., Stocchi F., Abbruzzese G., Morgante L., Onofrj M., Ruggieri S., et al. Prevalence and associated features of self-reported freezing of gait in Parkinson disease: the DEEP FOG study. Park. Relat. Disord. 2015, 21:644-649. 10.1016/j.parkreldis.2015.03.028.
Giladi N., McDermott M.P., Fahn S., Przedborski S., Jankovic J., Stern M., et al. Freezing of Gait in PD: Prospective Assessment in the DATATOP Cohort 2001, 10.1212/WNL.56.12.1712.
Perez-Lloret S., Negre-Pages L., Damier P., Delval A., Derkinderen P., Destée A., et al. Prevalence, determinants, and effect on quality of life of freezing of gait in Parkinson disease. JAMA Neurol. 2014, 1-7. 10.1001/jamaneurol.2014.753.
Factor S.A., Scullin M.K., Sollinger A.B., Land J.O., Wood-Siverio C., Zanders L., et al. Freezing of gait subtypes have different cognitive correlates in Parkinson's disease. Park. Relat. Disord. 2014, 20:1359-1364. 10.1016/j.parkreldis.2014.09.023.
Vercruysse S., Devos H., Munks L., Spildooren J., Vandenbossche J., Vandenberghe W., et al. Explaining freezing of gait in Parkinson's disease: motor and cognitive determinants. Mov. Disord. 2012, 27:1644-1651. 10.1002/mds.25183.
Schaafsma J.D., Balash Y., Gurevich T., Bartels A.L., Hausdorff J.M., Giladi N. Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson's disease. Eur. J. Neurol. 2003, 10:391-398. 10.1046/j.1468-1331.2003.00611.x.
Maillet A., Pollak P., Debu B. Imaging gait disorders in parkinsonism: a review. J. Neurol. Neurosurg. Psychiatry 2012, 83:986-993. 10.1136/jnnp-2012-302461.
Vercruysse S., Leunissen I., Vervoort G., Vandenberghe W., Swinnen S., Nieuwboer A. Microstructural changes in white matter associated with freezing of gait in Parkinson's disease. Mov. Disord. 2015, 30:567-576. 10.1002/mds.26130.
Youn J., Lee J.-M., Kwon H., Kim J.S., Son T.O., Cho J.W. Alterations of mean diffusivity of pedunculopontine nucleus pathway in Parkinson's disease patients with freezing of gait. Park. Relat. Disord. 2015, 21:12-17. 10.1016/j.parkreldis.2014.10.003.
Tessitore A., Amboni M., Esposito F., Russo A., Picillo M., Marcuccio L., et al. Resting-state brain connectivity in patients with Parkinson's disease and freezing of gait. Park. Relat. Disord. 2012, 18:781-787. 10.1016/j.parkreldis.2012.03.018.
Fling B.W., Cohen R.G., Mancini M., Carpenter S.D., Fair D.A., Nutt J.G., et al. Functional reorganization of the locomotor network in parkinson patients with freezing of gait. PLoS One 2014, 9. 10.1371/journal.pone.0100291.
Gibb W.R., Lees A.J. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 1988, 51:745-752. 10.1136/jnnp.51.6.745.
Giladi N., Shabtai H., Simon E.S., Biran S., Tal J., Korczyn A.D. Construction of freezing of gait questionnaire for patients with Parkinsonism. Park. Relat. Disord. 2000, 6:165-170. 10.1016/S1353-8020(99)00062-0.
Fazekas F., Chawluk J.B., Alavi A., Hurtig H.I., Zimmerman R.A. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR. Am. J. Roentgenol. 1987, 149:351-356. 10.2214/ajr.149.2.351.
Friston K.J., Penny W.D., Ashburner J., Kiebel S.J., Nichols T.E. Statistical Parametric Mapping: the Analysis of Functional Brain Images 2006.
Tzourio-Mazoyer N., Landeau B., Papathanassiou D., Crivello F., Etard O., Delcroix N., et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 2002, 15:273-289. 10.1006/nimg.2001.0978.
Behzadi Y., Restom K., Liau J., Liu T.T. A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Neuroimage 2007, 37:90-101. 10.1016/j.neuroimage.2007.04.042.
Woodward N.D., Rogers B., Heckers S. Functional resting-state networks are differentially affected in schizophrenia. Schizophr. Res. 2011, 130:86-93. 10.1016/j.schres.2011.03.010.
Eickhoff S.B., Schleicher A., Zilles K., Amunts K. The human parietal operculum. I. Cytoarchitectonic mapping of subdivisions. Cereb. Cortex 2006, 16:254-267. 10.1093/cercor/bhi105.
Ehgoetz Martens K.A., Pieruccini-Faria F., Almeida Q.J. Could sensory mechanisms be a core factor that underlies freezing of gait in Parkinson's disease?. PLoS One 2013, 8. 10.1371/journal.pone.0062602.
Azulay J.P., Mesure S., Blin O. Influence of visual cues on gait in Parkinson's disease: contribution to attention or sensory dependence?. J. Neurol. Sci. 2006, 248:192-195. 10.1016/j.jns.2006.05.008.
Lee S.J., Yoo J.Y., Ryu J.S., Park H.K., Chung S.J. The effects of visual and auditory cues on freezing of gait in patients with Parkinson disease. Am. J. Phys. Med. Rehabil. Assoc. Acad. Physiatr. 2012, 91:2-11. 10.1097/PHM.0b013e31823c7507.
Hausdorff J.M., Lowenthal J., Herman T., Gruendlinger L., Peretz C., Giladi N. Rhythmic auditory stimulation modulates gait variability in Parkinson's disease. Eur. J. Neurosci. 2007, 26:2369-2375. 10.1111/j.1460-9568.2007.05810.x.
Shine J.M., Naismith S.L., Lewis S.J.G. The pathophysiological mechanisms underlying freezing of gait in Parkinson's disease. J. Clin. Neurosci. 2011, 18:1154-1157. 10.1016/j.jocn.2011.02.007.
Shine J.M., Matar E., Ward P.B., Frank M.J., Moustafa A.A., Pearson M., et al. Freezing of gait in Parkinson's disease is associated with functional decoupling between the cognitive control network and the basal ganglia. Brain 2013, 136:3671-3681. 10.1093/brain/awt272.
Mutschler I., Schulze-Bonhage A., Glauche V., Demandt E., Speck O., Ball T. A rapid sound-action association effect in human insular cortex. PLoS One 2007, 2. 10.1371/journal.pone.0000259.
Browner N., Giladi N. What can we learn from freezing of gait in Parkinson's disease?. Curr. Neurol. Neurosci. Rep. 2010, 10:345-351. 10.1007/s11910-010-0127-1.
Stoodley C.J., Valera E.M., Schmahmann J.D. Functional topography of the cerebellum for motor and cognitive tasks: an fMRI study. Neuroimage 2012, 59:1560-1570. 10.1016/j.neuroimage.2011.08.065.
Peterson D.S., Plotnik M., Hausdorff J.M., Earhart G.M. Evidence for a relationship between bilateral coordination during complex gait tasks and freezing of gait in Parkinson's disease. Park. Relat. Disord. 2012, 18:1022-1026. 10.1016/j.parkreldis.2012.05.019.
Plotnik M., Giladi N., Hausdorff J.M. Bilateral coordination of walking and freezing of gait in Parkinson's disease. Eur. J. Neurosci. 2008, 27:1999-2006. 10.1111/j.1460-9568.2008.06167.x.
Mak E., Su L., Williams G.B., O'Brien J.T. Neuroimaging correlates of cognitive impairment and dementia in Parkinson's disease. Park. Relat. Disord. 2015, 20:646-653. 10.1016/j.parkreldis.2015.05.013.
