Writer’s cramp; multi-modal graph theory analysis; repetitive transcranial magnetic stimulation; simultaneous EEG-fMRI; Neuropsychology and Physiological Psychology; Neurology; Psychiatry and Mental Health; Biological Psychiatry; Behavioral Neuroscience
Abstract :
[en] Background and Purpose: Repetitive transcranial magnetic stimulation (rTMS) induces widespread changes in brain connectivity. As the network topology differences induced by a single session of rTMS are less known we undertook this study to ascertain whether the network alterations had a small-world morphology using multi-modal graph theory analysis of simultaneous EEG-fMRI. Method: Simultaneous EEG-fMRI was acquired in duplicate before (R1) and after (R2) a single session of rTMS in 14 patients with Writer's Cramp (WC). Whole brain neuronal and hemodynamic network connectivity were explored using the graph theory measures and clustering coefficient, path length and small-world index were calculated for EEG and resting state fMRI (rsfMRI). Multi-modal graph theory analysis was used to evaluate the correlation of EEG and fMRI clustering coefficients. Result: A single session of rTMS was found to increase the clustering coefficient and small-worldness significantly in both EEG and fMRI (p < 0.05). Multi-modal graph theory analysis revealed significant modulations in the fronto-parietal regions immediately after rTMS. The rsfMRI revealed additional modulations in several deep brain regions including cerebellum, insula and medial frontal lobe. Conclusion: Multi-modal graph theory analysis of simultaneous EEG-fMRI can supplement motor physiology methods in understanding the neurobiology of rTMS in vivo. Coinciding evidence from EEG and rsfMRI reports small-world morphology for the acute phase network hyper-connectivity indicating changes ensuing low-frequency rTMS is probably not "noise".
Disciplines :
Neurology
Author, co-author :
Bharath, Rose D; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India ; Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India
Panda, Rajanikant ; Université de Liège - ULiège > GIGA > GIGA Consciousness - Coma Science Group ; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India ; Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India
Reddam, Venkateswara Reddy; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India ; Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India
Bhaskar, M V; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India
Gohel, Suril; Department of Biomedical Engineering, New Jersey Institute of TechnologyNewark, NJ, United States
Bhardwaj, Sujas; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India ; Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India
Prajapati, Arvind; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India ; Cognitive Neuroscience Centre, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India
Pal, Pramod Kumar; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS)Bangalore, India
Language :
English
Title :
A Single Session of rTMS Enhances Small-Worldness in Writer's Cramp: Evidence from Simultaneous EEG-fMRI Multi-Modal Brain Graph.
Ministry of Science and Technology. Department of Science and Technology
Funding text :
We acknowledge the support of the Department of Science and Technology, Ministry of Science and Technology, (award no. SR/CSI/162/2013) Govt. of India, for providing partial financial support to conduct this study.
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