[en] ("[en] BACKGROUND: Knee osteoarthritis (OA) is a common condition, associated with a high rate of disability and poor quality of life. Despite the importance of such evidence in public health, no umbrella review (i.e., a review of other systematic reviews and meta-analyses) has systematically assessed evidence on association between knee OA and adverse health outcomes.
AIMS: To map and grade all health outcomes associated with knee OA using an umbrella review approach.
METHODS: The search was made across several databases up to 22 April 2022. We used an umbrella review of systematic reviews with meta-analyses of observational studies assessing the effect sizes, based on random effect summary, 95% prediction intervals, heterogeneity, small study effects, and excess significance bias. The evidence was then graded from convincing (class I) to weak (class IV).
RESULTS: Among 3,847 studies initially considered, five meta-analyses were included for a total of five different outcomes. Three adverse outcomes were significantly associated with knee OA (i.e., cardiovascular mortality, falls, and subclinical atherosclerosis). The presence of knee OA was associated with a significantly higher risk of cardiovascular mortality (odds ratio, OR = 1.17; 95%CI, confidence intervals: 1.02-1.34), falls (RR = 1.34; 95%CI: 1.10-1.64), and conditions associated with subclinical atherosclerosis (OR = 1.43; 95%CI: 1.003-2.05). The certainty of each of this evidence was weak.
CONCLUSIONS: Our umbrella review suggests that knee OA can be considered as putative risk factor for some medical conditions, including cardiovascular diseases and falls, however, it is important to note that the evidence is affected by potential biases.","[en] ","")
Disciplines :
Public health, health care sciences & services
Author, co-author :
Veronese, Nicola ; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro, 141, 90127, Palermo, Italy. nicola.veronese@unipa.it ; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia. nicola.veronese@unipa.it
Honvo, Germain ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Bruyère, Olivier ; Université de Liège - ULiège > Unité de recherche Santé publique, épidémiologie et économie de la santé (URSAPES)
Rizzoli, René ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland
Barbagallo, Mario; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro, 141, 90127, Palermo, Italy
Maggi, Stefania; CNR-Neuroscience Institute, Aging Branch, Padua, Italy
Smith, Lee; Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK
Sabico, Shaun; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
Al-Daghri, Nasser ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia
Cooper, Cyrus ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé ; MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, UK
Pegreffi, Francesco; Department for Life Quality Studies, University of Bologna, Bologna, Italy
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique
Language :
English
Title :
Knee osteoarthritis and adverse health outcomes: an umbrella review of meta-analyses of observational studies.
Publication date :
2023
Journal title :
Aging Clinical and Experimental Research
ISSN :
1594-0667
eISSN :
1720-8319
Publisher :
Springer Science and Business Media Deutschland GmbH, Germany
KSU - King Saud University UniPa - Università degli Studi di Palermo
Funding text :
Open access funding provided by Università degli Studi di Palermo within the CRUI-CARE Agreement. The authors extend their appreciation to the Deanship of Scientific Research, King Saud University for funding through Vice Deanship of Scientific Research Chairs.
Murray CJ, Vos T, Lozano R et al (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2197–2223 DOI: 10.1016/S0140-6736(12)61689-4
Woolf AD, Pfleger B (2003) Burden of major musculoskeletal conditions. Bull World Health Organ 81:646–656
Vos T, Flaxman AD, Naghavi M et al (2012) Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2163–2196 DOI: 10.1016/S0140-6736(12)61729-2
Cross M, Smith E, Hoy D et al (2014) The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis 73:1323–1330 DOI: 10.1136/annrheumdis-2013-204763
Clynes MA, Jameson KA, Edwards MH et al (2019) Impact of osteoarthritis on activities of daily living: does joint site matter? Aging Clin Exp Res 31:1049–1056 DOI: 10.1007/s40520-019-01163-0
Salaffi F, Di Carlo M, Carotti M et al (2021) Frailty prevalence according to the Survey of Health, Ageing and Retirement in Europe-Frailty Instrument (SHARE-FI) definition, and its variables associated, in patients with symptomatic knee osteoarthritis: findings from a cross-sectional study. Aging Clin Exp Res 33:1519–1527 DOI: 10.1007/s40520-020-01667-0
Jeon H, Lee S-U, Lim J-Y et al (2019) Low skeletal muscle mass and radiographic osteoarthritis in knee, hip, and lumbar spine: A cross-sectional study. Aging Clin Exp Res 31:1557–1562 DOI: 10.1007/s40520-018-1108-5
Xie H, Ma Y, Shao M et al (2021) Telomere length in patients with osteoarthritis: a systematic review and meta-analysis. Aging Clin Exp Res 34:495–503 DOI: 10.1007/s40520-021-01944-6
Hall AJ, Stubbs B, Mamas MA et al (2016) Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis. Eur J Prev Cardiol 23:938–946 DOI: 10.1177/2047487315610663
Veronese N, Cooper C, Reginster J-Y, Hochberg M, Branco J, Bruyère O, Chapurlat R, Al-Daghri N, Dennison E, Herrero-Beaumont G (2019) Type 2 diabetes mellitus and osteoarthritis. Seminars in arthritis and rheumatism. Elsevier, pp 9–19
Yasuda E, Nakamura R, Matsugi R et al (2018) Association between the severity of symptomatic knee osteoarthritis and cumulative metabolic factors. Aging Clin Exp Res 30:481–488 DOI: 10.1007/s40520-017-0808-6
Hochberg M (2008) Mortality in osteoarthritis. Clin Exp Rheumatol 26:S120
Aromataris E, Fernandez R, Godfrey CM et al (2015) Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach. JBI Evid Implement 13:132–140
Higgins J, Thomas J, Chandler J et al (eds) (2019) Cochrane Handbook for Systematic Reviews of Interventions. John Wiley & Sons, Chichester (UK)
Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev 10:1–11 DOI: 10.1186/s13643-021-01626-4
Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E (2017) AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. bmj 358:
Geisser S (1974) A predictive approach to the random effect model. Biometrika 61:101–107 DOI: 10.1093/biomet/61.1.101
Nagashima K, Noma H, Furukawa TA (2019) Prediction intervals for random-effects meta-analysis: a confidence distribution approach. Stat Methods Med Res 28:1689–1702 DOI: 10.1177/0962280218773520
Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558 DOI: 10.1002/sim.1186
Zhang Z, Xu X, Ni H (2013) Small studies may overestimate the effect sizes in critical care meta-analyses: a meta-epidemiological study. Crit Care 17:1–9 DOI: 10.1186/cc11919
Harbord RM, Harris RJ, Sterne JA (2009) Updated tests for small-study effects in meta-analyses. Stand Genomic Sci 9:197–210
Ioannidis JP, Trikalinos TA (2007) An exploratory test for an excess of significant findings. Clin Trials 4:245–253 DOI: 10.1177/1740774507079441
Papatheodorou SI, Tsilidis KK, Evangelou E et al (2015) Application of credibility ceilings probes the robustness of meta-analyses of biomarkers and cancer risk. J Clin Epidemiol 68:163–174 DOI: 10.1016/j.jclinepi.2014.09.004
Veronese N, Cereda E, Maggi S, et al. (2016) Osteoarthritis and mortality: A prospective cohort study and systematic review with meta-analysis. Semin Arthritis Rheum 46:160–167
Wang H, Bai J, He B et al (2016) Osteoarthritis and the risk of cardiovascular disease: a meta-analysis of observational studies. Sci Rep 6:39672 DOI: 10.1038/srep39672
Deng ZH, Xu J, Long LJ et al (2021) Association between hip and knee osteoarthritis with falls: A systematic review and meta-analysis. Int J Clin Pract 75:e14537 DOI: 10.1111/ijcp.14537
Leyland KM, Gates LS, Sanchez-Santos MT et al (2021) Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data. Aging Clin Exp Res 33:529–545 DOI: 10.1007/s40520-020-01762-2
Macedo MB, Santos V, Pereira RMR et al (2022) Association between osteoarthritis and atherosclerosis: A systematic review and meta-analysis. Exp Gerontol 161:111734 DOI: 10.1016/j.exger.2022.111734
Stürmer T, Sun Y, Sauerland S et al (1998) Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study. J Rheumatol 25:1827–1832
Veronese N, Stubbs B, Solmi M et al (2018) Knee osteoarthritis and risk of hypertension: a longitudinal cohort study. Rejuvenation Res 21:15–21 DOI: 10.1089/rej.2017.1917
Karasik D, Kiel D, Kiely D et al (2006) Abdominal aortic calcification and exostoses at the hand and lumbar spine: the Framingham Study. Calcif Tissue Int 78:1–8 DOI: 10.1007/s00223-005-0054-3
Kurunlahti M, Tervonen O, Vanharanta H et al (1999) Association of atherosclerosis with low back pain and the degree of disc degeneration. Spine 24:2080 DOI: 10.1097/00007632-199910150-00003
Li X, Zhou Y, Liu J (2022) Association Between Prediabetes and Osteoarthritis: A Meta-Analysis. Horm Metab Res 54:104–112 DOI: 10.1055/a-1730-5251
Veronese N, Cooper C, Reginster JY et al (2019) Type 2 diabetes mellitus and osteoarthritis. Semin Arthritis Rheum 49:9–19 DOI: 10.1016/j.semarthrit.2019.01.005
Yoshimura N, Muraki S, Oka H et al (2012) Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. Osteoarthritis Cartilage 20:1217–1226 DOI: 10.1016/j.joca.2012.06.006
Wen C, Chen Y, Tang H et al (2013) Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus. Osteoarthritis Cartilage 21:1716–1723 DOI: 10.1016/j.joca.2013.06.027
Veronese N, Trevisan C, De Rui M et al (2016) Association of Osteoarthritis with Increased Risk of cardiovascular diseases in the elderly: findings from the Progetto Veneto Anziano study cohort. Arthritis Rheumatol 68:1136–1144
Davis A, Robson J (2016) The dangers of NSAIDs: look both ways. Br J Gen Pract 66:172–173 DOI: 10.3399/bjgp16X684433
Gay A, Towler DA (2017) Wnt signaling in cardiovascular disease: opportunities and challenges. Curr Opin Lipidol 28:387 DOI: 10.1097/MOL.0000000000000445
Fan D, Takawale A, Lee J et al (2012) Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease. Fibrogenesis Tissue Repair 5:1–13 DOI: 10.1186/1755-1536-5-15
Hsieh R-L, Lee W-C, Lo M-T et al (2013) Postural stability in patients with knee osteoarthritis: comparison with controls and evaluation of relationships between postural stability scores and international classification of functioning, disability and health components. Arch Phys Med Rehabil 94:e341 DOI: 10.1016/j.apmr.2012.09.022
Ren X, Lutter C, Kebbach M, Bruhn S, Yang Q, Bader R, Tischer T (2022) Compensatory responses during slip-induced perturbation in patients with knee osteoarthritis compared with healthy older adults: an increased risk of falls? Frontiers in bioengineering and biotechnology 10:
Doré AL, Golightly YM, Mercer VS et al (2015) Lower-extremity osteoarthritis and the risk of falls in a community-based longitudinal study of adults with and without osteoarthritis. Arthritis Care Res 67:633–639 DOI: 10.1002/acr.22499
