The role of the Major Histocompatibility Complex in bovine embryo transfer

[en] An intact maternal immune system is not essential for successful reproduction but there is good evidence indicating that it plays an important role during pregnancy. The most prominent candidates for maternal immune recognition are the Major Histocompatibility Complex (MHC) antigens. We have investigated the role of embryo-recipient MHC-compatibility in vivo by studying pregnancies after transfer of embryos into 100% compatible or 100% incompatible heifers. Our results showed that MHC antigens are selectively recognized by the immune system of the recipient and suggest that they can influence the outcome of pregnancy. If these results can be confirmed in larger scale studies, new strategies to improve ET pregnancy rates could be applied.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Aguilar, B.

Vos, P.L.A.M.

Beckers, Jean-François ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > Physiologie de la reproduction

Hensen, E.J.

Dieleman, S.J.; Dept of Herd Health, Faculty of Veterinary Medicine, 3584 CL Utrecht, Netherlands

Language :

English

Title :

The role of the Major Histocompatibility Complex in bovine embryo transfer

Publication date :

1997

Event name :

IETS

Event date :

January 1997

Audience :

International

Journal title :

Theriogenology

ISSN :

0093-691X

eISSN :

1879-3231

Publisher :

Elsevier BV

Volume :

Issue :

Pages :

111 - 120

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://api.elsevier.com/content/article/PII:S0093691X96003457?httpAccept=text/xml

Funding text :

Acknowledgments: The work of B. Aguilar was supported by a fellowship of the Spanish Ministry of Science and Education (FP93-17155554) and by Holland Genetics (Arnhem, The Netherlands). aReprint requests: S.J. Dieleman. Dept of Herd Health and Reproduction, Faculty of Veterinary Medicine, Yalelaan 7, 3584 CL Utrecht (The Netherlands). E-mail: dieleman@bdv.dgk.ruu.nl.

Available on ORBi :

since 10 January 2023

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Bibliography

Antczak DF. Maternal antibody responses in pregnancy. Curr Op Immunol 1989; 1: 1135-1140.
Arcellana-Panlilio MY and Schultz GA. Temporal and spatial expression of major histocompatibility complex class I H-2K in the early mouse embryo. Biol Reprod 1994; 51: 169-183.
Claas FH, Gijbels Y, Van der Velden-de Munck J and Van Rood JJ. Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life. Science 1988; 241: 1815-1817.
Croy BA and Chapeau C. Evaluation of the pregnancy immunotrophism hypothesis by assessment of the reproductive performance of young adult mice of genotype scid/scid.bg/bg. J Reprod Fertil 1990; 88: 231-239.
Dieleman SJ and Bevers MM. Effects of monoclonal antibody against PMSG administered shortly after the preovulatory LH surge on time and number of ovulations in PMSG/PG-treated cows. J Reprod Fertil 1987; 533-542.
Drezen JM, Barra J, Babinet C and Morello D. MHC class I genes are not imprinted in the mouse placenta. Immunogenetics 1994; 40: 255-259.
Ellis SA and McMichael AJ. Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA class I molecule. J Immunol 1990; 144: 731-739.
Fernandez N, Sprinks MT, Cooper JC, Dealtry GB, Sellens MH, Reyes-Engel A and Kurpisz M. Embryonic development and the major histocompatibility complex. In: Kurpisz M and Fernandez N (ed), Immunology of human reproduction. Oxford: BIOS scientific publishers Ltd. 1995; 185-198.
Hensen EJ, Kristensen B. Wever P, Grosveld Stulemeyer MC and Tielen MJM. Histocompatibility and swine litter size. Proceedings of the XXIV International Conference on Animal Genetics, Prague 1994; 54 (abstr).
Hines HC and Newman MJ. Production of foetally stimulated lymphocytotoxic antibodies by multiparous cows. Anim Blood Groups Biochem Genet 1981; 12: 201-206.
Ishitani A and Geraghty DE. Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens. Proc Nat Acad Sci USA 1992; 89: 3947-3951.
Jaffe L, Robertson EJ and Bikoff EKJ. Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens. Proc Nat Acad Sci USA 1992; 89: 5927-5931.
Janeway CA and Travers P. Immunogenetics: the major histocompatibility complex. In: The immune system in health and disease. London: Current Biology Ltd. 1996, 2:22-2:27.
Joosten I, Sanders MF and Hensen EJ. Involvement of major histocompatibility complex class 1 compatibility between dam and calf in the aetiology of bovine retained placenta. Anim Genet 1991; 22: 455-463.
Klein J. In: Natural history of the major histocompatibility complex. New York: John Wiley & Sons. 1986.
Kurpisz M, Fernandez N and Fiszer D. The expression of MHC genes in reproductive organs and their role in reproduction. In: Kurpisz M and Fernandez N (ed), Immunology of human reproduction. Oxford: BIOS scientific publishers Ltd. 1995; 163-185.
Lala PK, Parkar RS, Kearns M, Johnson S and Scodras JM. Immunological aspects of the decidual response. In: Clark DA and Croy BA (ed), Reproductive Immunology. New York: Elsevier science publishers. 1986; 190-198.
Low BG, Hansen PJ, Drost M and Gogolin-Ewens KJ. Expression of major histocompatibility complex antigens on the bovine placenta. J Reprod Fertil 1990; 90: 235-243.
Matousek J and Riha J. Anti-leukocyte antibodies and embryonic mortality in embryo transferred cows. Anim Genet 1991; 22: 245-250.
Medawar PB. Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates. Symp Soc Exp Biol 1953; 7: 320-338.
Mueller UW, Hawes CS, Wright AE, Petropoulos A, Deboni E, Firgaira FA, Morley AA, Turner DR and Jones WR. Isolation of fetal trophoblast cells from peripheral blood of pregnant women. Lancet 1990; 336: 197-200.
Nelson JL, Hughes KA, Smith AG, Nisperos BB, Branchaud AM and Hansen JA. Maternal-fetal disparity in HLA class II alloantigens and the pregnancy induced amelioration of rheumatoid arthritis. New Eng J Med 1993; 329: 466-471.
Newman MJ and Hines HC. Stimulation of maternal anti-lymphocyte antibodies by first gestation bovine fetuses. J Reprod Fertil 1980; 60: 237-241.
Ober C, Steck T, van der Ven K, Billstrand C, Messer L, Kwak J, Beaman K and Beer A. MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion. J Reprod Immunol 1993; 25: 195-207.
Reed E, Beer AE, Hutcherson H, King DW and Suciu-Foca N. The alloantibody response of pregnant women and its suppression by soluble HLA antigens and anti-idiotypic antibodies. J Reprod Immunol 1991; 20: 115-128.
Sanders SK, Giblin PA and Kavaths P. Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class I molecule on cytotrophoblasts. J Exp Med 1991; 174: 737-740.
Schmidt CM and Orr HT. Maternal/fetal interactions: the role of the MHC class I molecule HLA-G. Crit Rev Immunol 1993; 13: 207-224.
Sprinks MT, Sellens MH, Dealtry GB and Fernandez N. Preimplantation mouse embryos express MHC class I genes before the first cleavage division. Immunogenetics 1993; 38:35-40
Suzuki T, Hiromatsu K, Ando Y, Okamoto T, Tomoda Y and Yoshikai Y. Regulatory role of gd T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response. J Immunol 1995; 154: 4476-4484.
Tafuri A, Alferink J, Möller P, Hämmerling GJ and Arnold B. T cell awareness of paternal alloantigens during pregnancy. Science 1995; 270: 630-633.
Templeton JW, Tipton RC, Garber T, Bondioli K and Kraemer DC. Expression and genetic segregation of parental BoLA serotypes in bovine embryos. Anim Genet 1987; 18: 317-322.
Verp MS, Sibul M, Billstrand C, Belen G, Hsu M and Ober C. Maternal-fetal histocompatibility in intrauterine growth retarded and normal weight babies. Am J Reprod Immunol 1993; 29: 195-198.
Voisin GA and Raghupathy R. Immunodeviation of the immune response during pregnancy. In: Kurpisz M and Fernandez N (ed), Immunology of human reproduction. Oxford: BIOS scientific publishers Ltd. 1995; 335-355.
Wegmann TG. Maternal T cells promote placental growth and prevent spontaneous abortion. Immunol Letters 1988; 17: 297-302.
Yamashita T, Fujii T, Watanabe Y, Tokunaga K, Tadokoro K, Juji T and Taketani Ya. HLA-G gene polymorphism in a Japanase population. Immunogenetics 1996; 44: 186-191.
Zavy MT. Embryonic mortality in cattle. In: Zavy MT and Geisert RD (ed), Embryonic mortality in domestic species. Boca Raton: CRC Press Inc. 1994; 99-141.
Zhou M, Horuzsko A, Tarazona R and Mellor A. Effects of paternally inherited MHC class I antigens on maternal T cells during pregnancy. Proceedings of the Keystone Conference 1996; 4149 (abstr).
Zinkernagel RP and Doherty PC. MHC restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction specifity. Adv Immunol 1979; 27: 51-177.
Zoli AP, Guilbault LA, Delahaut P, Benítez Ortíz W and Beckers JF. Radioimmunoassay of a bovine pregnancy-associated glycoprotein in serum: its application for pregnancy diagnosis. Biol Reprod 1992; 83-92.