Beyond being an energy supplier, ATP synthase is a sculptor of mitochondrial cristae.

ATP synthase; F(1)-F(O) ATPase; Lineage-specific subunits; Mitochondrial ATPase; Adenosine Triphosphate; Glycogen Synthase; Mitochondrial Proton-Translocating ATPases; Adenosine Triphosphate/metabolism; Mitochondria/metabolism; Mitochondrial Membranes/metabolism; Glycogen Synthase/metabolism; Mitochondrial Proton-Translocating ATPases/metabolism; F1-FO ATPase; Mitochondria; Mitochondrial Membranes; Biophysics; Biochemistry; Cell Biology

Abstract :

[en] Mitochondrial F1FO-ATP synthase plays a key role in cellular bioenergetics; this enzyme is present in all eukaryotic linages except in amitochondriate organisms. Despite its ancestral origin, traceable to the alpha proteobacterial endosymbiotic event, the actual structural diversity of these complexes, due to large differences in their polypeptide composition, reflects an important evolutionary divergence between eukaryotic lineages. We discuss the effect of these structural differences on the oligomerization of the complex and the shape of mitochondrial cristae.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Miranda-Astudillo, Héctor; Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico

Ostolga-Chavarría, Marcos; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

Cardol, Pierre ; Université de Liège - ULiège > Département des sciences de la vie > Génétique et physiologie des microalgues

González-Halphen, Diego; Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico. Electronic address: dhalphen@ifc.unam.mx

Language :

English

Title :

Beyond being an energy supplier, ATP synthase is a sculptor of mitochondrial cristae.

Publication date :

01 August 2022

Journal title :

Biochimica et Biophysica Acta. Bioenergetics

ISSN :

0005-2728

eISSN :

1879-2650

Publisher :

Elsevier B.V., Netherlands

Volume :

1863

Issue :

Pages :

148569

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S000527282200038X?httpAccept=text/xml

Funding text :

The authors are grateful to Dr. Mauro Degli Esposti (CGG, UNAM) for critically reading the manuscript, and acknowledge the technical expertise of Q.B.P. Miriam Vázquez-Acevedo and Dr. José Luis Santillán Torres (IFC, UNAM) in our ongoing research. H.M.-A.´s research is supported by grant IA204122 ( PAPIIT , DGAPA, UNAM ). P.C. acknowledges financial support from the Belgian Fonds de la Recherche Scientifique FRS- FNRS ( PDR T.0032 ). PC is Senior Research Associate from FNRS. D.G.-H. acknowledges the financial support from grant 21856 (Frontiers of Science, CONACyT , Mexico) and IN209220 (PAPIIT, DGAPA, UNAM ). M. O.-C. is a Ph.D. student at Programa de Maestría y Doctorado en Ciencias Bioquímicas (UNAM) and recipient of a CONACyT fellowship ( 710287 ).

Available on ORBi :

since 12 January 2023

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