Essential tremor; Functional connectivity; Resting state; fMRI; Adult; Brain Mapping/methods; Case-Control Studies; Cerebellum/diagnostic imaging; Cerebellum/pathology; Cerebellum/physiopathology; Essential Tremor/diagnostic imaging; Essential Tremor/pathology; Essential Tremor/physiopathology; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging/methods; Male; Middle Aged; Motor Cortex/diagnostic imaging; Motor Cortex/physiopathology; Prospective Studies; Somatosensory Cortex/diagnostic imaging; Somatosensory Cortex/physiopathology; Thalamus/diagnostic imaging; Thalamus/pathology; Thalamus/physiopathology; Brain Mapping; Cerebellum; Magnetic Resonance Imaging; Motor Cortex; Somatosensory Cortex; Thalamus; Radiology, Nuclear Medicine and Imaging; Neurology (clinical); Cardiology and Cardiovascular Medicine
Abstract :
[en] ("[en] INTRODUCTION: Essential tremor (ET) is the most common movement disorder among adults. Although ET has been recognized as a mono-symptomatic benign illness, reports of non-motor symptoms and non-tremor motor symptoms have increased its clinical heterogeneity. The neural correlates of ET are not clearly understood. The aim of this study was to understand the neurobiology of ET using resting state fMRI.
METHODS: Resting state functional MR images of 30 patients with ET and 30 age- and gender-matched healthy controls were obtained. The functional connectivity of the two groups was compared using whole-brain seed-to-voxel-based analysis.
RESULTS: The ET group had decreased connectivity of several cortical regions especially of the primary motor cortex and the primary somatosensory cortex with several right cerebellar lobules compared to the controls. The thalamus on both hemispheres had increased connectivity with multiple posterior cerebellar lobules and vermis. Connectivity of several right cerebellar seeds with the cortical and thalamic seeds had significant correlation with an overall score of Fahn-Tolosa-Marin tremor rating scale (FTM-TRS) as well as the subscores for head tremor and limb tremor.
CONCLUSION: Seed-to-voxel resting state connectivity analysis revealed significant alterations in the cerebello-thalamo-cortical network in patients with ET. These alterations correlated with the overall FTM scores as well as the subscores for limb tremor and head tremor in patients with ET. These results further support the previous evidence of cerebellar pathology in ET.","[en] ","")
Disciplines :
Neurology
Author, co-author :
Lenka, Abhishek; Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India ; Department of Clinical Neurosciences, National Institute of Mental Health & Neurosciences, Bangalore, Karnataka, India
Bhalsing, Ketaki Swapnil; Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India ; Department of Clinical Neurosciences, National Institute of Mental Health & Neurosciences, Bangalore, Karnataka, India
Panda, Rajanikant ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India
Jhunjhunwala, Ketan; Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India ; Department of Clinical Neurosciences, National Institute of Mental Health & Neurosciences, Bangalore, Karnataka, India
Naduthota, Rajini M; Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India
Saini, Jitender; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India
Bharath, Rose Dawn; Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India. drrosedawn@yahoo.com
Yadav, Ravi; Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India
Pal, Pramod Kumar; Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore, 560029, Karnataka, India. pal.pramod@rediffmail.com
Language :
English
Title :
Role of altered cerebello-thalamo-cortical network in the neurobiology of essential tremor.
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