[en] The Schmidt reaction, the treatment with hydroazoic acid in the presence of a strong acid, converts ketones to amides directly and has been broadly applied in organic synthesis. In this communication, the Schmidt reaction of ketones was carried out in DME solution in a continuous-flow microreactor and gave the amide products. The enclosed small-volume feature of the microreactor made this reaction safe, fast, and cost-effective.
Disciplines :
Chemistry
Author, co-author :
Chen, Yuesu ; Université de Liège - ULiège > Molecular Systems (MolSys) ; Department of Chemistry, Fudan University, Shanghai, China
Liu, Binjie; Department of Chemistry, Fudan University, Shanghai, China
Liu, Xiaofeng; Department of Chemistry, Fudan University, Shanghai, China
Yang, Yongtai; Department of Chemistry, Fudan University, Shanghai, China
Ling, Yun; Department of Chemistry, Fudan University, Shanghai, China
Jia, Yu; Department of Chemistry, Fudan University, Shanghai, China
Language :
English
Title :
Schmidt reaction of ketones in dme solution in a continuous-flow microreactor
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