Functional connectivity; Graph theory; Neuroimaging; Primary writing tremor; fMRI; Brain/physiopathology; Brain Mapping/methods; Case-Control Studies; Humans; Magnetic Resonance Imaging/methods; Male; Middle Aged; Neural Pathways/physiopathology; Prospective Studies; Tremor/physiopathology; Writing; Brain; Brain Mapping; Magnetic Resonance Imaging; Neural Pathways; Tremor; Radiology, Nuclear Medicine and Imaging; Neurology (clinical); Cardiology and Cardiovascular Medicine
Abstract :
[en] ("[en] PURPOSE: Primary writing tremor (PWT) is a rare task-specific tremor, which occurs only while writing or while adopting the hand in the writing position. The basic pathophysiology of PWT has not been fully understood. The objective of this study is to explore the alterations in the resting state functional brain connectivity, if any, in patients with PWT using graph theory-based analysis.
METHODS: This prospective case-control study included 10 patients with PWT and 10 age and gender matched healthy controls. All subjects underwent MRI in a 3-Tesla scanner. Several parameters of small-world functional connectivity were compared between patients and healthy controls by using graph theory-based analysis.
RESULTS: There were no significant differences in age, handedness (all right handed), gender distribution (all were males), and MMSE scores between the patients and controls. The mean age at presentation of tremor in the patient group was 51.7 ± 8.6 years, and the mean duration of tremor was 3.5 ± 1.9 years. Graph theory-based analysis revealed that patients with PWT had significantly lower clustering coefficient and higher path length compared to healthy controls suggesting alterations in small-world architecture of the brain. The clustering coefficients were lower in PWT patients in left and right medial cerebellum, right dorsolateral prefrontal cortex (DLPFC), and left posterior parietal cortex (PPC).
CONCLUSION: Patients with PWT have significantly altered small-world brain connectivity in bilateral medial cerebellum, right DLPFC, and left PPC. Further studies with larger sample size are required to confirm our results.","[en] ","")
Disciplines :
Neurology
Author, co-author :
Lenka, Abhishek; Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, 560029, India ; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, Karnataka, 560029, India
Jhunjhunwala, Ketan Ramakant; Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, 560029, India ; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, Karnataka, 560029, India
Panda, Rajanikant ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, 560029, India
Saini, Jitender; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, 560029, India
Bharath, Rose Dawn; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, 560029, India
Yadav, Ravi; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, Karnataka, 560029, India
Pal, Pramod Kumar; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, Karnataka, 560029, India. pal.pramod@rediffmail.com
Language :
English
Title :
Altered brain network measures in patients with primary writing tremor.
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